Quantifying Radiosensitization of PSMA-Targeted Gold Nanoparticles on Prostate Cancer Cells at Megavoltage Radiation Energies by Monte Carlo Simulation and Local Effect Model

Quantifying Radiosensitization of PSMA-Targeted Gold Nanoparticles on Prostate Cancer Cells at Megavoltage Radiation Energies by Monte Carlo Simulation and Local Effect Model

Active targeting gold nanoparticles (AuNPs) are a very promising avenue for cancer treatment with many publications on AuNP mediated radiosensitization at kilovoltage (kV) photon energies. However, uncertainty on the effectiveness of AuNPs under clinically relevant megavoltage (MV) radiation energie...

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Bibliographic Details
Main Authors: Ryder M. Schmidt, Daiki Hara, Jorge D. Vega, Marwan B. Abuhaija, Wensi Tao, Nesrin Dogan, Alan Pollack, John C. Ford, Junwei Shi
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Pharmaceutics
Subjects:
gold nanoparticle
nanoparticle enhanced radiation therapy
Monte Carlo
local effect model
dose enhancement ratio
sensitization enhancement ratio
Online Access:https://www.mdpi.com/1999-4923/14/10/2205

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