Expanding the Disorder-Function Paradigm in the C-Terminal Tails of Erbbs

Expanding the Disorder-Function Paradigm in the C-Terminal Tails of Erbbs

ErbBs are receptor tyrosine kinases involved not only in development, but also in a wide variety of diseases, particularly cancer. Their extracellular, transmembrane, juxtamembrane, and kinase folded domains were described extensively over the past 20 years, structurally and functionally. However, t...

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Bibliographic Details
Main Authors: Louise Pinet, Nadine Assrir, Carine van Heijenoort
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Biomolecules
Subjects:
intrinsic disorder
signal transduction
receptor tyrosine kinases
ErbB
EGFR
HER
Online Access:https://www.mdpi.com/2218-273X/11/11/1690

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