Frailty in Traumatic Brain Injury—The Significance of Temporal Muscle Thickness
Background: Temporal muscle thickness (TMT) on cranial CT scans has recently been identified as a prognostic imaging parameter for assessing a patient’s baseline frailty. Here, we analyzed whether TMT correlates with Traumatic brain injury (TBI) severity and whether it can be used to predict outcome...
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| Format: | Article |
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MDPI AG
2023-12-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/24/7625 |
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| author | Daniel Dubinski Sae-Yeon Won Jonas Meyer-Wilmes Svorad Trnovec Artem Rafaelian Bedjan Behmanesh Daniel Cantré Peter Baumgarten Nazife Dinc Juergen Konczalla Matthias Wittstock Joshua D. Bernstock Thomas M. Freiman Florian Gessler |
| author_facet | Daniel Dubinski Sae-Yeon Won Jonas Meyer-Wilmes Svorad Trnovec Artem Rafaelian Bedjan Behmanesh Daniel Cantré Peter Baumgarten Nazife Dinc Juergen Konczalla Matthias Wittstock Joshua D. Bernstock Thomas M. Freiman Florian Gessler |
| author_sort | Daniel Dubinski |
| collection | DOAJ |
| description | Background: Temporal muscle thickness (TMT) on cranial CT scans has recently been identified as a prognostic imaging parameter for assessing a patient’s baseline frailty. Here, we analyzed whether TMT correlates with Traumatic brain injury (TBI) severity and whether it can be used to predict outcome(s) after TBI. Methods: We analyzed the radiological and clinical data sets of 193 patients with TBI who were admitted to our institution and correlated the radiological data with clinical outcomes after stratification for TMT. Results: Our analyses showed a significant association between high TMT and increased risk for intracranial hemorrhage (<i>p</i> = 0.0135) but improved mRS at 6 months (<i>p</i> = 0.001) as compared to patients with low TMT. Congruent with such findings, a lower TMT was associated with falls and reduced outcomes at 6 months (<i>p</i> < 0.0001 and <i>p</i> < 0.0001). Conclusion: High TMT was robustly associated with head trauma sequelae but was also associated with good clinical outcomes in TBI patients. These findings consolidate the significance of TMT as an objective marker of frailty in TBI patients; such measurements may ultimately be leveraged as prognostic indicators. |
| first_indexed | 2024-03-08T20:39:22Z |
| format | Article |
| id | doaj.art-edbbd1984b3f4190a1495826e333bd68 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-08T20:39:22Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-edbbd1984b3f4190a1495826e333bd682023-12-22T14:17:13ZengMDPI AGJournal of Clinical Medicine2077-03832023-12-011224762510.3390/jcm12247625Frailty in Traumatic Brain Injury—The Significance of Temporal Muscle ThicknessDaniel Dubinski0Sae-Yeon Won1Jonas Meyer-Wilmes2Svorad Trnovec3Artem Rafaelian4Bedjan Behmanesh5Daniel Cantré6Peter Baumgarten7Nazife Dinc8Juergen Konczalla9Matthias Wittstock10Joshua D. Bernstock11Thomas M. Freiman12Florian Gessler13Department of Neurosurgery, University Medicine Rostock, 18057 Rostock, GermanyDepartment of Neurosurgery, University Medicine Rostock, 18057 Rostock, GermanyDepartment of Neurosurgery, University Medicine Rostock, 18057 Rostock, GermanyDepartment of Neurosurgery, University Medicine Rostock, 18057 Rostock, GermanyDepartment of Neurosurgery, University Medicine Rostock, 18057 Rostock, GermanyDepartment of Neurosurgery, University Medicine Rostock, 18057 Rostock, GermanyInstitute of Diagnostic and Interventional Radiology, Pediatric Radiology and Neuroradiology, University Medicine Rostock, 18057 Rostock, GermanyDepartment of Neurosurgery, University Hospital, Schiller University Jena, 07747 Jena, GermanyDepartment of Neurosurgery, University Hospital, Schiller University Jena, 07747 Jena, GermanyDepartment of Neurosurgery, Goethe-University Hospital, 60596 Frankfurt am Main, GermanyDepartment of Neurology, University Medicine Rostock, 18057 Rostock, GermanyDepartment of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USADepartment of Neurosurgery, University Medicine Rostock, 18057 Rostock, GermanyDepartment of Neurosurgery, University Medicine Rostock, 18057 Rostock, GermanyBackground: Temporal muscle thickness (TMT) on cranial CT scans has recently been identified as a prognostic imaging parameter for assessing a patient’s baseline frailty. Here, we analyzed whether TMT correlates with Traumatic brain injury (TBI) severity and whether it can be used to predict outcome(s) after TBI. Methods: We analyzed the radiological and clinical data sets of 193 patients with TBI who were admitted to our institution and correlated the radiological data with clinical outcomes after stratification for TMT. Results: Our analyses showed a significant association between high TMT and increased risk for intracranial hemorrhage (<i>p</i> = 0.0135) but improved mRS at 6 months (<i>p</i> = 0.001) as compared to patients with low TMT. Congruent with such findings, a lower TMT was associated with falls and reduced outcomes at 6 months (<i>p</i> < 0.0001 and <i>p</i> < 0.0001). Conclusion: High TMT was robustly associated with head trauma sequelae but was also associated with good clinical outcomes in TBI patients. These findings consolidate the significance of TMT as an objective marker of frailty in TBI patients; such measurements may ultimately be leveraged as prognostic indicators.https://www.mdpi.com/2077-0383/12/24/7625traumatic brain injury (TBI)frailtytemporal muscle thickness (TMT)sarcopeniaoutcomerisk factors |
| spellingShingle | Daniel Dubinski Sae-Yeon Won Jonas Meyer-Wilmes Svorad Trnovec Artem Rafaelian Bedjan Behmanesh Daniel Cantré Peter Baumgarten Nazife Dinc Juergen Konczalla Matthias Wittstock Joshua D. Bernstock Thomas M. Freiman Florian Gessler Frailty in Traumatic Brain Injury—The Significance of Temporal Muscle Thickness Journal of Clinical Medicine traumatic brain injury (TBI) frailty temporal muscle thickness (TMT) sarcopenia outcome risk factors |
| title | Frailty in Traumatic Brain Injury—The Significance of Temporal Muscle Thickness |
| title_full | Frailty in Traumatic Brain Injury—The Significance of Temporal Muscle Thickness |
| title_fullStr | Frailty in Traumatic Brain Injury—The Significance of Temporal Muscle Thickness |
| title_full_unstemmed | Frailty in Traumatic Brain Injury—The Significance of Temporal Muscle Thickness |
| title_short | Frailty in Traumatic Brain Injury—The Significance of Temporal Muscle Thickness |
| title_sort | frailty in traumatic brain injury the significance of temporal muscle thickness |
| topic | traumatic brain injury (TBI) frailty temporal muscle thickness (TMT) sarcopenia outcome risk factors |
| url | https://www.mdpi.com/2077-0383/12/24/7625 |
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