The utility of two-dimensional shear wave elastography for predicting prostate cancer: a preliminary study
Purpose This study investigated whether two-dimensional shear wave elastography (2D-SWE), using a newly developed device, is useful for predicting prostate cancer (PCa). Methods In this prospective study, 38 patients with suspected PCa underwent 2D-SWE, followed by a standard systematic 12-core biop...
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| Format: | Article |
| Language: | English |
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Korean Society of Ultrasound in Medicine
2023-07-01
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| Series: | Ultrasonography |
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| Online Access: | http://www.e-ultrasonography.org/upload/usg-22202.pdf |
| _version_ | 1797789183319736320 |
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| author | Seong Soo Jeon Chan Kyo Kim Sung Yoon Park Jae Hoon Chung Minyong Kang Hyun Hwan Sung Byong Chang Jeong |
| author_facet | Seong Soo Jeon Chan Kyo Kim Sung Yoon Park Jae Hoon Chung Minyong Kang Hyun Hwan Sung Byong Chang Jeong |
| author_sort | Seong Soo Jeon |
| collection | DOAJ |
| description | Purpose This study investigated whether two-dimensional shear wave elastography (2D-SWE), using a newly developed device, is useful for predicting prostate cancer (PCa). Methods In this prospective study, 38 patients with suspected PCa underwent 2D-SWE, followed by a standard systematic 12-core biopsy with and without a targeted biopsy. Tissue stiffness on SWE was measured in the target lesion and in 12 regions of the systematic biopsies, and the maximum (Emax), mean (Emean), and minimum (Emin) values of stiffness were generated. The area under the receiver operating characteristic curve (AUROC) for predicting clinically significant cancer (CSC) was calculated. Interobserver reliability and variability were evaluated using the intraclass correlation coefficient (ICC) and Bland-Altman plots, respectively. Results PCa was found in 78 of 488 regions (16%) in 17 patients. In region-based and patientbased analyses, the Emax, Emean, and Emin values of PCa were significantly higher than those of benign prostate tissue (P<0.001). For the prediction of CSC, the AUROCs of Emax, Emean, and Emin in the patient-based analysis were 0.865, 0.855, and 0.828, while that of prostate-specific antigen density was 0.749. In the region-based analysis, the AUROCs of Emax, Emean, and Emin values were 0.772, 0.776, and 0.727, respectively. The interobserver reliability for the SWE parameters was moderate to good (ICC, 0.542 to 0.769), and the mean percentage differences on Bland-Altman plots were less than 7.0%. Conclusion The 2D-SWE method appears to be a reproducible and useful tool for the prediction of PCa. A larger study is warranted for further validation. |
| first_indexed | 2024-03-13T01:47:06Z |
| format | Article |
| id | doaj.art-edbb2bbaedae49bb90b2928ac80b0b98 |
| institution | Directory Open Access Journal |
| issn | 2288-5943 |
| language | English |
| last_indexed | 2024-03-13T01:47:06Z |
| publishDate | 2023-07-01 |
| publisher | Korean Society of Ultrasound in Medicine |
| record_format | Article |
| series | Ultrasonography |
| spelling | doaj.art-edbb2bbaedae49bb90b2928ac80b0b982023-07-03T07:54:07ZengKorean Society of Ultrasound in MedicineUltrasonography2288-59432023-07-0142340040910.14366/usg.222021662The utility of two-dimensional shear wave elastography for predicting prostate cancer: a preliminary studySeong Soo Jeon0Chan Kyo Kim1Sung Yoon Park2Jae Hoon Chung3Minyong Kang4Hyun Hwan Sung5Byong Chang Jeong6 Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaPurpose This study investigated whether two-dimensional shear wave elastography (2D-SWE), using a newly developed device, is useful for predicting prostate cancer (PCa). Methods In this prospective study, 38 patients with suspected PCa underwent 2D-SWE, followed by a standard systematic 12-core biopsy with and without a targeted biopsy. Tissue stiffness on SWE was measured in the target lesion and in 12 regions of the systematic biopsies, and the maximum (Emax), mean (Emean), and minimum (Emin) values of stiffness were generated. The area under the receiver operating characteristic curve (AUROC) for predicting clinically significant cancer (CSC) was calculated. Interobserver reliability and variability were evaluated using the intraclass correlation coefficient (ICC) and Bland-Altman plots, respectively. Results PCa was found in 78 of 488 regions (16%) in 17 patients. In region-based and patientbased analyses, the Emax, Emean, and Emin values of PCa were significantly higher than those of benign prostate tissue (P<0.001). For the prediction of CSC, the AUROCs of Emax, Emean, and Emin in the patient-based analysis were 0.865, 0.855, and 0.828, while that of prostate-specific antigen density was 0.749. In the region-based analysis, the AUROCs of Emax, Emean, and Emin values were 0.772, 0.776, and 0.727, respectively. The interobserver reliability for the SWE parameters was moderate to good (ICC, 0.542 to 0.769), and the mean percentage differences on Bland-Altman plots were less than 7.0%. Conclusion The 2D-SWE method appears to be a reproducible and useful tool for the prediction of PCa. A larger study is warranted for further validation.http://www.e-ultrasonography.org/upload/usg-22202.pdfprostatic neoplasmsshear wave elastographyultrasoundyoung’s modulus |
| spellingShingle | Seong Soo Jeon Chan Kyo Kim Sung Yoon Park Jae Hoon Chung Minyong Kang Hyun Hwan Sung Byong Chang Jeong The utility of two-dimensional shear wave elastography for predicting prostate cancer: a preliminary study Ultrasonography prostatic neoplasms shear wave elastography ultrasound young’s modulus |
| title | The utility of two-dimensional shear wave elastography for predicting prostate cancer: a preliminary study |
| title_full | The utility of two-dimensional shear wave elastography for predicting prostate cancer: a preliminary study |
| title_fullStr | The utility of two-dimensional shear wave elastography for predicting prostate cancer: a preliminary study |
| title_full_unstemmed | The utility of two-dimensional shear wave elastography for predicting prostate cancer: a preliminary study |
| title_short | The utility of two-dimensional shear wave elastography for predicting prostate cancer: a preliminary study |
| title_sort | utility of two dimensional shear wave elastography for predicting prostate cancer a preliminary study |
| topic | prostatic neoplasms shear wave elastography ultrasound young’s modulus |
| url | http://www.e-ultrasonography.org/upload/usg-22202.pdf |
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