Determinants of Endogenous Fibrinolysis in Whole Blood Under High Shear in Patients With Myocardial Infarction
Summary: Hypofibrinolysis is a recently-recognized risk factor for recurrent cardiovascular events in patients with ST-segment elevation myocardial infarction (STEMI), but the mechanistic determinants of this are not well understood. In patients with STEMI, we show that the effectiveness of endogeno...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | JACC: Basic to Translational Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452302X22002145 |
| _version_ | 1798018909983473664 |
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| author | Rahim Kanji, MB, BS Ying X. Gue, MB, BS, PhD Mohamed F. Farag, MB, BS, PhD Neil H. Spencer, PhD Nicola J. Mutch, BSc, PhD Diana A. Gorog, MD, PhD |
| author_facet | Rahim Kanji, MB, BS Ying X. Gue, MB, BS, PhD Mohamed F. Farag, MB, BS, PhD Neil H. Spencer, PhD Nicola J. Mutch, BSc, PhD Diana A. Gorog, MD, PhD |
| author_sort | Rahim Kanji, MB, BS |
| collection | DOAJ |
| description | Summary: Hypofibrinolysis is a recently-recognized risk factor for recurrent cardiovascular events in patients with ST-segment elevation myocardial infarction (STEMI), but the mechanistic determinants of this are not well understood. In patients with STEMI, we show that the effectiveness of endogenous fibrinolysis in whole blood is determined in part by fibrinogen level, high sensitivity C-reactive protein, and shear-induced platelet reactivity, the latter directly related to the speed of thrombin generation. Our findings strengthen the evidence for the role of cellular components and bidirectional crosstalk between coagulatory and inflammatory pathways as determinants of hypofibrinolysis. |
| first_indexed | 2024-04-11T16:32:04Z |
| format | Article |
| id | doaj.art-edae2ac951dd4dfab5ab97d565a49629 |
| institution | Directory Open Access Journal |
| issn | 2452-302X |
| language | English |
| last_indexed | 2024-04-11T16:32:04Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JACC: Basic to Translational Science |
| spelling | doaj.art-edae2ac951dd4dfab5ab97d565a496292022-12-22T04:14:00ZengElsevierJACC: Basic to Translational Science2452-302X2022-11-0171110691082Determinants of Endogenous Fibrinolysis in Whole Blood Under High Shear in Patients With Myocardial InfarctionRahim Kanji, MB, BS0Ying X. Gue, MB, BS, PhD1Mohamed F. Farag, MB, BS, PhD2Neil H. Spencer, PhD3Nicola J. Mutch, BSc, PhD4Diana A. Gorog, MD, PhD5Faculty of Medicine, National Heart and Lung Institute, Imperial College, London, United Kingdom; Cardiology Department, East and North Hertfordshire NHS Trust, Stevenage, Hertfordshire, United KingdomCardiology Department, East and North Hertfordshire NHS Trust, Stevenage, Hertfordshire, United Kingdom; School of Life and Medical Sciences, Postgraduate Medical School, University of Hertfordshire, Hatfield, Hertfordshire, United KingdomCardiology Department, East and North Hertfordshire NHS Trust, Stevenage, Hertfordshire, United Kingdom; School of Life and Medical Sciences, Postgraduate Medical School, University of Hertfordshire, Hatfield, Hertfordshire, United KingdomStatistical Services and Consultancy Unit, Hertfordshire Business School, University of Hertfordshire, Hatfield, Hertfordshire, United KingdomAberdeen Cardiovascular and Diabetes Centre, Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, United KingdomFaculty of Medicine, National Heart and Lung Institute, Imperial College, London, United Kingdom; Cardiology Department, East and North Hertfordshire NHS Trust, Stevenage, Hertfordshire, United Kingdom; School of Life and Medical Sciences, Postgraduate Medical School, University of Hertfordshire, Hatfield, Hertfordshire, United Kingdom; Address for correspondence: Prof Diana A. Gorog, Faculty of Medicine, National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, United Kingdom.Summary: Hypofibrinolysis is a recently-recognized risk factor for recurrent cardiovascular events in patients with ST-segment elevation myocardial infarction (STEMI), but the mechanistic determinants of this are not well understood. In patients with STEMI, we show that the effectiveness of endogenous fibrinolysis in whole blood is determined in part by fibrinogen level, high sensitivity C-reactive protein, and shear-induced platelet reactivity, the latter directly related to the speed of thrombin generation. Our findings strengthen the evidence for the role of cellular components and bidirectional crosstalk between coagulatory and inflammatory pathways as determinants of hypofibrinolysis.http://www.sciencedirect.com/science/article/pii/S2452302X22002145fibrinolysismyocardial infarctionplatelet functionthrombosis |
| spellingShingle | Rahim Kanji, MB, BS Ying X. Gue, MB, BS, PhD Mohamed F. Farag, MB, BS, PhD Neil H. Spencer, PhD Nicola J. Mutch, BSc, PhD Diana A. Gorog, MD, PhD Determinants of Endogenous Fibrinolysis in Whole Blood Under High Shear in Patients With Myocardial Infarction JACC: Basic to Translational Science fibrinolysis myocardial infarction platelet function thrombosis |
| title | Determinants of Endogenous Fibrinolysis in Whole Blood Under High Shear in Patients With Myocardial Infarction |
| title_full | Determinants of Endogenous Fibrinolysis in Whole Blood Under High Shear in Patients With Myocardial Infarction |
| title_fullStr | Determinants of Endogenous Fibrinolysis in Whole Blood Under High Shear in Patients With Myocardial Infarction |
| title_full_unstemmed | Determinants of Endogenous Fibrinolysis in Whole Blood Under High Shear in Patients With Myocardial Infarction |
| title_short | Determinants of Endogenous Fibrinolysis in Whole Blood Under High Shear in Patients With Myocardial Infarction |
| title_sort | determinants of endogenous fibrinolysis in whole blood under high shear in patients with myocardial infarction |
| topic | fibrinolysis myocardial infarction platelet function thrombosis |
| url | http://www.sciencedirect.com/science/article/pii/S2452302X22002145 |
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