Syntheses of Precursors and Reference Compounds of the Melanin-Concentrating Hormone Receptor 1 (MCHR1) Tracers [11C]SNAP-7941 and [18F]FE@SNAP for Positron Emission Tomography
The MCH receptor has been revealed as a target of great interest in positron emission tomography imaging. The receptor′s eponymous substrate melanin-concentrating hormone (MCH) is a cyclic peptide hormone, which is located predominantly in the hypothalamus with a major influence on energy and weight...
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| Format: | Article |
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MDPI AG
2013-09-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/18/10/12119 |
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| author | Cécile Philippe Wolfgang Wadsak Catharina Neudorfer Markus Mitterhauser Karem Shanab Barbara Datterl Eva Schirmer Helmut Spreitzer |
| author_facet | Cécile Philippe Wolfgang Wadsak Catharina Neudorfer Markus Mitterhauser Karem Shanab Barbara Datterl Eva Schirmer Helmut Spreitzer |
| author_sort | Cécile Philippe |
| collection | DOAJ |
| description | The MCH receptor has been revealed as a target of great interest in positron emission tomography imaging. The receptor′s eponymous substrate melanin-concentrating hormone (MCH) is a cyclic peptide hormone, which is located predominantly in the hypothalamus with a major influence on energy and weight regulation as well as water balance and memory. Therefore, it is thought to play an important role in the pathophysiology of adiposity, which is nowadays a big issue worldwide. Based on the selective and high-affinity MCH receptor 1 antagonist SNAP-7941, a series of novel SNAP derivatives has been developed to provide different precursors and reference compounds for the radiosyntheses of the novel PET radiotracers [11C]SNAP-7941 and [18F]FE@SNAP. Positron emission tomography promotes a better understanding of physiologic parameters on a molecular level, thus giving a deeper insight into MCHR1 related processes as adiposity. |
| first_indexed | 2024-12-22T11:11:23Z |
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| id | doaj.art-edc48db384884f54a5f5f8e120fe764a |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-22T11:11:23Z |
| publishDate | 2013-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-edc48db384884f54a5f5f8e120fe764a2022-12-21T18:28:09ZengMDPI AGMolecules1420-30492013-09-011810121191214310.3390/molecules181012119Syntheses of Precursors and Reference Compounds of the Melanin-Concentrating Hormone Receptor 1 (MCHR1) Tracers [11C]SNAP-7941 and [18F]FE@SNAP for Positron Emission TomographyCécile PhilippeWolfgang WadsakCatharina NeudorferMarkus MitterhauserKarem ShanabBarbara DatterlEva SchirmerHelmut SpreitzerThe MCH receptor has been revealed as a target of great interest in positron emission tomography imaging. The receptor′s eponymous substrate melanin-concentrating hormone (MCH) is a cyclic peptide hormone, which is located predominantly in the hypothalamus with a major influence on energy and weight regulation as well as water balance and memory. Therefore, it is thought to play an important role in the pathophysiology of adiposity, which is nowadays a big issue worldwide. Based on the selective and high-affinity MCH receptor 1 antagonist SNAP-7941, a series of novel SNAP derivatives has been developed to provide different precursors and reference compounds for the radiosyntheses of the novel PET radiotracers [11C]SNAP-7941 and [18F]FE@SNAP. Positron emission tomography promotes a better understanding of physiologic parameters on a molecular level, thus giving a deeper insight into MCHR1 related processes as adiposity.http://www.mdpi.com/1420-3049/18/10/12119MCH receptor 1 (MCHR1)SNAP-7941racSNAP-7941positron emission tomographyadiposity |
| spellingShingle | Cécile Philippe Wolfgang Wadsak Catharina Neudorfer Markus Mitterhauser Karem Shanab Barbara Datterl Eva Schirmer Helmut Spreitzer Syntheses of Precursors and Reference Compounds of the Melanin-Concentrating Hormone Receptor 1 (MCHR1) Tracers [11C]SNAP-7941 and [18F]FE@SNAP for Positron Emission Tomography Molecules MCH receptor 1 (MCHR1) SNAP-7941 racSNAP-7941 positron emission tomography adiposity |
| title | Syntheses of Precursors and Reference Compounds of the Melanin-Concentrating Hormone Receptor 1 (MCHR1) Tracers [11C]SNAP-7941 and [18F]FE@SNAP for Positron Emission Tomography |
| title_full | Syntheses of Precursors and Reference Compounds of the Melanin-Concentrating Hormone Receptor 1 (MCHR1) Tracers [11C]SNAP-7941 and [18F]FE@SNAP for Positron Emission Tomography |
| title_fullStr | Syntheses of Precursors and Reference Compounds of the Melanin-Concentrating Hormone Receptor 1 (MCHR1) Tracers [11C]SNAP-7941 and [18F]FE@SNAP for Positron Emission Tomography |
| title_full_unstemmed | Syntheses of Precursors and Reference Compounds of the Melanin-Concentrating Hormone Receptor 1 (MCHR1) Tracers [11C]SNAP-7941 and [18F]FE@SNAP for Positron Emission Tomography |
| title_short | Syntheses of Precursors and Reference Compounds of the Melanin-Concentrating Hormone Receptor 1 (MCHR1) Tracers [11C]SNAP-7941 and [18F]FE@SNAP for Positron Emission Tomography |
| title_sort | syntheses of precursors and reference compounds of the melanin concentrating hormone receptor 1 mchr1 tracers 11c snap 7941 and 18f fe snap for positron emission tomography |
| topic | MCH receptor 1 (MCHR1) SNAP-7941 racSNAP-7941 positron emission tomography adiposity |
| url | http://www.mdpi.com/1420-3049/18/10/12119 |
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