Bioelectric Dysregulation in Cancer Initiation, Promotion, and Progression
Cancer is primarily a disease of dysregulation – both at the genetic level and at the tissue organization level. One way that tissue organization is dysregulated is by changes in the bioelectric regulation of cell signaling pathways. At the basis of bioelectricity lies the cellular membrane potentia...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.846917/full |
| _version_ | 1818137798524272640 |
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| author | Maulee Sheth Leyla Esfandiari Leyla Esfandiari Leyla Esfandiari |
| author_facet | Maulee Sheth Leyla Esfandiari Leyla Esfandiari Leyla Esfandiari |
| author_sort | Maulee Sheth |
| collection | DOAJ |
| description | Cancer is primarily a disease of dysregulation – both at the genetic level and at the tissue organization level. One way that tissue organization is dysregulated is by changes in the bioelectric regulation of cell signaling pathways. At the basis of bioelectricity lies the cellular membrane potential or Vmem, an intrinsic property associated with any cell. The bioelectric state of cancer cells is different from that of healthy cells, causing a disruption in the cellular signaling pathways. This disruption or dysregulation affects all three processes of carcinogenesis – initiation, promotion, and progression. Another mechanism that facilitates the homeostasis of cell signaling pathways is the production of extracellular vesicles (EVs) by cells. EVs also play a role in carcinogenesis by mediating cellular communication within the tumor microenvironment (TME). Furthermore, the production and release of EVs is altered in cancer. To this end, the change in cell electrical state and in EV production are responsible for the bioelectric dysregulation which occurs during cancer. This paper reviews the bioelectric dysregulation associated with carcinogenesis, including the TME and metastasis. We also look at the major ion channels associated with cancer and current technologies and tools used to detect and manipulate bioelectric properties of cells. |
| first_indexed | 2024-12-11T10:02:02Z |
| format | Article |
| id | doaj.art-edbd6d44a4f340e585e9c8bc64145672 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-11T10:02:02Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-edbd6d44a4f340e585e9c8bc641456722022-12-22T01:12:07ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-03-011210.3389/fonc.2022.846917846917Bioelectric Dysregulation in Cancer Initiation, Promotion, and ProgressionMaulee Sheth0Leyla Esfandiari1Leyla Esfandiari2Leyla Esfandiari3Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH, United StatesDepartment of Biomedical Engineering, University of Cincinnati, Cincinnati, OH, United StatesDepartment of Electrical Engineering and Computer Science, University of Cincinnati, Cincinnati, OH, United StatesDepartment of Environmental and Public Health Sciences, University of Cincinnati, Cincinnati, OH, United StatesCancer is primarily a disease of dysregulation – both at the genetic level and at the tissue organization level. One way that tissue organization is dysregulated is by changes in the bioelectric regulation of cell signaling pathways. At the basis of bioelectricity lies the cellular membrane potential or Vmem, an intrinsic property associated with any cell. The bioelectric state of cancer cells is different from that of healthy cells, causing a disruption in the cellular signaling pathways. This disruption or dysregulation affects all three processes of carcinogenesis – initiation, promotion, and progression. Another mechanism that facilitates the homeostasis of cell signaling pathways is the production of extracellular vesicles (EVs) by cells. EVs also play a role in carcinogenesis by mediating cellular communication within the tumor microenvironment (TME). Furthermore, the production and release of EVs is altered in cancer. To this end, the change in cell electrical state and in EV production are responsible for the bioelectric dysregulation which occurs during cancer. This paper reviews the bioelectric dysregulation associated with carcinogenesis, including the TME and metastasis. We also look at the major ion channels associated with cancer and current technologies and tools used to detect and manipulate bioelectric properties of cells.https://www.frontiersin.org/articles/10.3389/fonc.2022.846917/fullbioelectricityextracellular vesiclestumor microenvironmentmembrane potentialcarcinogenesispiezo channels |
| spellingShingle | Maulee Sheth Leyla Esfandiari Leyla Esfandiari Leyla Esfandiari Bioelectric Dysregulation in Cancer Initiation, Promotion, and Progression Frontiers in Oncology bioelectricity extracellular vesicles tumor microenvironment membrane potential carcinogenesis piezo channels |
| title | Bioelectric Dysregulation in Cancer Initiation, Promotion, and Progression |
| title_full | Bioelectric Dysregulation in Cancer Initiation, Promotion, and Progression |
| title_fullStr | Bioelectric Dysregulation in Cancer Initiation, Promotion, and Progression |
| title_full_unstemmed | Bioelectric Dysregulation in Cancer Initiation, Promotion, and Progression |
| title_short | Bioelectric Dysregulation in Cancer Initiation, Promotion, and Progression |
| title_sort | bioelectric dysregulation in cancer initiation promotion and progression |
| topic | bioelectricity extracellular vesicles tumor microenvironment membrane potential carcinogenesis piezo channels |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.846917/full |
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