Non-Coding RNAs as Potential Neuroprotectants against Ischemic Brain Injury
Over the past decade, scientific discoveries have highlighted new roles for a unique class of non-coding RNAs. Transcribed from the genome, these non-coding RNAs have been implicated in determining the biological complexity seen in mammals by acting as transcriptional and translational regulators. N...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2013-03-01
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| Series: | Brain Sciences |
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| Online Access: | http://www.mdpi.com/2076-3425/3/1/360 |
| _version_ | 1818534477846020096 |
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| author | Fujia Liu Jun Rong Tan Kai Ying Lim Sugunavathi Sepramaniam Dwi Setyowati Karolina Arunmozhiarasi Armugam Kandiah Jeyaseelan Prameet Kaur |
| author_facet | Fujia Liu Jun Rong Tan Kai Ying Lim Sugunavathi Sepramaniam Dwi Setyowati Karolina Arunmozhiarasi Armugam Kandiah Jeyaseelan Prameet Kaur |
| author_sort | Fujia Liu |
| collection | DOAJ |
| description | Over the past decade, scientific discoveries have highlighted new roles for a unique class of non-coding RNAs. Transcribed from the genome, these non-coding RNAs have been implicated in determining the biological complexity seen in mammals by acting as transcriptional and translational regulators. Non-coding RNAs, which can be sub-classified into long non-coding RNAs, microRNAs, PIWI-interacting RNAs and several others, are widely expressed in the nervous system with roles in neurogenesis, development and maintenance of the neuronal phenotype. Perturbations of these non-coding transcripts have been observed in ischemic preconditioning as well as ischemic brain injury with characterization of the mechanisms by which they confer toxicity. Their dysregulation may also confer pathogenic conditions in neurovascular diseases. A better understanding of their expression patterns and functions has uncovered the potential use of these riboregulators as neuroprotectants to antagonize the detrimental molecular events taking place upon ischemic-reperfusion injury. In this review, we discuss the various roles of non-coding RNAs in brain development and their mechanisms of gene regulation in relation to ischemic brain injury. We will also address the future directions and open questions for identifying promising non-coding RNAs that could eventually serve as potential neuroprotectants against ischemic brain injury. |
| first_indexed | 2024-12-11T18:12:09Z |
| format | Article |
| id | doaj.art-edb5f0cf592e416c8d9b7a66d60dd08b |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-12-11T18:12:09Z |
| publishDate | 2013-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-edb5f0cf592e416c8d9b7a66d60dd08b2022-12-22T00:55:33ZengMDPI AGBrain Sciences2076-34252013-03-013136039510.3390/brainsci3010360Non-Coding RNAs as Potential Neuroprotectants against Ischemic Brain InjuryFujia LiuJun Rong TanKai Ying LimSugunavathi SepramaniamDwi Setyowati KarolinaArunmozhiarasi ArmugamKandiah JeyaseelanPrameet KaurOver the past decade, scientific discoveries have highlighted new roles for a unique class of non-coding RNAs. Transcribed from the genome, these non-coding RNAs have been implicated in determining the biological complexity seen in mammals by acting as transcriptional and translational regulators. Non-coding RNAs, which can be sub-classified into long non-coding RNAs, microRNAs, PIWI-interacting RNAs and several others, are widely expressed in the nervous system with roles in neurogenesis, development and maintenance of the neuronal phenotype. Perturbations of these non-coding transcripts have been observed in ischemic preconditioning as well as ischemic brain injury with characterization of the mechanisms by which they confer toxicity. Their dysregulation may also confer pathogenic conditions in neurovascular diseases. A better understanding of their expression patterns and functions has uncovered the potential use of these riboregulators as neuroprotectants to antagonize the detrimental molecular events taking place upon ischemic-reperfusion injury. In this review, we discuss the various roles of non-coding RNAs in brain development and their mechanisms of gene regulation in relation to ischemic brain injury. We will also address the future directions and open questions for identifying promising non-coding RNAs that could eventually serve as potential neuroprotectants against ischemic brain injury.http://www.mdpi.com/2076-3425/3/1/360non-coding RNAsneuroprotectantischemiabrainmiRNAlncRNApiRNA |
| spellingShingle | Fujia Liu Jun Rong Tan Kai Ying Lim Sugunavathi Sepramaniam Dwi Setyowati Karolina Arunmozhiarasi Armugam Kandiah Jeyaseelan Prameet Kaur Non-Coding RNAs as Potential Neuroprotectants against Ischemic Brain Injury Brain Sciences non-coding RNAs neuroprotectant ischemia brain miRNA lncRNA piRNA |
| title | Non-Coding RNAs as Potential Neuroprotectants against Ischemic Brain Injury |
| title_full | Non-Coding RNAs as Potential Neuroprotectants against Ischemic Brain Injury |
| title_fullStr | Non-Coding RNAs as Potential Neuroprotectants against Ischemic Brain Injury |
| title_full_unstemmed | Non-Coding RNAs as Potential Neuroprotectants against Ischemic Brain Injury |
| title_short | Non-Coding RNAs as Potential Neuroprotectants against Ischemic Brain Injury |
| title_sort | non coding rnas as potential neuroprotectants against ischemic brain injury |
| topic | non-coding RNAs neuroprotectant ischemia brain miRNA lncRNA piRNA |
| url | http://www.mdpi.com/2076-3425/3/1/360 |
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