Effect of Prepartum Maternal Supplementation with Diphenyl Diselenide on Biochemical, Immunological, and Oxidative Parameters of the Offspring
This study aimed to assess the impact of prepartum maternal diphenyl diselenide (PhSe)<sub>2</sub> supplementation on the development, biochemical, immune, and antioxidant parameters of calves. Eighteen Holstein breed calves were used, born to females who were or were not subjected to su...
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| Format: | Article |
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MDPI AG
2023-12-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/14/1/10 |
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| author | Cláudia Medeiros Rodrigues Eliana Burtet Parmeggiani Karoline Wagner Leal Marla Schneider Silvana Giacomini Collet Francielli Weber Santos Cibin Viviani Gomes Maiara Garcia Blagitz João Batista Teixeira da Rocha Marta Lizandra do Rêgo Leal |
| author_facet | Cláudia Medeiros Rodrigues Eliana Burtet Parmeggiani Karoline Wagner Leal Marla Schneider Silvana Giacomini Collet Francielli Weber Santos Cibin Viviani Gomes Maiara Garcia Blagitz João Batista Teixeira da Rocha Marta Lizandra do Rêgo Leal |
| author_sort | Cláudia Medeiros Rodrigues |
| collection | DOAJ |
| description | This study aimed to assess the impact of prepartum maternal diphenyl diselenide (PhSe)<sub>2</sub> supplementation on the development, biochemical, immune, and antioxidant parameters of calves. Eighteen Holstein breed calves were used, born to females who were or were not subjected to supplementation, at 42, 28, and 14 days prior to calving. The (PhSe)<sub>2</sub> group (DDG) was administered 3 μmol/kg of (PhSe)<sub>2</sub> in 4 mL of dimethyl sulfoxide (DMSO), while the DMSO and NaCl groups were administered 4 mL of DMSO and 0.9% NaCl, subcutaneously. The calves were evaluated based on their weight, withers height, body condition score 24 h post-birth (0), as well on days 14, 28, 42, 56, 70. Blood samples were also taken to determine serum variables. Calves on the DDG showed higher average levels of total protein, albumin, and globulins on day 0, and the immunoglobulin G level was significantly higher than the other groups on days 0, 14, 56, 70. Maternal supplementation showed immunomodulatory effect on calves, evidenced by the exceptional rates of passive immunity transfer, as well as the enhancement of humoral immunity. Our research offers fresh insights into the immunomodulatory potential of (PhSe)<sub>2</sub>, making it a viable alternative in facing this challenging phase, rearing dairy calves. |
| first_indexed | 2024-03-08T15:13:03Z |
| format | Article |
| id | doaj.art-edc437e92763418d85c2c535e7d56470 |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-08T15:13:03Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-edc437e92763418d85c2c535e7d564702024-01-10T14:49:52ZengMDPI AGAnimals2076-26152023-12-011411010.3390/ani14010010Effect of Prepartum Maternal Supplementation with Diphenyl Diselenide on Biochemical, Immunological, and Oxidative Parameters of the OffspringCláudia Medeiros Rodrigues0Eliana Burtet Parmeggiani1Karoline Wagner Leal2Marla Schneider3Silvana Giacomini Collet4Francielli Weber Santos Cibin5Viviani Gomes6Maiara Garcia Blagitz7João Batista Teixeira da Rocha8Marta Lizandra do Rêgo Leal9Department of Large Animal Clinic, Federal University of Santa Maria, Santa Maria 97105-900, RS, BrazilDepartment of Large Animal Clinic, Federal University of Santa Maria, Santa Maria 97105-900, RS, BrazilDepartment of Large Animal Clinic, Federal University of Santa Maria, Santa Maria 97105-900, RS, BrazilVeterinary Medicine Course, Central Education Unit Faem Faculty, Chapecó 89812-214, SC, BrazilVeterinary Medicine Course, University of West Santa Catarina, Xanxerê 89820-000, SC, BrazilOxidative Stress Laboratory, Federal University of Pampa, Uruguaiana 97501-970, RS, BrazilDepartment of Clinical Medicine, Faculty of Veterinary Medicine and Zootechnics, University of São Paulo, São Paulo 05508-270, SP, BrazilVeterinary Medicine Course, Federal University of the Southern Border, Realeza 85770-000, PR, BrazilDepartment of Biochemical and Molecular Biology, Federal University of Santa Maria, Santa Maria 97105-900, RS, BrazilDepartment of Large Animal Clinic, Federal University of Santa Maria, Santa Maria 97105-900, RS, BrazilThis study aimed to assess the impact of prepartum maternal diphenyl diselenide (PhSe)<sub>2</sub> supplementation on the development, biochemical, immune, and antioxidant parameters of calves. Eighteen Holstein breed calves were used, born to females who were or were not subjected to supplementation, at 42, 28, and 14 days prior to calving. The (PhSe)<sub>2</sub> group (DDG) was administered 3 μmol/kg of (PhSe)<sub>2</sub> in 4 mL of dimethyl sulfoxide (DMSO), while the DMSO and NaCl groups were administered 4 mL of DMSO and 0.9% NaCl, subcutaneously. The calves were evaluated based on their weight, withers height, body condition score 24 h post-birth (0), as well on days 14, 28, 42, 56, 70. Blood samples were also taken to determine serum variables. Calves on the DDG showed higher average levels of total protein, albumin, and globulins on day 0, and the immunoglobulin G level was significantly higher than the other groups on days 0, 14, 56, 70. Maternal supplementation showed immunomodulatory effect on calves, evidenced by the exceptional rates of passive immunity transfer, as well as the enhancement of humoral immunity. Our research offers fresh insights into the immunomodulatory potential of (PhSe)<sub>2</sub>, making it a viable alternative in facing this challenging phase, rearing dairy calves.https://www.mdpi.com/2076-2615/14/1/10cattlediphenyl diselenideimmunitysupplementation |
| spellingShingle | Cláudia Medeiros Rodrigues Eliana Burtet Parmeggiani Karoline Wagner Leal Marla Schneider Silvana Giacomini Collet Francielli Weber Santos Cibin Viviani Gomes Maiara Garcia Blagitz João Batista Teixeira da Rocha Marta Lizandra do Rêgo Leal Effect of Prepartum Maternal Supplementation with Diphenyl Diselenide on Biochemical, Immunological, and Oxidative Parameters of the Offspring Animals cattle diphenyl diselenide immunity supplementation |
| title | Effect of Prepartum Maternal Supplementation with Diphenyl Diselenide on Biochemical, Immunological, and Oxidative Parameters of the Offspring |
| title_full | Effect of Prepartum Maternal Supplementation with Diphenyl Diselenide on Biochemical, Immunological, and Oxidative Parameters of the Offspring |
| title_fullStr | Effect of Prepartum Maternal Supplementation with Diphenyl Diselenide on Biochemical, Immunological, and Oxidative Parameters of the Offspring |
| title_full_unstemmed | Effect of Prepartum Maternal Supplementation with Diphenyl Diselenide on Biochemical, Immunological, and Oxidative Parameters of the Offspring |
| title_short | Effect of Prepartum Maternal Supplementation with Diphenyl Diselenide on Biochemical, Immunological, and Oxidative Parameters of the Offspring |
| title_sort | effect of prepartum maternal supplementation with diphenyl diselenide on biochemical immunological and oxidative parameters of the offspring |
| topic | cattle diphenyl diselenide immunity supplementation |
| url | https://www.mdpi.com/2076-2615/14/1/10 |
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