Genetics in non-alcoholic fatty liver disease: The role of risk alleles through the lens of immune response
The knowledge on the genetic component of non-alcoholic fatty liver disease (NAFLD) has grown exponentially over the last 10 to 15 years. This review summarizes the current evidence and the latest developments in the genetics of NAFLD and non-alcoholic steatohepatitis (NASH) from the immune system’s...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Korean Association for the Study of the Liver
2023-02-01
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| Series: | Clinical and Molecular Hepatology |
| Subjects: | |
| Online Access: | http://e-cmh.org/upload/pdf/cmh-2022-0318.pdf |
| _version_ | 1797871546422788096 |
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| author | Silvia Sookoian Carlos J. Pirola |
| author_facet | Silvia Sookoian Carlos J. Pirola |
| author_sort | Silvia Sookoian |
| collection | DOAJ |
| description | The knowledge on the genetic component of non-alcoholic fatty liver disease (NAFLD) has grown exponentially over the last 10 to 15 years. This review summarizes the current evidence and the latest developments in the genetics of NAFLD and non-alcoholic steatohepatitis (NASH) from the immune system’s perspective. Activation of innate and or adaptive immune response is an essential driver of NAFLD disease severity and progression. Lipid and immune pathways are crucial in the pathophysiology of NAFLD and NASH. Here, we highlight novel applications of genomic techniques, including single-cell sequencing and the genetics of gene expression, to elucidate the potential involvement of NAFLD/NASH-risk alleles in modulating immune system cells. Together, our focus is to provide an overview of the potential involvement of the NAFLD/NASH-related risk variants in mediating the immune-driven liver disease severity and diverse systemic pleiotropic effects. |
| first_indexed | 2024-04-10T00:45:34Z |
| format | Article |
| id | doaj.art-edd4c5938b8d4e778f994bf7671fe69e |
| institution | Directory Open Access Journal |
| issn | 2287-2728 2287-285X |
| language | English |
| last_indexed | 2024-04-10T00:45:34Z |
| publishDate | 2023-02-01 |
| publisher | Korean Association for the Study of the Liver |
| record_format | Article |
| series | Clinical and Molecular Hepatology |
| spelling | doaj.art-edd4c5938b8d4e778f994bf7671fe69e2023-03-14T01:46:51ZengKorean Association for the Study of the LiverClinical and Molecular Hepatology2287-27282287-285X2023-02-0129SupplS184S19510.3350/cmh.2022.03181738Genetics in non-alcoholic fatty liver disease: The role of risk alleles through the lens of immune responseSilvia Sookoian0Carlos J. Pirola1 Clinical and Molecular Hepatology. Centro de Altos Estudios en Ciencias Humanas y de la Salud (CAECIHS), Universidad Abierta Interamericana, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina Systems Biology of Complex Diseases, Centro de Altos Estudios en Ciencias Humanas y de la Salud (CAECIHS), Universidad Abierta Interamericana, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, ArgentinaThe knowledge on the genetic component of non-alcoholic fatty liver disease (NAFLD) has grown exponentially over the last 10 to 15 years. This review summarizes the current evidence and the latest developments in the genetics of NAFLD and non-alcoholic steatohepatitis (NASH) from the immune system’s perspective. Activation of innate and or adaptive immune response is an essential driver of NAFLD disease severity and progression. Lipid and immune pathways are crucial in the pathophysiology of NAFLD and NASH. Here, we highlight novel applications of genomic techniques, including single-cell sequencing and the genetics of gene expression, to elucidate the potential involvement of NAFLD/NASH-risk alleles in modulating immune system cells. Together, our focus is to provide an overview of the potential involvement of the NAFLD/NASH-related risk variants in mediating the immune-driven liver disease severity and diverse systemic pleiotropic effects.http://e-cmh.org/upload/pdf/cmh-2022-0318.pdfnonalcoholic steatohepatitisgeneticspnpla3hsd17b13immune system |
| spellingShingle | Silvia Sookoian Carlos J. Pirola Genetics in non-alcoholic fatty liver disease: The role of risk alleles through the lens of immune response Clinical and Molecular Hepatology nonalcoholic steatohepatitis genetics pnpla3 hsd17b13 immune system |
| title | Genetics in non-alcoholic fatty liver disease: The role of risk alleles through the lens of immune response |
| title_full | Genetics in non-alcoholic fatty liver disease: The role of risk alleles through the lens of immune response |
| title_fullStr | Genetics in non-alcoholic fatty liver disease: The role of risk alleles through the lens of immune response |
| title_full_unstemmed | Genetics in non-alcoholic fatty liver disease: The role of risk alleles through the lens of immune response |
| title_short | Genetics in non-alcoholic fatty liver disease: The role of risk alleles through the lens of immune response |
| title_sort | genetics in non alcoholic fatty liver disease the role of risk alleles through the lens of immune response |
| topic | nonalcoholic steatohepatitis genetics pnpla3 hsd17b13 immune system |
| url | http://e-cmh.org/upload/pdf/cmh-2022-0318.pdf |
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