Effect of Spontaneous Subarachnoid Hemorrhage on Cerebrospinal Fluid Indicators
The cerebrospinal fluid (CSF) analysis in ruptured aneurysms can be greatly affected by subarachnoid hemorrhage (SAH), making the diagnosis of intracranial infection more difficult after surgery. This study aimed to identify the reference value range of CSF in the pathological state following sponta...
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MDPI AG
2023-05-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/13/5/778 |
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| author | Huichao You Wenqi Li Qianxue Chen |
| author_facet | Huichao You Wenqi Li Qianxue Chen |
| author_sort | Huichao You |
| collection | DOAJ |
| description | The cerebrospinal fluid (CSF) analysis in ruptured aneurysms can be greatly affected by subarachnoid hemorrhage (SAH), making the diagnosis of intracranial infection more difficult after surgery. This study aimed to identify the reference value range of CSF in the pathological state following spontaneous SAH. A retrospective analysis of demographic and CSF data of all spontaneous SAH patients treated between January 2018 and January 2023 was conducted. A total of 101 valid CSF specimen data were collected for analysis. Our results indicate that in 95% of patients after spontaneous SAH, the leukocyte count in CSF was less than 880 × 10<sup>6</sup>/L. Additionally, the proportion of neutrophils, lymphocytes, and monocytes did not exceed 75%, 75%, and 15%, respectively, in 95% of the population. Furthermore, in 95% of the specimens, the concentration of chloride, glucose, and protein was >115 mmol/L, >2.2 mmol/L, and <2.3 g/L, respectively. Compared to the normal reference values, the CSF indexes after spontaneous SAH showed significant changes, especially in the leukocyte count, chloride concentration, and glucose concentration. Using “white blood cell count < 880/mm<sup>3</sup>, glucose > 2.2 mmol/L, chloride > 115” as the reference values for SAH pathological status is more meaningful for reference purposes. |
| first_indexed | 2024-03-11T03:54:17Z |
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| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-11T03:54:17Z |
| publishDate | 2023-05-01 |
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| spelling | doaj.art-edce7cb5de8341f0bb7b62e0fdcc633a2023-11-18T00:42:40ZengMDPI AGBrain Sciences2076-34252023-05-0113577810.3390/brainsci13050778Effect of Spontaneous Subarachnoid Hemorrhage on Cerebrospinal Fluid IndicatorsHuichao You0Wenqi Li1Qianxue Chen2Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaDepartment of Ultrasound, Hubei No. 3 People’s Hospital of Jianghan University, Wuhan 430033, ChinaDepartment of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaThe cerebrospinal fluid (CSF) analysis in ruptured aneurysms can be greatly affected by subarachnoid hemorrhage (SAH), making the diagnosis of intracranial infection more difficult after surgery. This study aimed to identify the reference value range of CSF in the pathological state following spontaneous SAH. A retrospective analysis of demographic and CSF data of all spontaneous SAH patients treated between January 2018 and January 2023 was conducted. A total of 101 valid CSF specimen data were collected for analysis. Our results indicate that in 95% of patients after spontaneous SAH, the leukocyte count in CSF was less than 880 × 10<sup>6</sup>/L. Additionally, the proportion of neutrophils, lymphocytes, and monocytes did not exceed 75%, 75%, and 15%, respectively, in 95% of the population. Furthermore, in 95% of the specimens, the concentration of chloride, glucose, and protein was >115 mmol/L, >2.2 mmol/L, and <2.3 g/L, respectively. Compared to the normal reference values, the CSF indexes after spontaneous SAH showed significant changes, especially in the leukocyte count, chloride concentration, and glucose concentration. Using “white blood cell count < 880/mm<sup>3</sup>, glucose > 2.2 mmol/L, chloride > 115” as the reference values for SAH pathological status is more meaningful for reference purposes.https://www.mdpi.com/2076-3425/13/5/778subarachnoid hemorrhageintracranial infectioncerebrospinal fluid routinecerebrospinal fluid biochemistryleukocyte |
| spellingShingle | Huichao You Wenqi Li Qianxue Chen Effect of Spontaneous Subarachnoid Hemorrhage on Cerebrospinal Fluid Indicators Brain Sciences subarachnoid hemorrhage intracranial infection cerebrospinal fluid routine cerebrospinal fluid biochemistry leukocyte |
| title | Effect of Spontaneous Subarachnoid Hemorrhage on Cerebrospinal Fluid Indicators |
| title_full | Effect of Spontaneous Subarachnoid Hemorrhage on Cerebrospinal Fluid Indicators |
| title_fullStr | Effect of Spontaneous Subarachnoid Hemorrhage on Cerebrospinal Fluid Indicators |
| title_full_unstemmed | Effect of Spontaneous Subarachnoid Hemorrhage on Cerebrospinal Fluid Indicators |
| title_short | Effect of Spontaneous Subarachnoid Hemorrhage on Cerebrospinal Fluid Indicators |
| title_sort | effect of spontaneous subarachnoid hemorrhage on cerebrospinal fluid indicators |
| topic | subarachnoid hemorrhage intracranial infection cerebrospinal fluid routine cerebrospinal fluid biochemistry leukocyte |
| url | https://www.mdpi.com/2076-3425/13/5/778 |
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