Global longitudinal strain in chronic asymptomatic aortic regurgitation: systematic review
Chronic aortic regurgitation (AR) patients typically remain asymptomatic for a long time. Left ventricular mechanics, namely global longitudinal strain (GLS), has been associated with outcomes in AR patients. The authors conducted a systematic review to summarize and appraise GLS impact on mortality...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-10-01
|
| Series: | Echo Research and Practice |
| Subjects: | |
| Online Access: | https://erp.bioscientifica.com/view/journals/echo/7/3/ERP-20-0024.xml |
| _version_ | 1817987590407585792 |
|---|---|
| author | Diana deCampos Rogério Teixeira Carolina Saleiro Ana Botelho Lino Gonçalves |
| author_facet | Diana deCampos Rogério Teixeira Carolina Saleiro Ana Botelho Lino Gonçalves |
| author_sort | Diana deCampos |
| collection | DOAJ |
| description | Chronic aortic regurgitation (AR) patients typically remain asymptomatic for a long time. Left ventricular mechanics, namely global longitudinal strain (GLS), has been associated with outcomes in AR patients. The authors conducted a systematic review to summarize and appraise GLS impact on mortality, the need for aortic valve replacement (AVR) and disease progression in AR patients. A literature search was performed using these key terms ‘aortic regurgitation’ and ‘longitudinal strain’ looking at all randomized and nonrandomized studies conducted on chronic aortic regurgitation. The search yielded six observational studies published from 2011 and 2018 with a total of 1571 patients with moderate to severe chronic AR. Only two studies included all-cause mortality as their endpoint. The other studies looked at the association between GLS with AVR and disease progression. The mean follow-up period was 4.2 years. We noted a great variability of clinical, methodological and/or statistical origin. Thus, meta-analytic portion of our study was limited. Despite a relevant heterogeneity, an impaired GLS was associated with adverse cardiac outcomes. Left ventricular GLS may offer incremental value in risk stratification and decision-making. |
| first_indexed | 2024-04-14T00:23:16Z |
| format | Article |
| id | doaj.art-edad5c39a8164cbeb59e126104333fba |
| institution | Directory Open Access Journal |
| issn | 2055-0464 2055-0464 |
| language | English |
| last_indexed | 2024-04-14T00:23:16Z |
| publishDate | 2020-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Echo Research and Practice |
| spelling | doaj.art-edad5c39a8164cbeb59e126104333fba2022-12-22T02:22:53ZengBMCEcho Research and Practice2055-04642055-04642020-10-01733948https://doi.org/10.1530/ERP-20-0024Global longitudinal strain in chronic asymptomatic aortic regurgitation: systematic reviewDiana deCampos0Rogério Teixeira1Carolina Saleiro2Ana Botelho3Lino Gonçalves4Serviço de Cardiologia, Centro Hospitalar e Universitário de Coimbra, Coimbra, PortugalServiço de Cardiologia, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal; Faculdade de Medicina, Universidade de Coimbra, Coimbra, PortugalServiço de Cardiologia, Centro Hospitalar e Universitário de Coimbra, Coimbra, PortugalServiço de Cardiologia, Centro Hospitalar e Universitário de Coimbra, Coimbra, PortugalServiço de Cardiologia, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal; Faculdade de Medicina, Universidade de Coimbra, Coimbra, PortugalChronic aortic regurgitation (AR) patients typically remain asymptomatic for a long time. Left ventricular mechanics, namely global longitudinal strain (GLS), has been associated with outcomes in AR patients. The authors conducted a systematic review to summarize and appraise GLS impact on mortality, the need for aortic valve replacement (AVR) and disease progression in AR patients. A literature search was performed using these key terms ‘aortic regurgitation’ and ‘longitudinal strain’ looking at all randomized and nonrandomized studies conducted on chronic aortic regurgitation. The search yielded six observational studies published from 2011 and 2018 with a total of 1571 patients with moderate to severe chronic AR. Only two studies included all-cause mortality as their endpoint. The other studies looked at the association between GLS with AVR and disease progression. The mean follow-up period was 4.2 years. We noted a great variability of clinical, methodological and/or statistical origin. Thus, meta-analytic portion of our study was limited. Despite a relevant heterogeneity, an impaired GLS was associated with adverse cardiac outcomes. Left ventricular GLS may offer incremental value in risk stratification and decision-making.https://erp.bioscientifica.com/view/journals/echo/7/3/ERP-20-0024.xmlaortic regurgitationglobal longitudinal strainoutcomesaortic valve replacement |
| spellingShingle | Diana deCampos Rogério Teixeira Carolina Saleiro Ana Botelho Lino Gonçalves Global longitudinal strain in chronic asymptomatic aortic regurgitation: systematic review Echo Research and Practice aortic regurgitation global longitudinal strain outcomes aortic valve replacement |
| title | Global longitudinal strain in chronic asymptomatic aortic regurgitation: systematic review |
| title_full | Global longitudinal strain in chronic asymptomatic aortic regurgitation: systematic review |
| title_fullStr | Global longitudinal strain in chronic asymptomatic aortic regurgitation: systematic review |
| title_full_unstemmed | Global longitudinal strain in chronic asymptomatic aortic regurgitation: systematic review |
| title_short | Global longitudinal strain in chronic asymptomatic aortic regurgitation: systematic review |
| title_sort | global longitudinal strain in chronic asymptomatic aortic regurgitation systematic review |
| topic | aortic regurgitation global longitudinal strain outcomes aortic valve replacement |
| url | https://erp.bioscientifica.com/view/journals/echo/7/3/ERP-20-0024.xml |
| work_keys_str_mv | AT dianadecampos globallongitudinalstraininchronicasymptomaticaorticregurgitationsystematicreview AT rogerioteixeira globallongitudinalstraininchronicasymptomaticaorticregurgitationsystematicreview AT carolinasaleiro globallongitudinalstraininchronicasymptomaticaorticregurgitationsystematicreview AT anabotelho globallongitudinalstraininchronicasymptomaticaorticregurgitationsystematicreview AT linogoncalves globallongitudinalstraininchronicasymptomaticaorticregurgitationsystematicreview |