Plant Virus Nanoparticles Combat Cancer
Plant virus nanoparticles (PVNPs) have garnered considerable interest as a promising nanotechnology approach to combat cancer. Owing to their biocompatibility, stability, and adjustable surface functionality, PVNPs hold tremendous potential for both therapeutic and imaging applications. The versatil...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/11/8/1278 |
| _version_ | 1797583106648047616 |
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| author | Mehdi Shahgolzari Srividhya Venkataraman Anne Osano Paul Achile Akpa Kathleen Hefferon |
| author_facet | Mehdi Shahgolzari Srividhya Venkataraman Anne Osano Paul Achile Akpa Kathleen Hefferon |
| author_sort | Mehdi Shahgolzari |
| collection | DOAJ |
| description | Plant virus nanoparticles (PVNPs) have garnered considerable interest as a promising nanotechnology approach to combat cancer. Owing to their biocompatibility, stability, and adjustable surface functionality, PVNPs hold tremendous potential for both therapeutic and imaging applications. The versatility of PVNPs is evident from their ability to be tailored to transport a range of therapeutic agents, including chemotherapy drugs, siRNA, and immunomodulators, thereby facilitating targeted delivery to the tumor microenvironment (TME). Furthermore, PVNPs may be customized with targeting ligands to selectively bind to cancer cell receptors, reducing off-target effects. Additionally, PVNPs possess immunogenic properties and can be engineered to exhibit tumor-associated antigens, thereby stimulating anti-tumor immune responses. In conclusion, the potential of PVNPs as a versatile platform for fighting cancer is immense, and further research is required to fully explore their potential and translate them into clinical applications. |
| first_indexed | 2024-03-10T23:32:08Z |
| format | Article |
| id | doaj.art-edbe1c179bf54d3f9d3e2341c3671066 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T23:32:08Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-edbe1c179bf54d3f9d3e2341c36710662023-11-19T03:16:49ZengMDPI AGVaccines2076-393X2023-07-01118127810.3390/vaccines11081278Plant Virus Nanoparticles Combat CancerMehdi Shahgolzari0Srividhya Venkataraman1Anne Osano2Paul Achile Akpa3Kathleen Hefferon4Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz 5166616471, IranDepartment of Cell & Systems Biology, University of Toronto, Toronto, ON M5S 3B2, CanadaDepartment of Natural Sciences, Bowie State University, Bowie, MD 20715, USADepartment of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka 410001, Enugu State, NigeriaDepartment of Microbiology, Cornell University, Ithaca, NY 14850, USAPlant virus nanoparticles (PVNPs) have garnered considerable interest as a promising nanotechnology approach to combat cancer. Owing to their biocompatibility, stability, and adjustable surface functionality, PVNPs hold tremendous potential for both therapeutic and imaging applications. The versatility of PVNPs is evident from their ability to be tailored to transport a range of therapeutic agents, including chemotherapy drugs, siRNA, and immunomodulators, thereby facilitating targeted delivery to the tumor microenvironment (TME). Furthermore, PVNPs may be customized with targeting ligands to selectively bind to cancer cell receptors, reducing off-target effects. Additionally, PVNPs possess immunogenic properties and can be engineered to exhibit tumor-associated antigens, thereby stimulating anti-tumor immune responses. In conclusion, the potential of PVNPs as a versatile platform for fighting cancer is immense, and further research is required to fully explore their potential and translate them into clinical applications.https://www.mdpi.com/2076-393X/11/8/1278nanoparticlesplant virus-like particlesvaccinesdelivery |
| spellingShingle | Mehdi Shahgolzari Srividhya Venkataraman Anne Osano Paul Achile Akpa Kathleen Hefferon Plant Virus Nanoparticles Combat Cancer Vaccines nanoparticles plant virus-like particles vaccines delivery |
| title | Plant Virus Nanoparticles Combat Cancer |
| title_full | Plant Virus Nanoparticles Combat Cancer |
| title_fullStr | Plant Virus Nanoparticles Combat Cancer |
| title_full_unstemmed | Plant Virus Nanoparticles Combat Cancer |
| title_short | Plant Virus Nanoparticles Combat Cancer |
| title_sort | plant virus nanoparticles combat cancer |
| topic | nanoparticles plant virus-like particles vaccines delivery |
| url | https://www.mdpi.com/2076-393X/11/8/1278 |
| work_keys_str_mv | AT mehdishahgolzari plantvirusnanoparticlescombatcancer AT srividhyavenkataraman plantvirusnanoparticlescombatcancer AT anneosano plantvirusnanoparticlescombatcancer AT paulachileakpa plantvirusnanoparticlescombatcancer AT kathleenhefferon plantvirusnanoparticlescombatcancer |