U-shaped association between serum uric acid concentration and mortality in hypertrophic cardiomyopathy patients
Background. No study has examined the effect of low serum uric acid (SUA) concentrations on mortality in hypertrophic cardiomyopathy (HCM) patients. The aim of the present study was to assess the relations between both low and high SUA concentrations and the risk of mortality across the full range o...
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| Format: | Article |
| Language: | English |
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Upsala Medical Society
2020-02-01
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| Series: | Upsala Journal of Medical Sciences |
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| Online Access: | http://dx.doi.org/10.1080/03009734.2020.1719245 |
| _version_ | 1797711343377186816 |
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| author | Ziqiong Wang Ying Xu Hang Liao Xiaoping Chen Sen He |
| author_facet | Ziqiong Wang Ying Xu Hang Liao Xiaoping Chen Sen He |
| author_sort | Ziqiong Wang |
| collection | DOAJ |
| description | Background. No study has examined the effect of low serum uric acid (SUA) concentrations on mortality in hypertrophic cardiomyopathy (HCM) patients. The aim of the present study was to assess the relations between both low and high SUA concentrations and the risk of mortality across the full range of SUA concentrations in a retrospective cohort of HCM patients. Methods. A total of 454 HCM patients were enrolled in the study, and SUA concentrations were measured at baseline. The primary and secondary endpoints were all-cause mortality and HCM-related mortality, respectively. The associations between SUA concentrations and endpoints were analysed. Results. During a median follow-up of 3.8 years, there were 80 (17.6%) all-cause mortality events, and 52 of them (11.5%) were ascribed to HCM-related mortality. Patients with SUA concentrations of 250–350 µmol/L had the lowest all-cause mortality rate (11.8%) and HCM-related mortality rate (5.0%). Both low and high SUA concentrations were associated with increased all-cause and HCM-related mortality. Adjusted HRs were 2.52 (95% CI 1.13–5.61, p = 0.024) and 4.86 (95% CI 1.74–13.58, p = 0.003) for all-cause mortality and HCM-related mortality in the lowest SUA group (<250 µmol/L) when compared with the reference group (250–350 µmol/L), respectively. The corresponding HRs in the highest SUA group (≥450 µmol/L) were 2.73 (95% CI 1.42–5.23, p = 0.003) and 4.14 (95% CI 1.70–10.13, p = 0.002), respectively. Conclusions. Both low and high SUA concentrations were significantly associated with increased risk of all-cause mortality and HCM-related mortality, which supported a U-shaped association between SUA concentrations and mortality in HCM patients. |
| first_indexed | 2024-03-12T07:05:43Z |
| format | Article |
| id | doaj.art-edcbb452f6a94196aeb2e85965b27ed1 |
| institution | Directory Open Access Journal |
| issn | 0300-9734 2000-1967 |
| language | English |
| last_indexed | 2024-03-12T07:05:43Z |
| publishDate | 2020-02-01 |
| publisher | Upsala Medical Society |
| record_format | Article |
| series | Upsala Journal of Medical Sciences |
| spelling | doaj.art-edcbb452f6a94196aeb2e85965b27ed12023-09-02T23:28:06ZengUpsala Medical SocietyUpsala Journal of Medical Sciences0300-97342000-19672020-02-01001810.1080/03009734.2020.17192451719245U-shaped association between serum uric acid concentration and mortality in hypertrophic cardiomyopathy patientsZiqiong Wang0Ying Xu1Hang Liao2Xiaoping Chen3Sen He4Sichuan UniversitySichuan UniversitySichuan UniversitySichuan UniversitySichuan UniversityBackground. No study has examined the effect of low serum uric acid (SUA) concentrations on mortality in hypertrophic cardiomyopathy (HCM) patients. The aim of the present study was to assess the relations between both low and high SUA concentrations and the risk of mortality across the full range of SUA concentrations in a retrospective cohort of HCM patients. Methods. A total of 454 HCM patients were enrolled in the study, and SUA concentrations were measured at baseline. The primary and secondary endpoints were all-cause mortality and HCM-related mortality, respectively. The associations between SUA concentrations and endpoints were analysed. Results. During a median follow-up of 3.8 years, there were 80 (17.6%) all-cause mortality events, and 52 of them (11.5%) were ascribed to HCM-related mortality. Patients with SUA concentrations of 250–350 µmol/L had the lowest all-cause mortality rate (11.8%) and HCM-related mortality rate (5.0%). Both low and high SUA concentrations were associated with increased all-cause and HCM-related mortality. Adjusted HRs were 2.52 (95% CI 1.13–5.61, p = 0.024) and 4.86 (95% CI 1.74–13.58, p = 0.003) for all-cause mortality and HCM-related mortality in the lowest SUA group (<250 µmol/L) when compared with the reference group (250–350 µmol/L), respectively. The corresponding HRs in the highest SUA group (≥450 µmol/L) were 2.73 (95% CI 1.42–5.23, p = 0.003) and 4.14 (95% CI 1.70–10.13, p = 0.002), respectively. Conclusions. Both low and high SUA concentrations were significantly associated with increased risk of all-cause mortality and HCM-related mortality, which supported a U-shaped association between SUA concentrations and mortality in HCM patients.http://dx.doi.org/10.1080/03009734.2020.1719245hypertrophic cardiomyopathymortalityserum uric acidu-shaped association |
| spellingShingle | Ziqiong Wang Ying Xu Hang Liao Xiaoping Chen Sen He U-shaped association between serum uric acid concentration and mortality in hypertrophic cardiomyopathy patients Upsala Journal of Medical Sciences hypertrophic cardiomyopathy mortality serum uric acid u-shaped association |
| title | U-shaped association between serum uric acid concentration and mortality in hypertrophic cardiomyopathy patients |
| title_full | U-shaped association between serum uric acid concentration and mortality in hypertrophic cardiomyopathy patients |
| title_fullStr | U-shaped association between serum uric acid concentration and mortality in hypertrophic cardiomyopathy patients |
| title_full_unstemmed | U-shaped association between serum uric acid concentration and mortality in hypertrophic cardiomyopathy patients |
| title_short | U-shaped association between serum uric acid concentration and mortality in hypertrophic cardiomyopathy patients |
| title_sort | u shaped association between serum uric acid concentration and mortality in hypertrophic cardiomyopathy patients |
| topic | hypertrophic cardiomyopathy mortality serum uric acid u-shaped association |
| url | http://dx.doi.org/10.1080/03009734.2020.1719245 |
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