Imatinib Mesylate-Loaded Rosin/Cinnamon Oil-Based In Situ Forming Gel against Colorectal Cancer Cells
Localized delivery systems have been typically designed to enhance drug concentration at a target site and minimize systemic drug toxicity. A rosin/cinnamon oil (CO) in situ forming gel (ISG) was developed for the sustainable delivery of imatinib mesylate (IM) against colorectal cancer cells. CO has...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-08-01
|
| Series: | Gels |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2310-2861/8/9/526 |
| _version_ | 1797488149567373312 |
|---|---|
| author | Ei Mon Khaing Torsak Intaraphairot Jongjan Mahadlek Siriporn Okonogi Wiwat Pichayakorn Thawatchai Phaechamud |
| author_facet | Ei Mon Khaing Torsak Intaraphairot Jongjan Mahadlek Siriporn Okonogi Wiwat Pichayakorn Thawatchai Phaechamud |
| author_sort | Ei Mon Khaing |
| collection | DOAJ |
| description | Localized delivery systems have been typically designed to enhance drug concentration at a target site and minimize systemic drug toxicity. A rosin/cinnamon oil (CO) in situ forming gel (ISG) was developed for the sustainable delivery of imatinib mesylate (IM) against colorectal cancer cells. CO has been claimed to express a potent anticancer effect against various cancer cells, as well as a synergistic effect with IM on colorectal cancer cells; however, poor aqueous solubility limits its application. The effect of rosin with the adding CO was assessed on physicochemical properties and in vitro drug release from developed IM-loaded rosin/CO-based ISG. Moreover, in vitro cytotoxicity tests were conducted against two colorectal cancer cells. All formulations exhibited Newtonian flow behavior with viscosity less than 266.9 cP with easier injectability. The adding of CO decreased the hardness and increased the adhesive force of the obtained rosin gel. The gel formation increased over time under microscopic observation. CO-added ISG had a particle-like gel appearance, and it promoted a higher release of IM over a period of 28 days. All tested ISG formulations revealed cytotoxicity against HCT-116 and HT-29 cell lines at different incubation times. Thus, CO-loaded rosin-based ISG can act as a potentially sustainable IM delivery system for chemotherapy against colorectal cancer cells. |
| first_indexed | 2024-03-09T23:58:55Z |
| format | Article |
| id | doaj.art-edd1fa700e844812b8323a0020096fa5 |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-09T23:58:55Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-edd1fa700e844812b8323a0020096fa52023-11-23T16:21:33ZengMDPI AGGels2310-28612022-08-018952610.3390/gels8090526Imatinib Mesylate-Loaded Rosin/Cinnamon Oil-Based In Situ Forming Gel against Colorectal Cancer CellsEi Mon Khaing0Torsak Intaraphairot1Jongjan Mahadlek2Siriporn Okonogi3Wiwat Pichayakorn4Thawatchai Phaechamud5Programme of Pharmaceutical Engineering, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, ThailandDepartment of Biopharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, ThailandNatural Bioactive and Material for Health Promotion and Drug Delivery System Group (NBM), Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, ThailandResearch Center of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Songkhla 90110, ThailandProgramme of Pharmaceutical Engineering, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, ThailandLocalized delivery systems have been typically designed to enhance drug concentration at a target site and minimize systemic drug toxicity. A rosin/cinnamon oil (CO) in situ forming gel (ISG) was developed for the sustainable delivery of imatinib mesylate (IM) against colorectal cancer cells. CO has been claimed to express a potent anticancer effect against various cancer cells, as well as a synergistic effect with IM on colorectal cancer cells; however, poor aqueous solubility limits its application. The effect of rosin with the adding CO was assessed on physicochemical properties and in vitro drug release from developed IM-loaded rosin/CO-based ISG. Moreover, in vitro cytotoxicity tests were conducted against two colorectal cancer cells. All formulations exhibited Newtonian flow behavior with viscosity less than 266.9 cP with easier injectability. The adding of CO decreased the hardness and increased the adhesive force of the obtained rosin gel. The gel formation increased over time under microscopic observation. CO-added ISG had a particle-like gel appearance, and it promoted a higher release of IM over a period of 28 days. All tested ISG formulations revealed cytotoxicity against HCT-116 and HT-29 cell lines at different incubation times. Thus, CO-loaded rosin-based ISG can act as a potentially sustainable IM delivery system for chemotherapy against colorectal cancer cells.https://www.mdpi.com/2310-2861/8/9/526rosinin situ forming gelcinnamon oilimatinib mesylatecolorectal cancer |
| spellingShingle | Ei Mon Khaing Torsak Intaraphairot Jongjan Mahadlek Siriporn Okonogi Wiwat Pichayakorn Thawatchai Phaechamud Imatinib Mesylate-Loaded Rosin/Cinnamon Oil-Based In Situ Forming Gel against Colorectal Cancer Cells Gels rosin in situ forming gel cinnamon oil imatinib mesylate colorectal cancer |
| title | Imatinib Mesylate-Loaded Rosin/Cinnamon Oil-Based In Situ Forming Gel against Colorectal Cancer Cells |
| title_full | Imatinib Mesylate-Loaded Rosin/Cinnamon Oil-Based In Situ Forming Gel against Colorectal Cancer Cells |
| title_fullStr | Imatinib Mesylate-Loaded Rosin/Cinnamon Oil-Based In Situ Forming Gel against Colorectal Cancer Cells |
| title_full_unstemmed | Imatinib Mesylate-Loaded Rosin/Cinnamon Oil-Based In Situ Forming Gel against Colorectal Cancer Cells |
| title_short | Imatinib Mesylate-Loaded Rosin/Cinnamon Oil-Based In Situ Forming Gel against Colorectal Cancer Cells |
| title_sort | imatinib mesylate loaded rosin cinnamon oil based in situ forming gel against colorectal cancer cells |
| topic | rosin in situ forming gel cinnamon oil imatinib mesylate colorectal cancer |
| url | https://www.mdpi.com/2310-2861/8/9/526 |
| work_keys_str_mv | AT eimonkhaing imatinibmesylateloadedrosincinnamonoilbasedinsituforminggelagainstcolorectalcancercells AT torsakintaraphairot imatinibmesylateloadedrosincinnamonoilbasedinsituforminggelagainstcolorectalcancercells AT jongjanmahadlek imatinibmesylateloadedrosincinnamonoilbasedinsituforminggelagainstcolorectalcancercells AT siripornokonogi imatinibmesylateloadedrosincinnamonoilbasedinsituforminggelagainstcolorectalcancercells AT wiwatpichayakorn imatinibmesylateloadedrosincinnamonoilbasedinsituforminggelagainstcolorectalcancercells AT thawatchaiphaechamud imatinibmesylateloadedrosincinnamonoilbasedinsituforminggelagainstcolorectalcancercells |