Accelerating functional gene discovery in osteoarthritis
Osteoarthritis is a chronic, heritable disease with no available treatment. Here, the authors show that a validated, rapid-throughput joint phenotyping pipeline detects osteoarthritis in the mouse knee following surgical provocation, in aging and after single gene deletion or point mutation.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-01-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-20761-5 |
| _version_ | 1818851239944781824 |
|---|---|
| author | Natalie C. Butterfield Katherine F. Curry Julia Steinberg Hannah Dewhurst Davide Komla-Ebri Naila S. Mannan Anne-Tounsia Adoum Victoria D. Leitch John G. Logan Julian A. Waung Elena Ghirardello Lorraine Southam Scott E. Youlten J. Mark Wilkinson Elizabeth A. McAninch Valerie E. Vancollie Fiona Kussy Jacqueline K. White Christopher J. Lelliott David J. Adams Richard Jacques Antonio C. Bianco Alan Boyde Eleftheria Zeggini Peter I. Croucher Graham R. Williams J. H. Duncan Bassett |
| author_facet | Natalie C. Butterfield Katherine F. Curry Julia Steinberg Hannah Dewhurst Davide Komla-Ebri Naila S. Mannan Anne-Tounsia Adoum Victoria D. Leitch John G. Logan Julian A. Waung Elena Ghirardello Lorraine Southam Scott E. Youlten J. Mark Wilkinson Elizabeth A. McAninch Valerie E. Vancollie Fiona Kussy Jacqueline K. White Christopher J. Lelliott David J. Adams Richard Jacques Antonio C. Bianco Alan Boyde Eleftheria Zeggini Peter I. Croucher Graham R. Williams J. H. Duncan Bassett |
| author_sort | Natalie C. Butterfield |
| collection | DOAJ |
| description | Osteoarthritis is a chronic, heritable disease with no available treatment. Here, the authors show that a validated, rapid-throughput joint phenotyping pipeline detects osteoarthritis in the mouse knee following surgical provocation, in aging and after single gene deletion or point mutation. |
| first_indexed | 2024-12-19T07:01:52Z |
| format | Article |
| id | doaj.art-edbe1f565dfb4cb59b5b96ecd707f7bc |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T07:01:52Z |
| publishDate | 2021-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-edbe1f565dfb4cb59b5b96ecd707f7bc2022-12-21T20:31:23ZengNature PortfolioNature Communications2041-17232021-01-0112111810.1038/s41467-020-20761-5Accelerating functional gene discovery in osteoarthritisNatalie C. Butterfield0Katherine F. Curry1Julia Steinberg2Hannah Dewhurst3Davide Komla-Ebri4Naila S. Mannan5Anne-Tounsia Adoum6Victoria D. Leitch7John G. Logan8Julian A. Waung9Elena Ghirardello10Lorraine Southam11Scott E. Youlten12J. Mark Wilkinson13Elizabeth A. McAninch14Valerie E. Vancollie15Fiona Kussy16Jacqueline K. White17Christopher J. Lelliott18David J. Adams19Richard Jacques20Antonio C. Bianco21Alan Boyde22Eleftheria Zeggini23Peter I. Croucher24Graham R. Williams25J. H. Duncan Bassett26Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College LondonMolecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College LondonInstitute of Translational Genomics, Helmholtz Zentrum München – German Research Center for Environmental HealthMolecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College LondonMolecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College LondonMolecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College LondonMolecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College LondonMolecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College LondonMolecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College LondonMolecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College LondonMolecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College LondonInstitute of Translational Genomics, Helmholtz Zentrum München – German Research Center for Environmental HealthThe Garvan Institute of Medical Research and St. Vincent’s Clinical School, University of New South Wales MedicineDepartment of Oncology and Metabolism, University of SheffieldDivision of Endocrinology and Metabolism, Rush University Medical CenterWellcome Trust Sanger InstituteWellcome Trust Sanger InstituteWellcome Trust Sanger InstituteWellcome Trust Sanger InstituteWellcome Trust Sanger InstituteSchool of Health and Related Research (ScHARR), University of SheffieldSection of Adult and Pediatric Endocrinology, Diabetes & Metabolism, Department of Medicine, University of ChicagoDental Physical Sciences, Queen Mary University of London, Mile End RoadInstitute of Translational Genomics, Helmholtz Zentrum München – German Research Center for Environmental HealthThe Garvan Institute of Medical Research and St. Vincent’s Clinical School, University of New South Wales MedicineMolecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College LondonMolecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College LondonOsteoarthritis is a chronic, heritable disease with no available treatment. Here, the authors show that a validated, rapid-throughput joint phenotyping pipeline detects osteoarthritis in the mouse knee following surgical provocation, in aging and after single gene deletion or point mutation.https://doi.org/10.1038/s41467-020-20761-5 |
| spellingShingle | Natalie C. Butterfield Katherine F. Curry Julia Steinberg Hannah Dewhurst Davide Komla-Ebri Naila S. Mannan Anne-Tounsia Adoum Victoria D. Leitch John G. Logan Julian A. Waung Elena Ghirardello Lorraine Southam Scott E. Youlten J. Mark Wilkinson Elizabeth A. McAninch Valerie E. Vancollie Fiona Kussy Jacqueline K. White Christopher J. Lelliott David J. Adams Richard Jacques Antonio C. Bianco Alan Boyde Eleftheria Zeggini Peter I. Croucher Graham R. Williams J. H. Duncan Bassett Accelerating functional gene discovery in osteoarthritis Nature Communications |
| title | Accelerating functional gene discovery in osteoarthritis |
| title_full | Accelerating functional gene discovery in osteoarthritis |
| title_fullStr | Accelerating functional gene discovery in osteoarthritis |
| title_full_unstemmed | Accelerating functional gene discovery in osteoarthritis |
| title_short | Accelerating functional gene discovery in osteoarthritis |
| title_sort | accelerating functional gene discovery in osteoarthritis |
| url | https://doi.org/10.1038/s41467-020-20761-5 |
| work_keys_str_mv | AT nataliecbutterfield acceleratingfunctionalgenediscoveryinosteoarthritis AT katherinefcurry acceleratingfunctionalgenediscoveryinosteoarthritis AT juliasteinberg acceleratingfunctionalgenediscoveryinosteoarthritis AT hannahdewhurst acceleratingfunctionalgenediscoveryinosteoarthritis AT davidekomlaebri acceleratingfunctionalgenediscoveryinosteoarthritis AT nailasmannan acceleratingfunctionalgenediscoveryinosteoarthritis AT annetounsiaadoum acceleratingfunctionalgenediscoveryinosteoarthritis AT victoriadleitch acceleratingfunctionalgenediscoveryinosteoarthritis AT johnglogan acceleratingfunctionalgenediscoveryinosteoarthritis AT julianawaung acceleratingfunctionalgenediscoveryinosteoarthritis AT elenaghirardello acceleratingfunctionalgenediscoveryinosteoarthritis AT lorrainesoutham acceleratingfunctionalgenediscoveryinosteoarthritis AT scotteyoulten acceleratingfunctionalgenediscoveryinosteoarthritis AT jmarkwilkinson acceleratingfunctionalgenediscoveryinosteoarthritis AT elizabethamcaninch acceleratingfunctionalgenediscoveryinosteoarthritis AT valerieevancollie acceleratingfunctionalgenediscoveryinosteoarthritis AT fionakussy acceleratingfunctionalgenediscoveryinosteoarthritis AT jacquelinekwhite acceleratingfunctionalgenediscoveryinosteoarthritis AT christopherjlelliott acceleratingfunctionalgenediscoveryinosteoarthritis AT davidjadams acceleratingfunctionalgenediscoveryinosteoarthritis AT richardjacques acceleratingfunctionalgenediscoveryinosteoarthritis AT antoniocbianco acceleratingfunctionalgenediscoveryinosteoarthritis AT alanboyde acceleratingfunctionalgenediscoveryinosteoarthritis AT eleftheriazeggini acceleratingfunctionalgenediscoveryinosteoarthritis AT petericroucher acceleratingfunctionalgenediscoveryinosteoarthritis AT grahamrwilliams acceleratingfunctionalgenediscoveryinosteoarthritis AT jhduncanbassett acceleratingfunctionalgenediscoveryinosteoarthritis |