Is sclerostin antibody an effective agent for alveolar bone regeneration in animal models? A scoping review
Objectives The use of Sclerostin Antibody(Scl-Ab) as a bone anabolic agent has shown significant benefit in bone disorders in preclinical animal models and human clinical trials. Currently available evidence on the use of Scl-Ab in alveolar bone regeneration is limited to animal studies and hence th...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Cumhuriyet University
2022-12-01
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| Series: | Cumhuriyet Dental Journal |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/tr/download/article-file/2403031 |
| _version_ | 1797703824121528320 |
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| author | Venkitachalam Ramanarayanan Jothi M Varghese Madhurya N Kedlaya Sunaina Banu Lakshmi Puzhankara |
| author_facet | Venkitachalam Ramanarayanan Jothi M Varghese Madhurya N Kedlaya Sunaina Banu Lakshmi Puzhankara |
| author_sort | Venkitachalam Ramanarayanan |
| collection | DOAJ |
| description | Objectives
The use of Sclerostin Antibody(Scl-Ab) as a bone anabolic agent has shown significant benefit in bone disorders in preclinical animal models and human clinical trials. Currently available evidence on the use of Scl-Ab in alveolar bone regeneration is limited to animal studies and hence this scoping review encompasses the animal studies conducted to ascertain the effectiveness of Scl-Ab on alveolar bone regeneration.
Materials and methods
The search strategy was aimed to locate published animal studies in which the treatment arm includes Sclerostin antibody administration for alveolar bone preservation or regeneration. The search terms used were (((Animal model) OR Rodent) AND Alveolar bone defect) AND Anti sclerostin antibody) OR Sclerostin antibody) AND Alveolar bone regeneration) OR Bone regeneration) AND Bone fill.
Results
Of the 559 results from Medline/PubMed, Scopus, Web of Science, Google scholar and additional articles from the references, six were included in the review. Scl-Ab was found to be effective in improving the bone quality and quantity. It was also observed that Scl-Ab was useful in reduced bone density associated with diseases and conditiona affecting osteoblast activity.
Conclusion
The review concluded that Scl-Ab promotes alveolar bone augmentation and improves bone quality without surgical interventions. |
| first_indexed | 2024-03-12T05:10:11Z |
| format | Article |
| id | doaj.art-edd5aa034f39480e93e0de2b4fcae301 |
| institution | Directory Open Access Journal |
| issn | 1302-5805 2146-2852 |
| language | English |
| last_indexed | 2024-03-12T05:10:11Z |
| publishDate | 2022-12-01 |
| publisher | Cumhuriyet University |
| record_format | Article |
| series | Cumhuriyet Dental Journal |
| spelling | doaj.art-edd5aa034f39480e93e0de2b4fcae3012023-09-03T08:41:52ZengCumhuriyet UniversityCumhuriyet Dental Journal1302-58052146-28522022-12-0125434134910.7126/cumudj.11104132057Is sclerostin antibody an effective agent for alveolar bone regeneration in animal models? A scoping reviewVenkitachalam Ramanarayanan0Jothi M Varghese1Madhurya N Kedlaya2Sunaina Banu3Lakshmi Puzhankara4Amrita School of Dentistry, Amrita VishwavidyapeethamManipal College of Dental Sciences, Manipal Academy of Higher EducationManipal College of Dental Sciences, Manipal Academy of Higher EducationManipal College of Dental Sciences, Manipal Academy of Higher EducationManipal College of Dental Sciences, Manipal Academy of Higher EducationObjectives The use of Sclerostin Antibody(Scl-Ab) as a bone anabolic agent has shown significant benefit in bone disorders in preclinical animal models and human clinical trials. Currently available evidence on the use of Scl-Ab in alveolar bone regeneration is limited to animal studies and hence this scoping review encompasses the animal studies conducted to ascertain the effectiveness of Scl-Ab on alveolar bone regeneration. Materials and methods The search strategy was aimed to locate published animal studies in which the treatment arm includes Sclerostin antibody administration for alveolar bone preservation or regeneration. The search terms used were (((Animal model) OR Rodent) AND Alveolar bone defect) AND Anti sclerostin antibody) OR Sclerostin antibody) AND Alveolar bone regeneration) OR Bone regeneration) AND Bone fill. Results Of the 559 results from Medline/PubMed, Scopus, Web of Science, Google scholar and additional articles from the references, six were included in the review. Scl-Ab was found to be effective in improving the bone quality and quantity. It was also observed that Scl-Ab was useful in reduced bone density associated with diseases and conditiona affecting osteoblast activity. Conclusion The review concluded that Scl-Ab promotes alveolar bone augmentation and improves bone quality without surgical interventions.https://dergipark.org.tr/tr/download/article-file/2403031alveolar boneanimal modelpreclinical modelregenerationsclerostinsclerostin antibody |
| spellingShingle | Venkitachalam Ramanarayanan Jothi M Varghese Madhurya N Kedlaya Sunaina Banu Lakshmi Puzhankara Is sclerostin antibody an effective agent for alveolar bone regeneration in animal models? A scoping review Cumhuriyet Dental Journal alveolar bone animal model preclinical model regeneration sclerostin sclerostin antibody |
| title | Is sclerostin antibody an effective agent for alveolar bone regeneration in animal models? A scoping review |
| title_full | Is sclerostin antibody an effective agent for alveolar bone regeneration in animal models? A scoping review |
| title_fullStr | Is sclerostin antibody an effective agent for alveolar bone regeneration in animal models? A scoping review |
| title_full_unstemmed | Is sclerostin antibody an effective agent for alveolar bone regeneration in animal models? A scoping review |
| title_short | Is sclerostin antibody an effective agent for alveolar bone regeneration in animal models? A scoping review |
| title_sort | is sclerostin antibody an effective agent for alveolar bone regeneration in animal models a scoping review |
| topic | alveolar bone animal model preclinical model regeneration sclerostin sclerostin antibody |
| url | https://dergipark.org.tr/tr/download/article-file/2403031 |
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