Endoscopic management versus radical nephroureterectomy for localized upper tract urothelial carcinoma in a high endemic region
Abstract Our aim was to analyze the clinical and survival differences among patients who underwent the two main treatment modalities, endoscopic ablation and radical nephroureterectomy. This study examined all patients who had undergone endoscopic management and RNU between Jul. 1988 and Mar. 2019 f...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
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Nature Portfolio
2021-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-83495-4 |
| _version_ | 1818432268818972672 |
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| author | Yung-Tai Chen Chih-Chin Yu Hsin-Chih Yeh Hsiang-Ying Lee Yuan-Hong Jiang Yu-Khun Lee Chia-Hao Kuei Chia-Chang Wu Chao-Yuan Huang Wei-Yu Lin Cheng Kuang Yang Yao Chou Tsai |
| author_facet | Yung-Tai Chen Chih-Chin Yu Hsin-Chih Yeh Hsiang-Ying Lee Yuan-Hong Jiang Yu-Khun Lee Chia-Hao Kuei Chia-Chang Wu Chao-Yuan Huang Wei-Yu Lin Cheng Kuang Yang Yao Chou Tsai |
| author_sort | Yung-Tai Chen |
| collection | DOAJ |
| description | Abstract Our aim was to analyze the clinical and survival differences among patients who underwent the two main treatment modalities, endoscopic ablation and radical nephroureterectomy. This study examined all patients who had undergone endoscopic management and RNU between Jul. 1988 and Mar. 2019 from the Taiwan UTUC registry. The inclusion criteria were low stage UTUC in RNU and all cases in endoscopic managed UTUC with a curative intent. The demographic and clinical characteristics were included for analysis. In total, 84 cases in the endoscopic group and 272 cases in the RNU group were enrolled for final analysis. The median follow-up period were 33.5 and 42.0 months in endoscopic and RNU group, respectively (p = 0.082). Comparison of Kaplan–Meier estimated survival curves between groups, the endoscopic group was associated with similar overall survival (OS), cancer specific survival (CSS), and intravesical recurrence free survival (IVRS) but demonstrated inferior disease free survival (DFS) (p = 0.188 for OS, p = 0.493 for CSS and p < 0.001 for DFS). Endoscopic management of UTUC was as safe as RNU in UTUC endemic region. |
| first_indexed | 2024-12-14T16:02:30Z |
| format | Article |
| id | doaj.art-edb0342392fb438b8c253c7d3999360a |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T16:02:30Z |
| publishDate | 2021-02-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj.art-edb0342392fb438b8c253c7d3999360a2022-12-21T22:55:10ZengNature PortfolioScientific Reports2045-23222021-02-0111111010.1038/s41598-021-83495-4Endoscopic management versus radical nephroureterectomy for localized upper tract urothelial carcinoma in a high endemic regionYung-Tai Chen0Chih-Chin Yu1Hsin-Chih Yeh2Hsiang-Ying Lee3Yuan-Hong Jiang4Yu-Khun Lee5Chia-Hao Kuei6Chia-Chang Wu7Chao-Yuan Huang8Wei-Yu Lin9Cheng Kuang Yang10Yao Chou Tsai11Department of Urology, Postal HospitalDivision of Urology, Department of Surgery, Taipei Tzuchi Hospital, The Buddhist Tzu Chi Medical FoundationDepartment of Urology, Kaohsiung Municipal Ta-Tung HospitalDepartment of Urology, Kaohsiung Municipal Ta-Tung HospitalDepartment of Urology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi UniversityDepartment of Urology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi UniversityDivision of Urology, Department of Surgery, Cardinal Tien HospitalDepartment of Urology, Shuang Ho Hospital, Taipei Medical UniversityDepartment of Urology, National Taiwan University Hospital, College of Medicine, National Taiwan UniversityDivision of Urology, Department of Surgery, Chang Gung Memorial HospitalDepartment of Urology, School of Medicine, College of Medicine, Taipei Medical UniversityDepartment of Urology, School of Medicine, College of Medicine, Taipei Medical UniversityAbstract Our aim was to analyze the clinical and survival differences among patients who underwent the two main treatment modalities, endoscopic ablation and radical nephroureterectomy. This study examined all patients who had undergone endoscopic management and RNU between Jul. 1988 and Mar. 2019 from the Taiwan UTUC registry. The inclusion criteria were low stage UTUC in RNU and all cases in endoscopic managed UTUC with a curative intent. The demographic and clinical characteristics were included for analysis. In total, 84 cases in the endoscopic group and 272 cases in the RNU group were enrolled for final analysis. The median follow-up period were 33.5 and 42.0 months in endoscopic and RNU group, respectively (p = 0.082). Comparison of Kaplan–Meier estimated survival curves between groups, the endoscopic group was associated with similar overall survival (OS), cancer specific survival (CSS), and intravesical recurrence free survival (IVRS) but demonstrated inferior disease free survival (DFS) (p = 0.188 for OS, p = 0.493 for CSS and p < 0.001 for DFS). Endoscopic management of UTUC was as safe as RNU in UTUC endemic region.https://doi.org/10.1038/s41598-021-83495-4 |
| spellingShingle | Yung-Tai Chen Chih-Chin Yu Hsin-Chih Yeh Hsiang-Ying Lee Yuan-Hong Jiang Yu-Khun Lee Chia-Hao Kuei Chia-Chang Wu Chao-Yuan Huang Wei-Yu Lin Cheng Kuang Yang Yao Chou Tsai Endoscopic management versus radical nephroureterectomy for localized upper tract urothelial carcinoma in a high endemic region Scientific Reports |
| title | Endoscopic management versus radical nephroureterectomy for localized upper tract urothelial carcinoma in a high endemic region |
| title_full | Endoscopic management versus radical nephroureterectomy for localized upper tract urothelial carcinoma in a high endemic region |
| title_fullStr | Endoscopic management versus radical nephroureterectomy for localized upper tract urothelial carcinoma in a high endemic region |
| title_full_unstemmed | Endoscopic management versus radical nephroureterectomy for localized upper tract urothelial carcinoma in a high endemic region |
| title_short | Endoscopic management versus radical nephroureterectomy for localized upper tract urothelial carcinoma in a high endemic region |
| title_sort | endoscopic management versus radical nephroureterectomy for localized upper tract urothelial carcinoma in a high endemic region |
| url | https://doi.org/10.1038/s41598-021-83495-4 |
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