Non‐invasive evaluation of new‐onset atrial fibrillation after cardiac surgery: a protocol for the BigMap study
Abstract Aims New‐onset atrial fibrillation (NOAF) is the most common complication after cardiac surgery, occurring in 25–50% of patients. It is associated with post‐operative stroke, increased mortality, prolonged hospital length of stay, and higher treatment costs. Previous small observational stu...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-08-01
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| Series: | ESC Heart Failure |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ehf2.13902 |
| _version_ | 1818473901239304192 |
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| author | Constantin Mork Simon Adrian Amacher Brigitta Gahl Luca Koechlin Jules Miazza Thibault Schaeffer Lena Schmuelling Jens Bremerich Denis Berdajs Nadine Cueni Michael Kühne Christian Mueller Stefan Osswald Oliver Reuthebuch Ulrich Schurr Christian Sticherling Andrea Kopp Lugli Stephan Marsch Hans Pargger Martin Siegemund Friedrich Eckstein Alexa Hollinger David Santer |
| author_facet | Constantin Mork Simon Adrian Amacher Brigitta Gahl Luca Koechlin Jules Miazza Thibault Schaeffer Lena Schmuelling Jens Bremerich Denis Berdajs Nadine Cueni Michael Kühne Christian Mueller Stefan Osswald Oliver Reuthebuch Ulrich Schurr Christian Sticherling Andrea Kopp Lugli Stephan Marsch Hans Pargger Martin Siegemund Friedrich Eckstein Alexa Hollinger David Santer |
| author_sort | Constantin Mork |
| collection | DOAJ |
| description | Abstract Aims New‐onset atrial fibrillation (NOAF) is the most common complication after cardiac surgery, occurring in 25–50% of patients. It is associated with post‐operative stroke, increased mortality, prolonged hospital length of stay, and higher treatment costs. Previous small observational studies have identified the left atrium as a source of the electrical rotors and foci maintaining NOAF, but confirmation by a large prospective clinical study is still missing. The aim of the proposed study is to investigate whether the source of NOAF lies in the left atrium. The correct identification of NOAF‐maintaining structures in cardiac surgical patients might offer potential therapeutic targets for prophylactic perioperative ablation strategies. Methods and results This is a prospective single‐centre observational study of patients developing NOAF after cardiac surgery. The primary outcome is the description of NOAF‐maintaining structures within the atria. Key secondary outcomes include overall mortality, intensive care unit length of stay, hospital–ventilator‐free days, and proportion of persistent NOAF. In NOAF patients, the non‐invasive electrophysiological mapping will be conducted using a 252‐electrode electrocardiogram vest. After mapping, a low‐dose computed tomography scan of the chest will be performed to integrate the electrophysiological mapping results into a 3D picture of the heart. The study will include approximately 570 patients, of whom 30% (n = 170) are expected to develop NOAF. Sample size calculation revealed that 157 NOAF patients are necessary to assess the primary outcome. Patients will be tracked for a total of 5 years. Conclusions This is the largest prospective study to date describing the electrophysiological mechanisms of NOAF using non‐invasive mapping. |
| first_indexed | 2024-04-14T04:30:07Z |
| format | Article |
| id | doaj.art-edbe725b7e9f473bb7f38145633cf0c6 |
| institution | Directory Open Access Journal |
| issn | 2055-5822 |
| language | English |
| last_indexed | 2024-04-14T04:30:07Z |
| publishDate | 2022-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | ESC Heart Failure |
| spelling | doaj.art-edbe725b7e9f473bb7f38145633cf0c62022-12-22T02:12:08ZengWileyESC Heart Failure2055-58222022-08-01942703271210.1002/ehf2.13902Non‐invasive evaluation of new‐onset atrial fibrillation after cardiac surgery: a protocol for the BigMap studyConstantin Mork0Simon Adrian Amacher1Brigitta Gahl2Luca Koechlin3Jules Miazza4Thibault Schaeffer5Lena Schmuelling6Jens Bremerich7Denis Berdajs8Nadine Cueni9Michael Kühne10Christian Mueller11Stefan Osswald12Oliver Reuthebuch13Ulrich Schurr14Christian Sticherling15Andrea Kopp Lugli16Stephan Marsch17Hans Pargger18Martin Siegemund19Friedrich Eckstein20Alexa Hollinger21David Santer22Department of Cardiac Surgery University Hospital Basel Spitalstrasse 21 Basel 4031 SwitzerlandIntensive Care Unit University Hospital Basel Basel SwitzerlandDepartment of Cardiac Surgery University Hospital Basel Spitalstrasse 21 Basel 4031 SwitzerlandDepartment of Cardiac Surgery University Hospital Basel Spitalstrasse 21 Basel 4031 SwitzerlandDepartment of Cardiac Surgery University Hospital Basel Spitalstrasse 21 Basel 4031 SwitzerlandDepartment of Cardiac Surgery University Hospital Basel Spitalstrasse 21 Basel 4031 SwitzerlandDepartment of Radiology University Hospital Basel Basel SwitzerlandDepartment of Radiology University Hospital Basel Basel SwitzerlandDepartment of Cardiac Surgery University Hospital Basel Spitalstrasse 21 Basel 4031 SwitzerlandIntensive Care Unit University Hospital Basel Basel SwitzerlandCardiovascular Research Institute (CRIB) and Department of Cardiology University Hospital Basel, University of Basel Basel SwitzerlandCardiovascular Research Institute (CRIB) and Department of Cardiology University Hospital Basel, University of Basel Basel SwitzerlandCardiovascular Research Institute (CRIB) and Department of Cardiology University Hospital Basel, University of Basel Basel SwitzerlandDepartment of Cardiac Surgery University Hospital Basel Spitalstrasse 21 Basel 4031 SwitzerlandDepartment of Cardiac Surgery University Hospital Basel Spitalstrasse 21 Basel 4031 SwitzerlandCardiovascular Research Institute (CRIB) and Department of Cardiology University Hospital Basel, University of Basel Basel SwitzerlandMedical Faculty of the University of Basel Basel SwitzerlandIntensive Care Unit University Hospital Basel Basel SwitzerlandIntensive Care Unit University Hospital Basel Basel SwitzerlandIntensive Care Unit University Hospital Basel Basel SwitzerlandDepartment of Cardiac Surgery University Hospital Basel Spitalstrasse 21 Basel 4031 SwitzerlandIntensive Care Unit University Hospital Basel Basel SwitzerlandDepartment of Cardiac Surgery University Hospital Basel Spitalstrasse 21 Basel 4031 SwitzerlandAbstract Aims New‐onset atrial fibrillation (NOAF) is the most common complication after cardiac surgery, occurring in 25–50% of patients. It is associated with post‐operative stroke, increased mortality, prolonged hospital length of stay, and higher treatment costs. Previous small observational studies have identified the left atrium as a source of the electrical rotors and foci maintaining NOAF, but confirmation by a large prospective clinical study is still missing. The aim of the proposed study is to investigate whether the source of NOAF lies in the left atrium. The correct identification of NOAF‐maintaining structures in cardiac surgical patients might offer potential therapeutic targets for prophylactic perioperative ablation strategies. Methods and results This is a prospective single‐centre observational study of patients developing NOAF after cardiac surgery. The primary outcome is the description of NOAF‐maintaining structures within the atria. Key secondary outcomes include overall mortality, intensive care unit length of stay, hospital–ventilator‐free days, and proportion of persistent NOAF. In NOAF patients, the non‐invasive electrophysiological mapping will be conducted using a 252‐electrode electrocardiogram vest. After mapping, a low‐dose computed tomography scan of the chest will be performed to integrate the electrophysiological mapping results into a 3D picture of the heart. The study will include approximately 570 patients, of whom 30% (n = 170) are expected to develop NOAF. Sample size calculation revealed that 157 NOAF patients are necessary to assess the primary outcome. Patients will be tracked for a total of 5 years. Conclusions This is the largest prospective study to date describing the electrophysiological mechanisms of NOAF using non‐invasive mapping.https://doi.org/10.1002/ehf2.13902Cardiac surgeryNew‐onset atrial fibrillationNon‐invasive cardiac mappingCardiac surgical critical care |
| spellingShingle | Constantin Mork Simon Adrian Amacher Brigitta Gahl Luca Koechlin Jules Miazza Thibault Schaeffer Lena Schmuelling Jens Bremerich Denis Berdajs Nadine Cueni Michael Kühne Christian Mueller Stefan Osswald Oliver Reuthebuch Ulrich Schurr Christian Sticherling Andrea Kopp Lugli Stephan Marsch Hans Pargger Martin Siegemund Friedrich Eckstein Alexa Hollinger David Santer Non‐invasive evaluation of new‐onset atrial fibrillation after cardiac surgery: a protocol for the BigMap study ESC Heart Failure Cardiac surgery New‐onset atrial fibrillation Non‐invasive cardiac mapping Cardiac surgical critical care |
| title | Non‐invasive evaluation of new‐onset atrial fibrillation after cardiac surgery: a protocol for the BigMap study |
| title_full | Non‐invasive evaluation of new‐onset atrial fibrillation after cardiac surgery: a protocol for the BigMap study |
| title_fullStr | Non‐invasive evaluation of new‐onset atrial fibrillation after cardiac surgery: a protocol for the BigMap study |
| title_full_unstemmed | Non‐invasive evaluation of new‐onset atrial fibrillation after cardiac surgery: a protocol for the BigMap study |
| title_short | Non‐invasive evaluation of new‐onset atrial fibrillation after cardiac surgery: a protocol for the BigMap study |
| title_sort | non invasive evaluation of new onset atrial fibrillation after cardiac surgery a protocol for the bigmap study |
| topic | Cardiac surgery New‐onset atrial fibrillation Non‐invasive cardiac mapping Cardiac surgical critical care |
| url | https://doi.org/10.1002/ehf2.13902 |
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