Synthesis of Tubular Hydroxyapatite and Its Application in Polycaprolactone Scaffold Materials
Nano-hydroxyapatite (HAp) is an ideal material in the field of biomedicine due to its good biocompatibility and bioactivity. However, a significant drawback of pure HAp materials is their inferior mechanical properties. Therefore, in this rigorous investigation, the optimal calcium-to-phosphorus rat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/15/1/22 |
| _version_ | 1827371798005547008 |
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| author | Ziyi Hong Shaohui Wang Fengyu Liu |
| author_facet | Ziyi Hong Shaohui Wang Fengyu Liu |
| author_sort | Ziyi Hong |
| collection | DOAJ |
| description | Nano-hydroxyapatite (HAp) is an ideal material in the field of biomedicine due to its good biocompatibility and bioactivity. However, a significant drawback of pure HAp materials is their inferior mechanical properties. Therefore, in this rigorous investigation, the optimal calcium-to-phosphorus ratio for the synthesis of HAp was meticulously delineated, followed by its nuanced modification using KH550 (γ-aminopropyltriethoxysilane). This was further amalgamated with polycaprolactone (PCL) with the aim of providing a superior material alternative within the domain of bone scaffold materials. The post-modified HAp demonstrated enhanced interfacial compatibility with PCL, bestowing the composite with superior mechanical characteristics, notably a peak bending strength of 6.38 ± 0.037 MPa and a tensile strength of 3.71 ± 0.040 MPa. Scanning electron microscope (SEM) imagery revealed an intriguing characteristic of the composite: an initial ascension in porosity upon HAp integration, subsequently followed by a decline. Beyond this, the composite not only exhibited stellar auto-degradation prowess but also realized a sustained release cycle of 24 h, markedly optimizing drug utility efficiency. A kinetic model for drug dispensation was developed, positing an adherence to a pseudo-second-order kinetic principle. In tandem, through the formulation of an intra-particle diffusion model, the diffusion mechanisms pre- and post-modification were deeply probed. Cytotoxicity assays underscored the composite’s exemplary biocompatibility. Such findings accentuate the vast potential of the modified HAp–PCL composite in bone tissue engineering, heralding a novel and efficacious avenue for impending bone defect amelioration. |
| first_indexed | 2024-03-08T10:46:45Z |
| format | Article |
| id | doaj.art-edc87ec5fe7849d3b13f594bd47be48c |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-08T10:46:45Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-edc87ec5fe7849d3b13f594bd47be48c2024-01-26T17:10:57ZengMDPI AGJournal of Functional Biomaterials2079-49832024-01-011512210.3390/jfb15010022Synthesis of Tubular Hydroxyapatite and Its Application in Polycaprolactone Scaffold MaterialsZiyi Hong0Shaohui Wang1Fengyu Liu2Department for Materials Science and Engineering, East China Jiao Tong University, Nanchang 330013, ChinaDepartment for Materials Science and Engineering, East China Jiao Tong University, Nanchang 330013, ChinaDepartment for Materials Science and Engineering, East China Jiao Tong University, Nanchang 330013, ChinaNano-hydroxyapatite (HAp) is an ideal material in the field of biomedicine due to its good biocompatibility and bioactivity. However, a significant drawback of pure HAp materials is their inferior mechanical properties. Therefore, in this rigorous investigation, the optimal calcium-to-phosphorus ratio for the synthesis of HAp was meticulously delineated, followed by its nuanced modification using KH550 (γ-aminopropyltriethoxysilane). This was further amalgamated with polycaprolactone (PCL) with the aim of providing a superior material alternative within the domain of bone scaffold materials. The post-modified HAp demonstrated enhanced interfacial compatibility with PCL, bestowing the composite with superior mechanical characteristics, notably a peak bending strength of 6.38 ± 0.037 MPa and a tensile strength of 3.71 ± 0.040 MPa. Scanning electron microscope (SEM) imagery revealed an intriguing characteristic of the composite: an initial ascension in porosity upon HAp integration, subsequently followed by a decline. Beyond this, the composite not only exhibited stellar auto-degradation prowess but also realized a sustained release cycle of 24 h, markedly optimizing drug utility efficiency. A kinetic model for drug dispensation was developed, positing an adherence to a pseudo-second-order kinetic principle. In tandem, through the formulation of an intra-particle diffusion model, the diffusion mechanisms pre- and post-modification were deeply probed. Cytotoxicity assays underscored the composite’s exemplary biocompatibility. Such findings accentuate the vast potential of the modified HAp–PCL composite in bone tissue engineering, heralding a novel and efficacious avenue for impending bone defect amelioration.https://www.mdpi.com/2079-4983/15/1/22PCLtubular HApartificial bone scaffoldγ-aminopropyltriethoxysilane (KH550)solvothermal reaction method |
| spellingShingle | Ziyi Hong Shaohui Wang Fengyu Liu Synthesis of Tubular Hydroxyapatite and Its Application in Polycaprolactone Scaffold Materials Journal of Functional Biomaterials PCL tubular HAp artificial bone scaffold γ-aminopropyltriethoxysilane (KH550) solvothermal reaction method |
| title | Synthesis of Tubular Hydroxyapatite and Its Application in Polycaprolactone Scaffold Materials |
| title_full | Synthesis of Tubular Hydroxyapatite and Its Application in Polycaprolactone Scaffold Materials |
| title_fullStr | Synthesis of Tubular Hydroxyapatite and Its Application in Polycaprolactone Scaffold Materials |
| title_full_unstemmed | Synthesis of Tubular Hydroxyapatite and Its Application in Polycaprolactone Scaffold Materials |
| title_short | Synthesis of Tubular Hydroxyapatite and Its Application in Polycaprolactone Scaffold Materials |
| title_sort | synthesis of tubular hydroxyapatite and its application in polycaprolactone scaffold materials |
| topic | PCL tubular HAp artificial bone scaffold γ-aminopropyltriethoxysilane (KH550) solvothermal reaction method |
| url | https://www.mdpi.com/2079-4983/15/1/22 |
| work_keys_str_mv | AT ziyihong synthesisoftubularhydroxyapatiteanditsapplicationinpolycaprolactonescaffoldmaterials AT shaohuiwang synthesisoftubularhydroxyapatiteanditsapplicationinpolycaprolactonescaffoldmaterials AT fengyuliu synthesisoftubularhydroxyapatiteanditsapplicationinpolycaprolactonescaffoldmaterials |