Revitalize splenic functions. Following a splenectomy for trauma, a small amount of splenic autotransplantation was performed
Abstract Introduction The spleen is a responsible significant part of the immune system; after Splenectomy following trauma, the immune system changes; splenic autotransplantation can preserve the immune system after trauma and Splenectomy. Background Patients can be protected from immune dysfunctio...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-08-01
|
| Series: | BMC Surgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12893-023-02126-z |
| _version_ | 1797454119194066944 |
|---|---|
| author | Hassan A. Saad Rasha S Elsayed Mohamed Riad Ahmed K. El-Taher Mohamed E Eraky Ashraf Abdelmonem |
| author_facet | Hassan A. Saad Rasha S Elsayed Mohamed Riad Ahmed K. El-Taher Mohamed E Eraky Ashraf Abdelmonem |
| author_sort | Hassan A. Saad |
| collection | DOAJ |
| description | Abstract Introduction The spleen is a responsible significant part of the immune system; after Splenectomy following trauma, the immune system changes; splenic autotransplantation can preserve the immune system after trauma and Splenectomy. Background Patients can be protected from immune dysfunction by autotransplanting splenic tissues after splenectomy following trauma because their immune systems and spleens are changed. Patients can gain their immune function after splenic autotransplantation. Methods Patient classification methods are into three categories, Group A, 6 cases with auto-translation; Group B, 6 cases without transplantation; Group C, seven regular people serving as the control. Aim of work The aim of the work is not to compare outcome methods or compare types of autotransplantation; This work aims to document postoperative radiological, immunological, clinical, and hematological investigations. We concentrated on the results of investigations more than the types of operation or approach or types of autotransplantation. Results We showed that, after comparing each group with normal individuals subjects, patients who did not undergo autotransplantation had significantly higher platelet counts, a more significant percentage of micronucleated reticulocytes, increased levels of naive B lymphocytes, changes in class-switched memory and class-unswitched memory B cells, and higher levels of PD1 on CD8 + T lymphocytes. Nevertheless, neither splenic autotransplant patients nor the average general population showed any appreciable variations in any of the parameters. Conclusions Spleen’s activities with adequate hemocatheter activity and recovery of the immunological deficit after splenic autotransplantation. |
| first_indexed | 2024-03-09T15:32:39Z |
| format | Article |
| id | doaj.art-edc279ca1e42401591d97e2941152223 |
| institution | Directory Open Access Journal |
| issn | 1471-2482 |
| language | English |
| last_indexed | 2024-03-09T15:32:39Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Surgery |
| spelling | doaj.art-edc279ca1e42401591d97e29411522232023-11-26T12:11:49ZengBMCBMC Surgery1471-24822023-08-012311810.1186/s12893-023-02126-zRevitalize splenic functions. Following a splenectomy for trauma, a small amount of splenic autotransplantation was performedHassan A. Saad0Rasha S Elsayed1Mohamed Riad2Ahmed K. El-Taher3Mohamed E Eraky4Ashraf Abdelmonem5Surgical Department, Faculty of Medicine, Zagazig UniversitySurgical Department, Faculty of Medicine, Zagazig UniversitySurgical Department, Faculty of Medicine, Zagazig UniversitySurgical Department, Faculty of Medicine, Zagazig UniversitySurgical Department, Faculty of Medicine, Zagazig UniversitySurgical Department, Faculty of Medicine, Zagazig UniversityAbstract Introduction The spleen is a responsible significant part of the immune system; after Splenectomy following trauma, the immune system changes; splenic autotransplantation can preserve the immune system after trauma and Splenectomy. Background Patients can be protected from immune dysfunction by autotransplanting splenic tissues after splenectomy following trauma because their immune systems and spleens are changed. Patients can gain their immune function after splenic autotransplantation. Methods Patient classification methods are into three categories, Group A, 6 cases with auto-translation; Group B, 6 cases without transplantation; Group C, seven regular people serving as the control. Aim of work The aim of the work is not to compare outcome methods or compare types of autotransplantation; This work aims to document postoperative radiological, immunological, clinical, and hematological investigations. We concentrated on the results of investigations more than the types of operation or approach or types of autotransplantation. Results We showed that, after comparing each group with normal individuals subjects, patients who did not undergo autotransplantation had significantly higher platelet counts, a more significant percentage of micronucleated reticulocytes, increased levels of naive B lymphocytes, changes in class-switched memory and class-unswitched memory B cells, and higher levels of PD1 on CD8 + T lymphocytes. Nevertheless, neither splenic autotransplant patients nor the average general population showed any appreciable variations in any of the parameters. Conclusions Spleen’s activities with adequate hemocatheter activity and recovery of the immunological deficit after splenic autotransplantation.https://doi.org/10.1186/s12893-023-02126-zAutotransplantationSplenectomyTraumaSplenic functions |
| spellingShingle | Hassan A. Saad Rasha S Elsayed Mohamed Riad Ahmed K. El-Taher Mohamed E Eraky Ashraf Abdelmonem Revitalize splenic functions. Following a splenectomy for trauma, a small amount of splenic autotransplantation was performed BMC Surgery Autotransplantation Splenectomy Trauma Splenic functions |
| title | Revitalize splenic functions. Following a splenectomy for trauma, a small amount of splenic autotransplantation was performed |
| title_full | Revitalize splenic functions. Following a splenectomy for trauma, a small amount of splenic autotransplantation was performed |
| title_fullStr | Revitalize splenic functions. Following a splenectomy for trauma, a small amount of splenic autotransplantation was performed |
| title_full_unstemmed | Revitalize splenic functions. Following a splenectomy for trauma, a small amount of splenic autotransplantation was performed |
| title_short | Revitalize splenic functions. Following a splenectomy for trauma, a small amount of splenic autotransplantation was performed |
| title_sort | revitalize splenic functions following a splenectomy for trauma a small amount of splenic autotransplantation was performed |
| topic | Autotransplantation Splenectomy Trauma Splenic functions |
| url | https://doi.org/10.1186/s12893-023-02126-z |
| work_keys_str_mv | AT hassanasaad revitalizesplenicfunctionsfollowingasplenectomyfortraumaasmallamountofsplenicautotransplantationwasperformed AT rashaselsayed revitalizesplenicfunctionsfollowingasplenectomyfortraumaasmallamountofsplenicautotransplantationwasperformed AT mohamedriad revitalizesplenicfunctionsfollowingasplenectomyfortraumaasmallamountofsplenicautotransplantationwasperformed AT ahmedkeltaher revitalizesplenicfunctionsfollowingasplenectomyfortraumaasmallamountofsplenicautotransplantationwasperformed AT mohamedeeraky revitalizesplenicfunctionsfollowingasplenectomyfortraumaasmallamountofsplenicautotransplantationwasperformed AT ashrafabdelmonem revitalizesplenicfunctionsfollowingasplenectomyfortraumaasmallamountofsplenicautotransplantationwasperformed |