Comorbidity in incident osteoarthritis cases and matched controls using electronic health record data
Abstract Background Comorbidities are common in patients with osteoarthritis (OA). This study aimed to determine the association of a wide range of previously diagnosed comorbidities in adults with newly diagnosed OA compared with matched controls without OA. Methods A case–control study was conduct...
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BMC
2023-07-01
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| Series: | Arthritis Research & Therapy |
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| Online Access: | https://doi.org/10.1186/s13075-023-03086-8 |
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| author | Anne Kamps Jos Runhaar Maria A. J. de Ridder Marcel de Wilde Johan van der Lei Weiya Zhang Daniel Prieto-Alhambra Martin Englund Evelien I. T. de Schepper Sita M. A. Bierma-Zeinstra |
| author_facet | Anne Kamps Jos Runhaar Maria A. J. de Ridder Marcel de Wilde Johan van der Lei Weiya Zhang Daniel Prieto-Alhambra Martin Englund Evelien I. T. de Schepper Sita M. A. Bierma-Zeinstra |
| author_sort | Anne Kamps |
| collection | DOAJ |
| description | Abstract Background Comorbidities are common in patients with osteoarthritis (OA). This study aimed to determine the association of a wide range of previously diagnosed comorbidities in adults with newly diagnosed OA compared with matched controls without OA. Methods A case–control study was conducted. The data were derived from an electronic health record database that contains the medical records of patients from general practices throughout the Netherlands. Incident OA cases were defined as patients with one or more diagnostic codes recorded in their medical records that correspond to knee, hip, or other/peripheral OA. Additionally, the first OA code had to be recorded between January 1, 2006, and December 31, 2019. The date of cases’ first OA diagnosis was defined as the index date. Cases were matched (by age, sex, and general practice) to up to 4 controls without a recorded OA diagnosis. Odds ratios were derived for each 58 comorbidities separately by dividing the comorbidity prevalence of cases by that of their matched controls at the index date. Results 80,099 incident OA patients were identified of whom 79,937 (99.8%) were successfully matched with 318,206 controls. OA cases had higher odds for 42 of the 58 studied comorbidities compared with matched controls. Musculoskeletal diseases and obesity showed large associations with incident OA. Conclusions Most of the comorbidities under study had higher odds in patients with incident OA at the index date. While previously known associations were confirmed in this study, some associations were not described earlier. |
| first_indexed | 2024-03-13T00:41:09Z |
| format | Article |
| id | doaj.art-edc0248d60184735b2a51cdfaddc87f1 |
| institution | Directory Open Access Journal |
| issn | 1478-6362 |
| language | English |
| last_indexed | 2024-03-13T00:41:09Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Arthritis Research & Therapy |
| spelling | doaj.art-edc0248d60184735b2a51cdfaddc87f12023-07-09T11:20:22ZengBMCArthritis Research & Therapy1478-63622023-07-0125111010.1186/s13075-023-03086-8Comorbidity in incident osteoarthritis cases and matched controls using electronic health record dataAnne Kamps0Jos Runhaar1Maria A. J. de Ridder2Marcel de Wilde3Johan van der Lei4Weiya Zhang5Daniel Prieto-Alhambra6Martin Englund7Evelien I. T. de Schepper8Sita M. A. Bierma-Zeinstra9Department of General Practice, Erasmus MCDepartment of General Practice, Erasmus MCDepartment of Medical Informatics, Erasmus MCDepartment of Medical Informatics, Erasmus MCDepartment of Medical Informatics, Erasmus MCSchool of Medicine, Faculty of Medicine & Health Sciences, Queen’s Medical Centre, University of NottinghamDepartment of Medical Informatics, Erasmus MCClinical Epidemiology Unit, Orthopaedics, Department of Clinical Sciences, Lund University, WigerthusetDepartment of General Practice, Erasmus MCDepartment of General Practice, Erasmus MCAbstract Background Comorbidities are common in patients with osteoarthritis (OA). This study aimed to determine the association of a wide range of previously diagnosed comorbidities in adults with newly diagnosed OA compared with matched controls without OA. Methods A case–control study was conducted. The data were derived from an electronic health record database that contains the medical records of patients from general practices throughout the Netherlands. Incident OA cases were defined as patients with one or more diagnostic codes recorded in their medical records that correspond to knee, hip, or other/peripheral OA. Additionally, the first OA code had to be recorded between January 1, 2006, and December 31, 2019. The date of cases’ first OA diagnosis was defined as the index date. Cases were matched (by age, sex, and general practice) to up to 4 controls without a recorded OA diagnosis. Odds ratios were derived for each 58 comorbidities separately by dividing the comorbidity prevalence of cases by that of their matched controls at the index date. Results 80,099 incident OA patients were identified of whom 79,937 (99.8%) were successfully matched with 318,206 controls. OA cases had higher odds for 42 of the 58 studied comorbidities compared with matched controls. Musculoskeletal diseases and obesity showed large associations with incident OA. Conclusions Most of the comorbidities under study had higher odds in patients with incident OA at the index date. While previously known associations were confirmed in this study, some associations were not described earlier.https://doi.org/10.1186/s13075-023-03086-8OsteoarthritisComorbidityPrimary CareEpidemiology |
| spellingShingle | Anne Kamps Jos Runhaar Maria A. J. de Ridder Marcel de Wilde Johan van der Lei Weiya Zhang Daniel Prieto-Alhambra Martin Englund Evelien I. T. de Schepper Sita M. A. Bierma-Zeinstra Comorbidity in incident osteoarthritis cases and matched controls using electronic health record data Arthritis Research & Therapy Osteoarthritis Comorbidity Primary Care Epidemiology |
| title | Comorbidity in incident osteoarthritis cases and matched controls using electronic health record data |
| title_full | Comorbidity in incident osteoarthritis cases and matched controls using electronic health record data |
| title_fullStr | Comorbidity in incident osteoarthritis cases and matched controls using electronic health record data |
| title_full_unstemmed | Comorbidity in incident osteoarthritis cases and matched controls using electronic health record data |
| title_short | Comorbidity in incident osteoarthritis cases and matched controls using electronic health record data |
| title_sort | comorbidity in incident osteoarthritis cases and matched controls using electronic health record data |
| topic | Osteoarthritis Comorbidity Primary Care Epidemiology |
| url | https://doi.org/10.1186/s13075-023-03086-8 |
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