Concise One-Pot Multicomponent Reaction Approach to Mono­fluo­rinated Spiro-pyrazole-pyridine Derivatives without Additional Catalyst

Concise One-Pot Multicomponent Reaction Approach to Mono­fluo­rinated Spiro-pyrazole-pyridine Derivatives without Additional Catalyst

Monofluorinated bis-heterocyclic spirocycles: functionalized ethyl 9-fluoro-8-methyl-1,4-dioxo-2,3,6,10-tetraphenyl-2,3,7-triazaspiro[4.5]dec-7-ene-9-carboxylate derivatives were efficiently synthesized from readily available 1,2-diphenylpyrazolidine-3,5-dione, ethyl 2-fluoroacetoacetate, aromatic a...

Full description

Bibliographic Details
Main Authors: Ying Liu, Yiping Zhang, Yingkai Zhou, Min Zhang, Hongmei Deng, Liping Song
Format: Article
Language:English
Published: Georg Thieme Verlag KG 2022-08-01
Series:SynOpen
Subjects:
one-pot multicomponent reaction
ethyl 2-fluoroacetoacetate
1,2-diphenylpyrazolidine-3,5-dione
fluorinated spiro-pyrazole-pyridine derivatives
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/a-1866-4653
Description
Summary:Monofluorinated bis-heterocyclic spirocycles: functionalized ethyl 9-fluoro-8-methyl-1,4-dioxo-2,3,6,10-tetraphenyl-2,3,7-triazaspiro[4.5]dec-7-ene-9-carboxylate derivatives were efficiently synthesized from readily available 1,2-diphenylpyrazolidine-3,5-dione, ethyl 2-fluoroacetoacetate, aromatic aldehydes, and ammonium acetate via one-pot four-component reactions in the absence of additional catalyst. In the protocols, ammonium acetate serves not only as the fourth component but also as the catalyst.
ISSN:2509-9396

Similar Items