Mast cell stabilizer ketotifen fumarate reverses inflammatory but not neuropathic-induced mechanical pain in mice

Mast cell stabilizer ketotifen fumarate reverses inflammatory but not neuropathic-induced mechanical pain in mice

Abstract. Introduction:. Mast cell (MC) activation could establish a positive feedback loop that perpetuates inflammation and maintains pain. Stabilizing MCs with ketotifen fumarate (KF) may disrupt this loop and relieve pain. Objective:. We aimed to test the effect of treatment with KF in pain assa...

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Bibliographic Details
Main Authors: Carolina B. Meloto, Pablo Ingelmo, Eduardo Vega Perez, Rebecca Pitt, Víctor Hugo González Cárdenas, Nada Mohamed, Susana G. Sotocinal, Valerie Bourassa, Lucas Vasconcelos Lima, Alfredo Ribeiro-da-Silva, Jeffrey S. Mogil, Luda Diatchenko
Format: Article
Language:English
Published: Wolters Kluwer 2021-07-01
Series:PAIN Reports
Online Access:http://journals.lww.com/painrpts/fulltext/10.1097/PR9.0000000000000902

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