Neurotrophins in Zebrafish Taste Buds
The neurotrophin family is composed of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), Neurotrophin 3 (NT3) and NT4. These neurotrophins regulate several crucial functions through the activation of two types of transmembrane receptors, namely p75, which binds all neurotrophins w...
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| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/12/13/1613 |
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| author | Claudia Gatta Valentina Schiano Chiara Attanasio Carla Lucini Antonio Palladino |
| author_facet | Claudia Gatta Valentina Schiano Chiara Attanasio Carla Lucini Antonio Palladino |
| author_sort | Claudia Gatta |
| collection | DOAJ |
| description | The neurotrophin family is composed of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), Neurotrophin 3 (NT3) and NT4. These neurotrophins regulate several crucial functions through the activation of two types of transmembrane receptors, namely p75, which binds all neurotrophins with a similar affinity, and tyrosine kinase (Trk) receptors. Neurotrophins, besides their well-known pivotal role in the development and maintenance of the nervous system, also display the ability to regulate the development of taste buds in mammals. Therefore, the aim of this study is to investigate if NGF, BDNF, NT3 and NT4 are also present in the taste buds of zebrafish (<i>Danio rerio</i>), a powerful vertebrate model organism. Morphological analyses carried out on adult zebrafish showed the presence of neurotrophins in taste bud cells of the oropharyngeal cavity, also suggesting that BDNF positive cells are the prevalent cell population in the posterior part of the oropharyngeal region. In conclusion, by suggesting that all tested neurotrophins are present in zebrafish sensory cells, our results lead to the assumption that taste bud cells in this fish species contain the same homologous neurotrophins reported in mammals, further confirming the high impact of the zebrafish model in translational research. |
| first_indexed | 2024-03-09T22:11:50Z |
| format | Article |
| id | doaj.art-edc3ac996088489f93bda71063ab3b63 |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-09T22:11:50Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-edc3ac996088489f93bda71063ab3b632023-11-23T19:31:54ZengMDPI AGAnimals2076-26152022-06-011213161310.3390/ani12131613Neurotrophins in Zebrafish Taste BudsClaudia Gatta0Valentina Schiano1Chiara Attanasio2Carla Lucini3Antonio Palladino4Department Veterinary Medicine and Animal Production, University of Naples Federico II, Via F. Delpino 1, 80137 Naples, ItalyDepartment Veterinary Medicine and Animal Production, University of Naples Federico II, Via F. Delpino 1, 80137 Naples, ItalyDepartment Veterinary Medicine and Animal Production, University of Naples Federico II, Via F. Delpino 1, 80137 Naples, ItalyDepartment Veterinary Medicine and Animal Production, University of Naples Federico II, Via F. Delpino 1, 80137 Naples, ItalyDepartment Agricultural Sciences, University of Naples Federico II, Via Università 100, 80055 Portici, ItalyThe neurotrophin family is composed of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), Neurotrophin 3 (NT3) and NT4. These neurotrophins regulate several crucial functions through the activation of two types of transmembrane receptors, namely p75, which binds all neurotrophins with a similar affinity, and tyrosine kinase (Trk) receptors. Neurotrophins, besides their well-known pivotal role in the development and maintenance of the nervous system, also display the ability to regulate the development of taste buds in mammals. Therefore, the aim of this study is to investigate if NGF, BDNF, NT3 and NT4 are also present in the taste buds of zebrafish (<i>Danio rerio</i>), a powerful vertebrate model organism. Morphological analyses carried out on adult zebrafish showed the presence of neurotrophins in taste bud cells of the oropharyngeal cavity, also suggesting that BDNF positive cells are the prevalent cell population in the posterior part of the oropharyngeal region. In conclusion, by suggesting that all tested neurotrophins are present in zebrafish sensory cells, our results lead to the assumption that taste bud cells in this fish species contain the same homologous neurotrophins reported in mammals, further confirming the high impact of the zebrafish model in translational research.https://www.mdpi.com/2076-2615/12/13/1613nerve growth factor (NGF)brain derived neurotrophic factor (BDNF)Neurotrophin 3 (NT3)Neurotrophin 4 (NT4)taste buds (TBs) |
| spellingShingle | Claudia Gatta Valentina Schiano Chiara Attanasio Carla Lucini Antonio Palladino Neurotrophins in Zebrafish Taste Buds Animals nerve growth factor (NGF) brain derived neurotrophic factor (BDNF) Neurotrophin 3 (NT3) Neurotrophin 4 (NT4) taste buds (TBs) |
| title | Neurotrophins in Zebrafish Taste Buds |
| title_full | Neurotrophins in Zebrafish Taste Buds |
| title_fullStr | Neurotrophins in Zebrafish Taste Buds |
| title_full_unstemmed | Neurotrophins in Zebrafish Taste Buds |
| title_short | Neurotrophins in Zebrafish Taste Buds |
| title_sort | neurotrophins in zebrafish taste buds |
| topic | nerve growth factor (NGF) brain derived neurotrophic factor (BDNF) Neurotrophin 3 (NT3) Neurotrophin 4 (NT4) taste buds (TBs) |
| url | https://www.mdpi.com/2076-2615/12/13/1613 |
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