Prognostic model of rapid hepatic fibrosis progression in men with chronic hepatitis C

The aim of the research was to determine clinical and genetic predictors and to create a prognostic model for the rapid hepatic fibrosis progression in men with chronic hepatitis C. Materials and methods. А cross-sectional study which included 111 male patients with chronic hepatitis C was conduc...

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Main Authors: T. I. Koval, L. M. Syzova, H. M. Dubynska, N. O. Pryimenko, S. S. Rudenko
Format: Article
Language:English
Published: Zaporozhye State Medical University 2019-05-01
Series:Patologìâ
Subjects:
Online Access:http://pat.zsmu.edu.ua/article/view/166214/167093
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author T. I. Koval
L. M. Syzova
H. M. Dubynska
N. O. Pryimenko
S. S. Rudenko
author_facet T. I. Koval
L. M. Syzova
H. M. Dubynska
N. O. Pryimenko
S. S. Rudenko
author_sort T. I. Koval
collection DOAJ
description The aim of the research was to determine clinical and genetic predictors and to create a prognostic model for the rapid hepatic fibrosis progression in men with chronic hepatitis C. Materials and methods. А cross-sectional study which included 111 male patients with chronic hepatitis C was conducted. The patient examination program included: assessment of complaints and anamnestic data, physical examination, complete blood count, biochemical test, the stages of hepatic fibrosis according to METAVIR аnd genetic studies (detecting carriers alleles 11Gln or 11Leu of TLR7 gene in the genome of the examined men). Results. It was determined that informative predictors of rapid hepatic fibrosis progression in men with chronic hepatitis C are: ethanol use in a dose of more than 40 g/day (ОR = 2.40, P = 0.042), presence of chronic cholecystitis in past history (ОR = 2.94, P = 0.013), ALT level above 3 upper limit of normal (ОR = 2.49, P = 0.031), the levels of AST, GGT exceeding upper limit of normal (ОR = 6.94, P < 0.001 and ОR = 4.02, P = 0.001 respectively), hyperbilirubinemia (ОR = 3.13, P = 0.010) and carrier state of allele 11Gln of TLR7 gene in the genome (ОR = 3.62, P = 0.036). In order to optimize the prognosis of rapid hepatic fibrosis progression in men with chronic hepatitis C a model that demonstrated statistical significance (χ² = 44.73, P < 0.001) and high operational characteristics (sensitivity – 76.8 %, specificity – 74.5 %, the total number of correct predictions – 75.7 %, AUC of the ROC-curve – 0.828), which indicates the feasibility of its practical use, was proposed. Conclusions. An effective clinical and genetic prognostic model has been created and allows us to predict the probability of rapid hepatic fibrosis progression in men with chronic hepatitis C with high accuracy and to form a group of patients who need high priority antiviral therapy.
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spelling doaj.art-edbeed8637e1470db95cec4a490706312022-12-21T23:18:27ZengZaporozhye State Medical UniversityPatologìâ2306-80272310-12372019-05-01161333810.14739/2310-1237.2019.1.166214Prognostic model of rapid hepatic fibrosis progression in men with chronic hepatitis CT. I. KovalL. M. SyzovaH. M. DubynskaN. O. PryimenkoS. S. RudenkoThe aim of the research was to determine clinical and genetic predictors and to create a prognostic model for the rapid hepatic fibrosis progression in men with chronic hepatitis C. Materials and methods. А cross-sectional study which included 111 male patients with chronic hepatitis C was conducted. The patient examination program included: assessment of complaints and anamnestic data, physical examination, complete blood count, biochemical test, the stages of hepatic fibrosis according to METAVIR аnd genetic studies (detecting carriers alleles 11Gln or 11Leu of TLR7 gene in the genome of the examined men). Results. It was determined that informative predictors of rapid hepatic fibrosis progression in men with chronic hepatitis C are: ethanol use in a dose of more than 40 g/day (ОR = 2.40, P = 0.042), presence of chronic cholecystitis in past history (ОR = 2.94, P = 0.013), ALT level above 3 upper limit of normal (ОR = 2.49, P = 0.031), the levels of AST, GGT exceeding upper limit of normal (ОR = 6.94, P < 0.001 and ОR = 4.02, P = 0.001 respectively), hyperbilirubinemia (ОR = 3.13, P = 0.010) and carrier state of allele 11Gln of TLR7 gene in the genome (ОR = 3.62, P = 0.036). In order to optimize the prognosis of rapid hepatic fibrosis progression in men with chronic hepatitis C a model that demonstrated statistical significance (χ² = 44.73, P < 0.001) and high operational characteristics (sensitivity – 76.8 %, specificity – 74.5 %, the total number of correct predictions – 75.7 %, AUC of the ROC-curve – 0.828), which indicates the feasibility of its practical use, was proposed. Conclusions. An effective clinical and genetic prognostic model has been created and allows us to predict the probability of rapid hepatic fibrosis progression in men with chronic hepatitis C with high accuracy and to form a group of patients who need high priority antiviral therapy.http://pat.zsmu.edu.ua/article/view/166214/167093chronic hepatitis Chepatic fibrosismenprognosisTLR7 gene
spellingShingle T. I. Koval
L. M. Syzova
H. M. Dubynska
N. O. Pryimenko
S. S. Rudenko
Prognostic model of rapid hepatic fibrosis progression in men with chronic hepatitis C
Patologìâ
chronic hepatitis C
hepatic fibrosis
men
prognosis
TLR7 gene
title Prognostic model of rapid hepatic fibrosis progression in men with chronic hepatitis C
title_full Prognostic model of rapid hepatic fibrosis progression in men with chronic hepatitis C
title_fullStr Prognostic model of rapid hepatic fibrosis progression in men with chronic hepatitis C
title_full_unstemmed Prognostic model of rapid hepatic fibrosis progression in men with chronic hepatitis C
title_short Prognostic model of rapid hepatic fibrosis progression in men with chronic hepatitis C
title_sort prognostic model of rapid hepatic fibrosis progression in men with chronic hepatitis c
topic chronic hepatitis C
hepatic fibrosis
men
prognosis
TLR7 gene
url http://pat.zsmu.edu.ua/article/view/166214/167093
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AT nopryimenko prognosticmodelofrapidhepaticfibrosisprogressioninmenwithchronichepatitisc
AT ssrudenko prognosticmodelofrapidhepaticfibrosisprogressioninmenwithchronichepatitisc