Evaluation of Antibacterial and Anticandidal Activities of Some Imidazole, Benzimidazole and Benztriazole Derivatives
In recent years, resistance to conventional antimicrobial drugs has become a serious concern in the clinic. Hence, the discovery of novel and effective antimicrobial agents with improved properties is of great value. In this study, the antibacterial and anticandidal activities of some imidazole, ben...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Shiraz University of Medical Sciences
2022-06-01
|
| Series: | Trends in Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | https://tips.sums.ac.ir/article_48352_4ab7afd34f0e27d358aadf89c7e6d892.pdf |
| _version_ | 1817970639404793856 |
|---|---|
| author | Sara Sadeghian Ahmad Gholami Soghra Khabnadideh Razieh Razmi Issa Sadeghian Younes Ghasemi Zahra Rezaei |
| author_facet | Sara Sadeghian Ahmad Gholami Soghra Khabnadideh Razieh Razmi Issa Sadeghian Younes Ghasemi Zahra Rezaei |
| author_sort | Sara Sadeghian |
| collection | DOAJ |
| description | In recent years, resistance to conventional antimicrobial drugs has become a serious concern in the clinic. Hence, the discovery of novel and effective antimicrobial agents with improved properties is of great value. In this study, the antibacterial and anticandidal activities of some imidazole, benzimidazole and benztriazole derivatives (C1-C8) against several species of Gram-positive and Gram-negative bacteria, including Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli and Salmonella typhi as well as one species of fungi including Candida albicans, were evaluated using Clinical & Laboratory Standards Institute (CLSI) method. Antimicrobial evaluation revealed that among the tested compounds, imidazole derivative (C5) indicated the highest activity against bacterial strains and Candida albicans. It was found that compound C5 is more potent than ampicillin against S. aureus strain (MIC =2-16 µg/mL) and possessed excellent anticandidal activity (MIC =1 µg/mL) which was comparable to Amphotericin B as the positive control. In addition, cytotoxic activity of the tested compounds was investigated using MTT assay. The results of MTT assay demonstrated that the toxicity of the tested compounds was less than 35%. Please cite this article as: Sara Sadeghian, Ahmad Gholami, Soghra Khabnadideh, Razieh Razmi, Issa Sadeghain, Younes Ghasemi & Zahra Rezaei. Evaluation of Antibacterial and Anticandidal Activities of Some Imidazole, Benzimidazole and Benztriazole Derivatives. Trends in Pharmaceutical Sciences. 2022;8(2):75-84 .doi: 10.30476/TIPS.2022.93637.1126 |
| first_indexed | 2024-04-13T20:36:38Z |
| format | Article |
| id | doaj.art-edc5b76ae1ab4d50a11f9feaac8168e1 |
| institution | Directory Open Access Journal |
| issn | 2423-5652 |
| language | English |
| last_indexed | 2024-04-13T20:36:38Z |
| publishDate | 2022-06-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Trends in Pharmaceutical Sciences |
| spelling | doaj.art-edc5b76ae1ab4d50a11f9feaac8168e12022-12-22T02:31:01ZengShiraz University of Medical SciencesTrends in Pharmaceutical Sciences2423-56522022-06-0182758410.30476/tips.2022.93637.112648352Evaluation of Antibacterial and Anticandidal Activities of Some Imidazole, Benzimidazole and Benztriazole DerivativesSara Sadeghian0Ahmad Gholami1Soghra Khabnadideh2Razieh Razmi3Issa Sadeghian4Younes Ghasemi5Zahra Rezaei6Department of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, IranBiotechnology Research Center, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, IranPharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, IranPharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, IranIn recent years, resistance to conventional antimicrobial drugs has become a serious concern in the clinic. Hence, the discovery of novel and effective antimicrobial agents with improved properties is of great value. In this study, the antibacterial and anticandidal activities of some imidazole, benzimidazole and benztriazole derivatives (C1-C8) against several species of Gram-positive and Gram-negative bacteria, including Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli and Salmonella typhi as well as one species of fungi including Candida albicans, were evaluated using Clinical & Laboratory Standards Institute (CLSI) method. Antimicrobial evaluation revealed that among the tested compounds, imidazole derivative (C5) indicated the highest activity against bacterial strains and Candida albicans. It was found that compound C5 is more potent than ampicillin against S. aureus strain (MIC =2-16 µg/mL) and possessed excellent anticandidal activity (MIC =1 µg/mL) which was comparable to Amphotericin B as the positive control. In addition, cytotoxic activity of the tested compounds was investigated using MTT assay. The results of MTT assay demonstrated that the toxicity of the tested compounds was less than 35%. Please cite this article as: Sara Sadeghian, Ahmad Gholami, Soghra Khabnadideh, Razieh Razmi, Issa Sadeghain, Younes Ghasemi & Zahra Rezaei. Evaluation of Antibacterial and Anticandidal Activities of Some Imidazole, Benzimidazole and Benztriazole Derivatives. Trends in Pharmaceutical Sciences. 2022;8(2):75-84 .doi: 10.30476/TIPS.2022.93637.1126https://tips.sums.ac.ir/article_48352_4ab7afd34f0e27d358aadf89c7e6d892.pdfazolesantimicrobial effectantifungal activitymtt |
| spellingShingle | Sara Sadeghian Ahmad Gholami Soghra Khabnadideh Razieh Razmi Issa Sadeghian Younes Ghasemi Zahra Rezaei Evaluation of Antibacterial and Anticandidal Activities of Some Imidazole, Benzimidazole and Benztriazole Derivatives Trends in Pharmaceutical Sciences azoles antimicrobial effect antifungal activity mtt |
| title | Evaluation of Antibacterial and Anticandidal Activities of Some Imidazole, Benzimidazole and Benztriazole Derivatives |
| title_full | Evaluation of Antibacterial and Anticandidal Activities of Some Imidazole, Benzimidazole and Benztriazole Derivatives |
| title_fullStr | Evaluation of Antibacterial and Anticandidal Activities of Some Imidazole, Benzimidazole and Benztriazole Derivatives |
| title_full_unstemmed | Evaluation of Antibacterial and Anticandidal Activities of Some Imidazole, Benzimidazole and Benztriazole Derivatives |
| title_short | Evaluation of Antibacterial and Anticandidal Activities of Some Imidazole, Benzimidazole and Benztriazole Derivatives |
| title_sort | evaluation of antibacterial and anticandidal activities of some imidazole benzimidazole and benztriazole derivatives |
| topic | azoles antimicrobial effect antifungal activity mtt |
| url | https://tips.sums.ac.ir/article_48352_4ab7afd34f0e27d358aadf89c7e6d892.pdf |
| work_keys_str_mv | AT sarasadeghian evaluationofantibacterialandanticandidalactivitiesofsomeimidazolebenzimidazoleandbenztriazolederivatives AT ahmadgholami evaluationofantibacterialandanticandidalactivitiesofsomeimidazolebenzimidazoleandbenztriazolederivatives AT soghrakhabnadideh evaluationofantibacterialandanticandidalactivitiesofsomeimidazolebenzimidazoleandbenztriazolederivatives AT raziehrazmi evaluationofantibacterialandanticandidalactivitiesofsomeimidazolebenzimidazoleandbenztriazolederivatives AT issasadeghian evaluationofantibacterialandanticandidalactivitiesofsomeimidazolebenzimidazoleandbenztriazolederivatives AT younesghasemi evaluationofantibacterialandanticandidalactivitiesofsomeimidazolebenzimidazoleandbenztriazolederivatives AT zahrarezaei evaluationofantibacterialandanticandidalactivitiesofsomeimidazolebenzimidazoleandbenztriazolederivatives |