ADAMDEC1 and FGF2/FGFR1 signaling constitute a positive feedback loop to maintain GBM cancer stem cells

ADAMDEC1 and FGF2/FGFR1 signaling constitute a positive feedback loop to maintain GBM cancer stem cells

Identification of targetable mechanisms that maintain glioblastoma cancer stem cells (CSCs) remain a priority. Our study reveals a new mechanism by which a disintegrin and metalloproteinase domain-like protein decysin 1 promotes CSC maintenance through the activation of a fibroblast growth factor au...

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Bibliographic Details
Main Authors: Ana Jimenez-Pascual, Justin D. Lathia, Florian A. Siebzehnrubl
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Molecular & Cellular Oncology
Subjects:
fgfr1
fgf2
zeb1
patient-derived xenograft
glioblastoma
Online Access:http://dx.doi.org/10.1080/23723556.2019.1684787

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