Lys417 acts as a molecular switch that regulates the conformation of SARS-CoV-2 spike protein

Lys417 acts as a molecular switch that regulates the conformation of SARS-CoV-2 spike protein

SARS-CoV-2 spike protein plays a key role in mediating viral entry and inducing host immune responses. It can adopt either an open or closed conformation based on the position of its receptor-binding domain (RBD). It is yet unclear what causes these conformational changes or how they influence the s...

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Bibliographic Details
Main Authors: Qibin Geng, Yushun Wan, Fu-Chun Hsueh, Jian Shang, Gang Ye, Fan Bu, Morgan Herbst, Rowan Wilkens, Bin Liu, Fang Li
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-11-01
Series:eLife
Subjects:
SARS-CoV-2
spike protein
viral entry
immune evasiveness
receptor-binding domain
Online Access:https://elifesciences.org/articles/74060

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