Toward a Cognitive Neural Prosthesis Using Focused Ultrasound
Non-invasive brain stimulation using focused ultrasound has many potential applications as a research and clinical tool, including its incorporation as either an extracorporeal or implantable neural prosthetic. To this end, we investigated the effect of focused ultrasound (FUS) combined with systemi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-11-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fnins.2017.00607/full |
| _version_ | 1818196837688934400 |
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| author | Matthew E. Downs Tobias Teichert Amanda Buch Maria E. Karakatsani Carlos Sierra Shangshang Chen Elisa E. Konofagou Elisa E. Konofagou Vincent P. Ferrera Vincent P. Ferrera |
| author_facet | Matthew E. Downs Tobias Teichert Amanda Buch Maria E. Karakatsani Carlos Sierra Shangshang Chen Elisa E. Konofagou Elisa E. Konofagou Vincent P. Ferrera Vincent P. Ferrera |
| author_sort | Matthew E. Downs |
| collection | DOAJ |
| description | Non-invasive brain stimulation using focused ultrasound has many potential applications as a research and clinical tool, including its incorporation as either an extracorporeal or implantable neural prosthetic. To this end, we investigated the effect of focused ultrasound (FUS) combined with systemically administered microbubbles on visual-motor decision-making behavior in monkeys. We applied FUS to the putamen in one hemisphere to open the blood-brain barrier (BBB), and then tested behavioral performance 3–4 h later. On days when the monkeys were treated with FUS, their decisions were faster and more accurate than days without sonication. The performance improvement suggested both a shift in the decision criterion and an enhancement of the use of sensory evidence in the decision process. FUS also interacted with the effect of a low dose of haloperidol. The findings indicate that a two-minute application of FUS can have a sustained impact on performance of complex cognitive tasks, and may increase the efficacy of psychoactive medications. The results lend further support to the idea that the dorsal striatum plays an integral role in evidence- and reward-based decision-making, and provide motivation for incorporating FUS into cognitive neural prosthetic devices. |
| first_indexed | 2024-12-12T01:40:26Z |
| format | Article |
| id | doaj.art-edc75b07554c4c649e24936f3e014d0c |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-12T01:40:26Z |
| publishDate | 2017-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-edc75b07554c4c649e24936f3e014d0c2022-12-22T00:42:44ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2017-11-011110.3389/fnins.2017.00607272648Toward a Cognitive Neural Prosthesis Using Focused UltrasoundMatthew E. Downs0Tobias Teichert1Amanda Buch2Maria E. Karakatsani3Carlos Sierra4Shangshang Chen5Elisa E. Konofagou6Elisa E. Konofagou7Vincent P. Ferrera8Vincent P. Ferrera9Department of Biomedical Engineering, Columbia University, New York, NY, United StatesDepartment of Neuroscience, Columbia University, New York, NY, United StatesDepartment of Biomedical Engineering, Columbia University, New York, NY, United StatesDepartment of Biomedical Engineering, Columbia University, New York, NY, United StatesDepartment of Biomedical Engineering, Columbia University, New York, NY, United StatesDepartment of Neuroscience, Columbia University, New York, NY, United StatesDepartment of Biomedical Engineering, Columbia University, New York, NY, United StatesDepartment of Radiology, Columbia University, New York, NY, United StatesDepartment of Neuroscience, Columbia University, New York, NY, United StatesDepartment of Psychiatry, Columbia University, New York, NY, United StatesNon-invasive brain stimulation using focused ultrasound has many potential applications as a research and clinical tool, including its incorporation as either an extracorporeal or implantable neural prosthetic. To this end, we investigated the effect of focused ultrasound (FUS) combined with systemically administered microbubbles on visual-motor decision-making behavior in monkeys. We applied FUS to the putamen in one hemisphere to open the blood-brain barrier (BBB), and then tested behavioral performance 3–4 h later. On days when the monkeys were treated with FUS, their decisions were faster and more accurate than days without sonication. The performance improvement suggested both a shift in the decision criterion and an enhancement of the use of sensory evidence in the decision process. FUS also interacted with the effect of a low dose of haloperidol. The findings indicate that a two-minute application of FUS can have a sustained impact on performance of complex cognitive tasks, and may increase the efficacy of psychoactive medications. The results lend further support to the idea that the dorsal striatum plays an integral role in evidence- and reward-based decision-making, and provide motivation for incorporating FUS into cognitive neural prosthetic devices.http://journal.frontiersin.org/article/10.3389/fnins.2017.00607/fullblood-brain barrierfocused ultrasound stimulationdecision makingNHP modeldrug delivery |
| spellingShingle | Matthew E. Downs Tobias Teichert Amanda Buch Maria E. Karakatsani Carlos Sierra Shangshang Chen Elisa E. Konofagou Elisa E. Konofagou Vincent P. Ferrera Vincent P. Ferrera Toward a Cognitive Neural Prosthesis Using Focused Ultrasound Frontiers in Neuroscience blood-brain barrier focused ultrasound stimulation decision making NHP model drug delivery |
| title | Toward a Cognitive Neural Prosthesis Using Focused Ultrasound |
| title_full | Toward a Cognitive Neural Prosthesis Using Focused Ultrasound |
| title_fullStr | Toward a Cognitive Neural Prosthesis Using Focused Ultrasound |
| title_full_unstemmed | Toward a Cognitive Neural Prosthesis Using Focused Ultrasound |
| title_short | Toward a Cognitive Neural Prosthesis Using Focused Ultrasound |
| title_sort | toward a cognitive neural prosthesis using focused ultrasound |
| topic | blood-brain barrier focused ultrasound stimulation decision making NHP model drug delivery |
| url | http://journal.frontiersin.org/article/10.3389/fnins.2017.00607/full |
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