Rapid detection and monitoring of human coronavirus infections
Human coronaviruses (CoVs) are increasingly recognized as important respiratory pathogens associated with a broad range of clinical diseases. We sought to increase the insight into clinically relevant CoV infections by monitoring antigen concentrations in six confirmed CoV-positive patients using a...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-07-01
|
| Series: | New Microbes and New Infections |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2052297518300350 |
| _version_ | 1819063244325650432 |
|---|---|
| author | A.H.L. Bruning H. Aatola H. Toivola N. Ikonen C. Savolainen-Kopra S. Blomqvist D. Pajkrt K.C. Wolthers J.O. Koskinen |
| author_facet | A.H.L. Bruning H. Aatola H. Toivola N. Ikonen C. Savolainen-Kopra S. Blomqvist D. Pajkrt K.C. Wolthers J.O. Koskinen |
| author_sort | A.H.L. Bruning |
| collection | DOAJ |
| description | Human coronaviruses (CoVs) are increasingly recognized as important respiratory pathogens associated with a broad range of clinical diseases. We sought to increase the insight into clinically relevant CoV infections by monitoring antigen concentrations in six confirmed CoV-positive patients using a newly developed assay for rapid detection of CoV OC43 infections. Antigen positivity lasted 3 to 6 days in secondary infections and 13 days in primary infection. CoV infections are clinically diverse, are common, and cannot be diagnosed from clinical symptoms alone. Keywords: Human coronavirus, point-of-care test, rapid antigen test, rapid detection, respiratory tract infection |
| first_indexed | 2024-12-21T15:11:36Z |
| format | Article |
| id | doaj.art-edb97cd248a94aa4a2db1666eb9ec960 |
| institution | Directory Open Access Journal |
| issn | 2052-2975 |
| language | English |
| last_indexed | 2024-12-21T15:11:36Z |
| publishDate | 2018-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | New Microbes and New Infections |
| spelling | doaj.art-edb97cd248a94aa4a2db1666eb9ec9602022-12-21T18:59:17ZengElsevierNew Microbes and New Infections2052-29752018-07-01245255Rapid detection and monitoring of human coronavirus infectionsA.H.L. Bruning0H. Aatola1H. Toivola2N. Ikonen3C. Savolainen-Kopra4S. Blomqvist5D. Pajkrt6K.C. Wolthers7J.O. Koskinen8Department of Medical Microbiology, Academic Medical Center, Amsterdam, The Netherlands; Corresponding author: A. H. L. Bruning, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.ArcDia International Oy Ltd, Turku, FinlandArcDia International Oy Ltd, Turku, FinlandNational Institute for Health and Welfare (THL), Helsinki, FinlandNational Institute for Health and Welfare (THL), Helsinki, FinlandNational Institute for Health and Welfare (THL), Helsinki, FinlandDepartment of Pediatric Infectious Diseases, Emma Children's Hospital, Academic Medical Center, Amsterdam, The NetherlandsDepartment of Medical Microbiology, Academic Medical Center, Amsterdam, The NetherlandsArcDia International Oy Ltd, Turku, FinlandHuman coronaviruses (CoVs) are increasingly recognized as important respiratory pathogens associated with a broad range of clinical diseases. We sought to increase the insight into clinically relevant CoV infections by monitoring antigen concentrations in six confirmed CoV-positive patients using a newly developed assay for rapid detection of CoV OC43 infections. Antigen positivity lasted 3 to 6 days in secondary infections and 13 days in primary infection. CoV infections are clinically diverse, are common, and cannot be diagnosed from clinical symptoms alone. Keywords: Human coronavirus, point-of-care test, rapid antigen test, rapid detection, respiratory tract infectionhttp://www.sciencedirect.com/science/article/pii/S2052297518300350 |
| spellingShingle | A.H.L. Bruning H. Aatola H. Toivola N. Ikonen C. Savolainen-Kopra S. Blomqvist D. Pajkrt K.C. Wolthers J.O. Koskinen Rapid detection and monitoring of human coronavirus infections New Microbes and New Infections |
| title | Rapid detection and monitoring of human coronavirus infections |
| title_full | Rapid detection and monitoring of human coronavirus infections |
| title_fullStr | Rapid detection and monitoring of human coronavirus infections |
| title_full_unstemmed | Rapid detection and monitoring of human coronavirus infections |
| title_short | Rapid detection and monitoring of human coronavirus infections |
| title_sort | rapid detection and monitoring of human coronavirus infections |
| url | http://www.sciencedirect.com/science/article/pii/S2052297518300350 |
| work_keys_str_mv | AT ahlbruning rapiddetectionandmonitoringofhumancoronavirusinfections AT haatola rapiddetectionandmonitoringofhumancoronavirusinfections AT htoivola rapiddetectionandmonitoringofhumancoronavirusinfections AT nikonen rapiddetectionandmonitoringofhumancoronavirusinfections AT csavolainenkopra rapiddetectionandmonitoringofhumancoronavirusinfections AT sblomqvist rapiddetectionandmonitoringofhumancoronavirusinfections AT dpajkrt rapiddetectionandmonitoringofhumancoronavirusinfections AT kcwolthers rapiddetectionandmonitoringofhumancoronavirusinfections AT jokoskinen rapiddetectionandmonitoringofhumancoronavirusinfections |