Contribution of MUTYH Variants to Male Breast Cancer Risk: Results From a Multicenter Study in Italy

Contribution of MUTYH Variants to Male Breast Cancer Risk: Results From a Multicenter Study in Italy

Inherited mutations in BRCA1, and, mainly, BRCA2 genes are associated with increased risk of male breast cancer (MBC). Mutations in PALB2 and CHEK2 genes may also increase MBC risk. Overall, these genes are functionally linked to DNA repair pathways, highlighting the central role of genome maintenan...

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Main Authors: Piera Rizzolo, Valentina Silvestri, Agostino Bucalo, Veronica Zelli, Virginia Valentini, Irene Catucci, Ines Zanna, Giovanna Masala, Simonetta Bianchi, Alessandro Mauro Spinelli, Stefania Tommasi, Maria Grazia Tibiletti, Antonio Russo, Liliana Varesco, Anna Coppa, Daniele Calistri, Laura Cortesi, Alessandra Viel, Bernardo Bonanni, Jacopo Azzollini, Siranoush Manoukian, Marco Montagna, Paolo Radice, Domenico Palli, Paolo Peterlongo, Laura Ottini
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Oncology
Subjects:
male breast cancer
genetic susceptibility
BRCA1/2
MUTYH
NGS
MUTYH-associated polyposis (MAP) syndrome
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00583/full

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