A Facile Synthesis of Fully Protected meso-Diaminopimelic Acid (DAP) and Its Application to the Preparation of Lipophilic N-Acyl iE-DAP

A Facile Synthesis of Fully Protected meso-Diaminopimelic Acid (DAP) and Its Application to the Preparation of Lipophilic N-Acyl iE-DAP

Synthesis of beneficial protected meso-DAP 9 by cross metathesis of the Garner aldehyde-derived vinyl glycine 1b with protected allyl glycine 2 in the presence of Grubbs second-generation catalyst was performed. Preparation of lipophilic N-acyl iE-DAP as potent agonists of NOD 1-mediated immune resp...

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Bibliographic Details
Main Authors: Hiroki Takahata, Hideaki Wakamatsu, Yuichi Yoshimura, Yukako Saito
Format: Article
Language:English
Published: MDPI AG 2013-01-01
Series:Molecules
Subjects:
protected meso-diaminopimelic acid
N-acyl iE-DAP
cross metathesis
Online Access:http://www.mdpi.com/1420-3049/18/1/1162

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