Persistent symptoms of severe and critical COVID-19: A cross-sectional study after more than 120 days from disease onset
Objective: The objective of this study is to assess the prevalence and predictors of symptom persistence associated with severe and critical coronavirus disease-2019 (COVID-19) after more than 120 days from the onset of the disease. Materials and Methods: This is a single-center, cross-sectional stu...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-01-01
|
| Series: | Journal of Nature and Science of Medicine |
| Subjects: | |
| Online Access: | http://www.jnsmonline.org/article.asp?issn=2589-627X;year=2023;volume=6;issue=2;spage=84;epage=88;aulast=Alraddadi |
| _version_ | 1827896568704925696 |
|---|---|
| author | Mohammed A Alraddadi Hamad A Alyami Nasser T Alqahtani Noha K Khalil Asmaa A Alraddadi Naif H Alotaibi |
| author_facet | Mohammed A Alraddadi Hamad A Alyami Nasser T Alqahtani Noha K Khalil Asmaa A Alraddadi Naif H Alotaibi |
| author_sort | Mohammed A Alraddadi |
| collection | DOAJ |
| description | Objective: The objective of this study is to assess the prevalence and predictors of symptom persistence associated with severe and critical coronavirus disease-2019 (COVID-19) after more than 120 days from the onset of the disease. Materials and Methods: This is a single-center, cross-sectional study of 125 adults who were admitted to King Khalid University Hospital (Riyadh, Saudi Arabia) with severe and critical COVID-19 between March 4 and December 1, 2020. Telephone interviews were conducted between April 1 and May 31, 2021, to collect data on COVID-19 symptoms persisting after more than 120 days from the onset of the disease. All of the participants had been discharged from the hospital and had resumed their normal lives. Symptoms of COVID-19 that had not been present before the onset of the disease were considered to be persistent if participants confirmed their continued presence at the time of the interview. The impact of chronic disease on persistent symptoms was considered. Results: About 42.4% (53/125) of patients had at least one or more persistent symptoms; 27.2% (34/125) had breathlessness, 5.6% (7/125) cough, and 4.8% (6/125) chest pain. These three symptoms had been present from the first presentation. Hair loss was reported by 14.4% (18/125), forgetfulness by 8% (10/125), difficulty in concentrating by 6.4% (8/125), and lack of energy by 4% (5/125). Those had manifested after more than 120 days from the symptom's onset. The major factors in suffering from persistent symptoms were intensive care unit (ICU) admission or/and fever (temperature >38°), or/and diarrhea. There was no correlation between persistent symptoms and chronic diseases. Conclusions: After more than 120 days from the confirmation of severe and critical COVID-19, more than one-third of discharged adults were found to have one or more persistent symptoms. These were mainly associated with the need for ICU admission, fever (temperature >38°), and diarrhea. More care needs to be given to COVID-19 patients in the presence of these factors and prolonged medical care would appear to be essential. |
| first_indexed | 2024-03-12T22:36:57Z |
| format | Article |
| id | doaj.art-edab47b89251405aa7a8c9863cf7b791 |
| institution | Directory Open Access Journal |
| issn | 2589-627X 2589-6288 |
| language | English |
| last_indexed | 2024-03-12T22:36:57Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Nature and Science of Medicine |
| spelling | doaj.art-edab47b89251405aa7a8c9863cf7b7912023-07-21T11:57:02ZengWolters Kluwer Medknow PublicationsJournal of Nature and Science of Medicine2589-627X2589-62882023-01-0162848810.4103/jnsm.jnsm_139_21Persistent symptoms of severe and critical COVID-19: A cross-sectional study after more than 120 days from disease onsetMohammed A AlraddadiHamad A AlyamiNasser T AlqahtaniNoha K KhalilAsmaa A AlraddadiNaif H AlotaibiObjective: The objective of this study is to assess the prevalence and predictors of symptom persistence associated with severe and critical coronavirus disease-2019 (COVID-19) after more than 120 days from the onset of the disease. Materials and Methods: This is a single-center, cross-sectional study of 125 adults who were admitted to King Khalid University Hospital (Riyadh, Saudi Arabia) with severe and critical COVID-19 between March 4 and December 1, 2020. Telephone interviews were conducted between April 1 and May 31, 2021, to collect data on COVID-19 symptoms persisting after more than 120 days from the onset of the disease. All of the participants had been discharged from the hospital and had resumed their normal lives. Symptoms of COVID-19 that had not been present before the onset of the disease were considered to be persistent if participants confirmed their continued presence at the time of the interview. The impact of chronic disease on persistent symptoms was considered. Results: About 42.4% (53/125) of patients had at least one or more persistent symptoms; 27.2% (34/125) had breathlessness, 5.6% (7/125) cough, and 4.8% (6/125) chest pain. These three symptoms had been present from the first presentation. Hair loss was reported by 14.4% (18/125), forgetfulness by 8% (10/125), difficulty in concentrating by 6.4% (8/125), and lack of energy by 4% (5/125). Those had manifested after more than 120 days from the symptom's onset. The major factors in suffering from persistent symptoms were intensive care unit (ICU) admission or/and fever (temperature >38°), or/and diarrhea. There was no correlation between persistent symptoms and chronic diseases. Conclusions: After more than 120 days from the confirmation of severe and critical COVID-19, more than one-third of discharged adults were found to have one or more persistent symptoms. These were mainly associated with the need for ICU admission, fever (temperature >38°), and diarrhea. More care needs to be given to COVID-19 patients in the presence of these factors and prolonged medical care would appear to be essential.http://www.jnsmonline.org/article.asp?issn=2589-627X;year=2023;volume=6;issue=2;spage=84;epage=88;aulast=Alraddadicoronavirus disease-2019persistent symptomssevere and critical coronavirus disease-2019 |
| spellingShingle | Mohammed A Alraddadi Hamad A Alyami Nasser T Alqahtani Noha K Khalil Asmaa A Alraddadi Naif H Alotaibi Persistent symptoms of severe and critical COVID-19: A cross-sectional study after more than 120 days from disease onset Journal of Nature and Science of Medicine coronavirus disease-2019 persistent symptoms severe and critical coronavirus disease-2019 |
| title | Persistent symptoms of severe and critical COVID-19: A cross-sectional study after more than 120 days from disease onset |
| title_full | Persistent symptoms of severe and critical COVID-19: A cross-sectional study after more than 120 days from disease onset |
| title_fullStr | Persistent symptoms of severe and critical COVID-19: A cross-sectional study after more than 120 days from disease onset |
| title_full_unstemmed | Persistent symptoms of severe and critical COVID-19: A cross-sectional study after more than 120 days from disease onset |
| title_short | Persistent symptoms of severe and critical COVID-19: A cross-sectional study after more than 120 days from disease onset |
| title_sort | persistent symptoms of severe and critical covid 19 a cross sectional study after more than 120 days from disease onset |
| topic | coronavirus disease-2019 persistent symptoms severe and critical coronavirus disease-2019 |
| url | http://www.jnsmonline.org/article.asp?issn=2589-627X;year=2023;volume=6;issue=2;spage=84;epage=88;aulast=Alraddadi |
| work_keys_str_mv | AT mohammedaalraddadi persistentsymptomsofsevereandcriticalcovid19acrosssectionalstudyaftermorethan120daysfromdiseaseonset AT hamadaalyami persistentsymptomsofsevereandcriticalcovid19acrosssectionalstudyaftermorethan120daysfromdiseaseonset AT nassertalqahtani persistentsymptomsofsevereandcriticalcovid19acrosssectionalstudyaftermorethan120daysfromdiseaseonset AT nohakkhalil persistentsymptomsofsevereandcriticalcovid19acrosssectionalstudyaftermorethan120daysfromdiseaseonset AT asmaaaalraddadi persistentsymptomsofsevereandcriticalcovid19acrosssectionalstudyaftermorethan120daysfromdiseaseonset AT naifhalotaibi persistentsymptomsofsevereandcriticalcovid19acrosssectionalstudyaftermorethan120daysfromdiseaseonset |