Sex-dependent factors of alcohol and neuroimmune mechanisms
Excessive alcohol use disrupts neuroimmune signaling across various cell types, including neurons, microglia, and astrocytes. The present review focuses on recent, albeit limited, evidence of sex differences in biological factors that mediate neuroimmune responses to alcohol and underlying neuroimmu...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-09-01
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| Series: | Neurobiology of Stress |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352289523000504 |
| _version_ | 1797677716120535040 |
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| author | Bryan Cruz Vittoria Borgonetti Michal Bajo Marisa Roberto |
| author_facet | Bryan Cruz Vittoria Borgonetti Michal Bajo Marisa Roberto |
| author_sort | Bryan Cruz |
| collection | DOAJ |
| description | Excessive alcohol use disrupts neuroimmune signaling across various cell types, including neurons, microglia, and astrocytes. The present review focuses on recent, albeit limited, evidence of sex differences in biological factors that mediate neuroimmune responses to alcohol and underlying neuroimmune systems that may influence alcohol drinking behaviors. Females are more vulnerable than males to the neurotoxic and negative consequences of chronic alcohol drinking, reflected by elevations of pro-inflammatory cytokines and inflammatory mediators. Differences in cytokine, microglial, astrocytic, genomic, and transcriptomic evidence suggest females are more reactive than males to neuroinflammatory changes after chronic alcohol exposure. The growing body of evidence supports that innate immune factors modulate synaptic transmission, providing a mechanistic framework to examine sex differences across neurocircuitry. Targeting neuroimmune signaling may be a viable strategy for treating AUD, but more research is needed to understand sex-specific differences in alcohol drinking and neuroimmune mechanisms. |
| first_indexed | 2024-03-11T22:49:16Z |
| format | Article |
| id | doaj.art-edc555a4abaa4d5b94283f55cdfd49af |
| institution | Directory Open Access Journal |
| issn | 2352-2895 |
| language | English |
| last_indexed | 2024-03-11T22:49:16Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Stress |
| spelling | doaj.art-edc555a4abaa4d5b94283f55cdfd49af2023-09-22T04:38:56ZengElsevierNeurobiology of Stress2352-28952023-09-0126100562Sex-dependent factors of alcohol and neuroimmune mechanismsBryan Cruz0Vittoria Borgonetti1Michal Bajo2Marisa Roberto3Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA, 92073Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA, 92073Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA, 92073Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA, 92073; Corresponding author.Excessive alcohol use disrupts neuroimmune signaling across various cell types, including neurons, microglia, and astrocytes. The present review focuses on recent, albeit limited, evidence of sex differences in biological factors that mediate neuroimmune responses to alcohol and underlying neuroimmune systems that may influence alcohol drinking behaviors. Females are more vulnerable than males to the neurotoxic and negative consequences of chronic alcohol drinking, reflected by elevations of pro-inflammatory cytokines and inflammatory mediators. Differences in cytokine, microglial, astrocytic, genomic, and transcriptomic evidence suggest females are more reactive than males to neuroinflammatory changes after chronic alcohol exposure. The growing body of evidence supports that innate immune factors modulate synaptic transmission, providing a mechanistic framework to examine sex differences across neurocircuitry. Targeting neuroimmune signaling may be a viable strategy for treating AUD, but more research is needed to understand sex-specific differences in alcohol drinking and neuroimmune mechanisms.http://www.sciencedirect.com/science/article/pii/S2352289523000504AlcoholNeuroimmuneCytokineMicrogliaAstrocyteSex differences |
| spellingShingle | Bryan Cruz Vittoria Borgonetti Michal Bajo Marisa Roberto Sex-dependent factors of alcohol and neuroimmune mechanisms Neurobiology of Stress Alcohol Neuroimmune Cytokine Microglia Astrocyte Sex differences |
| title | Sex-dependent factors of alcohol and neuroimmune mechanisms |
| title_full | Sex-dependent factors of alcohol and neuroimmune mechanisms |
| title_fullStr | Sex-dependent factors of alcohol and neuroimmune mechanisms |
| title_full_unstemmed | Sex-dependent factors of alcohol and neuroimmune mechanisms |
| title_short | Sex-dependent factors of alcohol and neuroimmune mechanisms |
| title_sort | sex dependent factors of alcohol and neuroimmune mechanisms |
| topic | Alcohol Neuroimmune Cytokine Microglia Astrocyte Sex differences |
| url | http://www.sciencedirect.com/science/article/pii/S2352289523000504 |
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