Use of admission serum neutrophil gelatinase-associated lipocalin (NGAL) concentrations as a marker of sepsis and outcome in neonatal foals.
<h4>Background</h4>Equine neonatal sepsis can be challenging to diagnose and prognosticate. Neutrophil gelatinase-associated lipocalin (NGAL), a new marker of renal damage and inflammation, can potentially be helpful.<h4>Objectives</h4>To evaluate NGAL in neonatal foals with...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2023-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0285819 |
| _version_ | 1797802077174366208 |
|---|---|
| author | Malene Laurberg Claude Saegerman Stine Jacobsen Lise C Berg Sigrid Hyldahl Laursen Emma Hoeberg Elaine Alexandra Sånge Gaby van Galen |
| author_facet | Malene Laurberg Claude Saegerman Stine Jacobsen Lise C Berg Sigrid Hyldahl Laursen Emma Hoeberg Elaine Alexandra Sånge Gaby van Galen |
| author_sort | Malene Laurberg |
| collection | DOAJ |
| description | <h4>Background</h4>Equine neonatal sepsis can be challenging to diagnose and prognosticate. Neutrophil gelatinase-associated lipocalin (NGAL), a new marker of renal damage and inflammation, can potentially be helpful.<h4>Objectives</h4>To evaluate NGAL in neonatal foals with sepsis, and assess its relation to outcome.<h4>Animals</h4>Foals ≤ 14 days, with admission blood analysis and stored serum.<h4>Methods</h4>NGAL was measured on stored serum from 91 foals. Foals were scored for sepsis and survival and categorized according to sepsis status (septic, sick non-septic, healthy, and uncertain sepsis status) and outcome groups (survivors and non-survivors). The septic foals were further sub-categorized according to severity (normal sepsis, severe sepsis and septic shock). A Kruskal-Wallis test was used to compare serum NGAL concentrations in survivors and non-survivors, in the sepsis status groups, and in the sepsis severity groups. Optimal cut-off values for serum NGAL concentrations to diagnose sepsis and outcome were determined with receiver operating characteristic (ROC) curves. NGAL was compared to creatinine and SAA.<h4>Results</h4>Median serum NGAL concentrations were significantly higher in septic than non-septic foals. However, serum NGAL concentrations did not differ between sepsis severity subgroups. Serum NGAL concentrations were significantly lower in survivors than in non-survivors. Optimal cut-off values of serum NGAL concentrations were 455 μg/L (sensitivity 71.4%, specificity 100%) and 1104 μg/L (sensitivity 39.3%, specificity 95.2%) for predicting sepsis and non-survival, respectively. NGAL correlated to SAA, but not to creatinine. NGAL performed similarly to SAA to diagnose sepsis.<h4>Conclusion</h4>Serum NGAL concentrations may be useful for diagnosing sepsis and predicting outcome. |
| first_indexed | 2024-03-13T05:00:13Z |
| format | Article |
| id | doaj.art-edd32d4f95d0418ebe4894ab995cbfac |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-03-13T05:00:13Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-edd32d4f95d0418ebe4894ab995cbfac2023-06-17T05:31:18ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01185e028581910.1371/journal.pone.0285819Use of admission serum neutrophil gelatinase-associated lipocalin (NGAL) concentrations as a marker of sepsis and outcome in neonatal foals.Malene LaurbergClaude SaegermanStine JacobsenLise C BergSigrid Hyldahl LaursenEmma HoebergElaine Alexandra SångeGaby van Galen<h4>Background</h4>Equine neonatal sepsis can be challenging to diagnose and prognosticate. Neutrophil gelatinase-associated lipocalin (NGAL), a new marker of renal damage and inflammation, can potentially be helpful.<h4>Objectives</h4>To evaluate NGAL in neonatal foals with sepsis, and assess its relation to outcome.<h4>Animals</h4>Foals ≤ 14 days, with admission blood analysis and stored serum.<h4>Methods</h4>NGAL was measured on stored serum from 91 foals. Foals were scored for sepsis and survival and categorized according to sepsis status (septic, sick non-septic, healthy, and uncertain sepsis status) and outcome groups (survivors and non-survivors). The septic foals were further sub-categorized according to severity (normal sepsis, severe sepsis and septic shock). A Kruskal-Wallis test was used to compare serum NGAL concentrations in survivors and non-survivors, in the sepsis status groups, and in the sepsis severity groups. Optimal cut-off values for serum NGAL concentrations to diagnose sepsis and outcome were determined with receiver operating characteristic (ROC) curves. NGAL was compared to creatinine and SAA.<h4>Results</h4>Median serum NGAL concentrations were significantly higher in septic than non-septic foals. However, serum NGAL concentrations did not differ between sepsis severity subgroups. Serum NGAL concentrations were significantly lower in survivors than in non-survivors. Optimal cut-off values of serum NGAL concentrations were 455 μg/L (sensitivity 71.4%, specificity 100%) and 1104 μg/L (sensitivity 39.3%, specificity 95.2%) for predicting sepsis and non-survival, respectively. NGAL correlated to SAA, but not to creatinine. NGAL performed similarly to SAA to diagnose sepsis.<h4>Conclusion</h4>Serum NGAL concentrations may be useful for diagnosing sepsis and predicting outcome.https://doi.org/10.1371/journal.pone.0285819 |
| spellingShingle | Malene Laurberg Claude Saegerman Stine Jacobsen Lise C Berg Sigrid Hyldahl Laursen Emma Hoeberg Elaine Alexandra Sånge Gaby van Galen Use of admission serum neutrophil gelatinase-associated lipocalin (NGAL) concentrations as a marker of sepsis and outcome in neonatal foals. PLoS ONE |
| title | Use of admission serum neutrophil gelatinase-associated lipocalin (NGAL) concentrations as a marker of sepsis and outcome in neonatal foals. |
| title_full | Use of admission serum neutrophil gelatinase-associated lipocalin (NGAL) concentrations as a marker of sepsis and outcome in neonatal foals. |
| title_fullStr | Use of admission serum neutrophil gelatinase-associated lipocalin (NGAL) concentrations as a marker of sepsis and outcome in neonatal foals. |
| title_full_unstemmed | Use of admission serum neutrophil gelatinase-associated lipocalin (NGAL) concentrations as a marker of sepsis and outcome in neonatal foals. |
| title_short | Use of admission serum neutrophil gelatinase-associated lipocalin (NGAL) concentrations as a marker of sepsis and outcome in neonatal foals. |
| title_sort | use of admission serum neutrophil gelatinase associated lipocalin ngal concentrations as a marker of sepsis and outcome in neonatal foals |
| url | https://doi.org/10.1371/journal.pone.0285819 |
| work_keys_str_mv | AT malenelaurberg useofadmissionserumneutrophilgelatinaseassociatedlipocalinngalconcentrationsasamarkerofsepsisandoutcomeinneonatalfoals AT claudesaegerman useofadmissionserumneutrophilgelatinaseassociatedlipocalinngalconcentrationsasamarkerofsepsisandoutcomeinneonatalfoals AT stinejacobsen useofadmissionserumneutrophilgelatinaseassociatedlipocalinngalconcentrationsasamarkerofsepsisandoutcomeinneonatalfoals AT lisecberg useofadmissionserumneutrophilgelatinaseassociatedlipocalinngalconcentrationsasamarkerofsepsisandoutcomeinneonatalfoals AT sigridhyldahllaursen useofadmissionserumneutrophilgelatinaseassociatedlipocalinngalconcentrationsasamarkerofsepsisandoutcomeinneonatalfoals AT emmahoeberg useofadmissionserumneutrophilgelatinaseassociatedlipocalinngalconcentrationsasamarkerofsepsisandoutcomeinneonatalfoals AT elainealexandrasange useofadmissionserumneutrophilgelatinaseassociatedlipocalinngalconcentrationsasamarkerofsepsisandoutcomeinneonatalfoals AT gabyvangalen useofadmissionserumneutrophilgelatinaseassociatedlipocalinngalconcentrationsasamarkerofsepsisandoutcomeinneonatalfoals |