Recreational drug poisoning with gamma-butyrolactone and 1,4-butanediol in Taiwan
Restriction of gamma-hydroxybutyrate (GHB) in 1990 resulted in a shift toward the use of gamma-butyrolactone (GBL) or 1,4-butanediol (1,4-BD), which remain unregulated in most countries, including Taiwan. Self-reported GBL and 1,4-BD use are less common than GHB use, and the prevalence of GBL or 1,4...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Journal of Medical Sciences |
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| Online Access: | http://www.jmedscindmc.com/article.asp?issn=1011-4564;year=2023;volume=43;issue=3;spage=140;epage=143;aulast=Chen |
| _version_ | 1827894786103705600 |
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| author | Feng-Chen Chen Yan-Chiao Mao Jou-Fang Deng Cheng-Hsuan Ho |
| author_facet | Feng-Chen Chen Yan-Chiao Mao Jou-Fang Deng Cheng-Hsuan Ho |
| author_sort | Feng-Chen Chen |
| collection | DOAJ |
| description | Restriction of gamma-hydroxybutyrate (GHB) in 1990 resulted in a shift toward the use of gamma-butyrolactone (GBL) or 1,4-butanediol (1,4-BD), which remain unregulated in most countries, including Taiwan. Self-reported GBL and 1,4-BD use are less common than GHB use, and the prevalence of GBL or 1,4-BD abuse may be underestimated. The first patient, a 45-year-old male, used GBL to enhance his sexual activity. He developed respiratory system and central nervous system (CNS) suppression; he was intubated and admitted to the intensive care unit. His urine GHB concentration was 289.5 mg/L. The second patient was a 24-year-old male who used 1,4-BD in conjunction with mixed new psychoactive substances to enhance his sexual activity. He also developed CNS suppression, and his urine GHB concentration was 1192.4 mg/L. By reporting these cases, we highlight the recreational use of GHB precursors, such as GBL and 1,4-BD, which is relatively unfamiliar to clinicians. Patients may present with CNS and respiratory depression after the voluntary recreational use of these drugs. |
| first_indexed | 2024-03-12T22:12:09Z |
| format | Article |
| id | doaj.art-edb6977e1c8c4419b85cd37cf7fde9eb |
| institution | Directory Open Access Journal |
| issn | 1011-4564 |
| language | English |
| last_indexed | 2024-03-12T22:12:09Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Medical Sciences |
| spelling | doaj.art-edb6977e1c8c4419b85cd37cf7fde9eb2023-07-23T11:41:54ZengWolters Kluwer Medknow PublicationsJournal of Medical Sciences1011-45642023-01-0143314014310.4103/jmedsci.jmedsci_138_22Recreational drug poisoning with gamma-butyrolactone and 1,4-butanediol in TaiwanFeng-Chen ChenYan-Chiao MaoJou-Fang DengCheng-Hsuan HoRestriction of gamma-hydroxybutyrate (GHB) in 1990 resulted in a shift toward the use of gamma-butyrolactone (GBL) or 1,4-butanediol (1,4-BD), which remain unregulated in most countries, including Taiwan. Self-reported GBL and 1,4-BD use are less common than GHB use, and the prevalence of GBL or 1,4-BD abuse may be underestimated. The first patient, a 45-year-old male, used GBL to enhance his sexual activity. He developed respiratory system and central nervous system (CNS) suppression; he was intubated and admitted to the intensive care unit. His urine GHB concentration was 289.5 mg/L. The second patient was a 24-year-old male who used 1,4-BD in conjunction with mixed new psychoactive substances to enhance his sexual activity. He also developed CNS suppression, and his urine GHB concentration was 1192.4 mg/L. By reporting these cases, we highlight the recreational use of GHB precursors, such as GBL and 1,4-BD, which is relatively unfamiliar to clinicians. Patients may present with CNS and respiratory depression after the voluntary recreational use of these drugs.http://www.jmedscindmc.com/article.asp?issn=1011-4564;year=2023;volume=43;issue=3;spage=140;epage=143;aulast=Chengamma hydroxybutyrategamma butyrolactone14-butanediolrecreational drug |
| spellingShingle | Feng-Chen Chen Yan-Chiao Mao Jou-Fang Deng Cheng-Hsuan Ho Recreational drug poisoning with gamma-butyrolactone and 1,4-butanediol in Taiwan Journal of Medical Sciences gamma hydroxybutyrate gamma butyrolactone 1 4-butanediol recreational drug |
| title | Recreational drug poisoning with gamma-butyrolactone and 1,4-butanediol in Taiwan |
| title_full | Recreational drug poisoning with gamma-butyrolactone and 1,4-butanediol in Taiwan |
| title_fullStr | Recreational drug poisoning with gamma-butyrolactone and 1,4-butanediol in Taiwan |
| title_full_unstemmed | Recreational drug poisoning with gamma-butyrolactone and 1,4-butanediol in Taiwan |
| title_short | Recreational drug poisoning with gamma-butyrolactone and 1,4-butanediol in Taiwan |
| title_sort | recreational drug poisoning with gamma butyrolactone and 1 4 butanediol in taiwan |
| topic | gamma hydroxybutyrate gamma butyrolactone 1 4-butanediol recreational drug |
| url | http://www.jmedscindmc.com/article.asp?issn=1011-4564;year=2023;volume=43;issue=3;spage=140;epage=143;aulast=Chen |
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