Concise One-Pot Multicomponent Reaction Approach to Monofluorinated Spiro-pyrazole-pyridine Derivatives without Additional Catalyst
Monofluorinated bis-heterocyclic spirocycles: functionalized ethyl 9-fluoro-8-methyl-1,4-dioxo-2,3,6,10-tetraphenyl-2,3,7-triazaspiro[4.5]dec-7-ene-9-carboxylate derivatives were efficiently synthesized from readily available 1,2-diphenylpyrazolidine-3,5-dione, ethyl 2-fluoroacetoacetate, aromatic a...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Georg Thieme Verlag KG
2022-08-01
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| Series: | SynOpen |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/a-1866-4653 |
| _version_ | 1818537665344045056 |
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| author | Ying Liu Yiping Zhang Yingkai Zhou Min Zhang Hongmei Deng Liping Song |
| author_facet | Ying Liu Yiping Zhang Yingkai Zhou Min Zhang Hongmei Deng Liping Song |
| author_sort | Ying Liu |
| collection | DOAJ |
| description | Monofluorinated bis-heterocyclic spirocycles: functionalized ethyl 9-fluoro-8-methyl-1,4-dioxo-2,3,6,10-tetraphenyl-2,3,7-triazaspiro[4.5]dec-7-ene-9-carboxylate derivatives were efficiently synthesized from readily available 1,2-diphenylpyrazolidine-3,5-dione, ethyl 2-fluoroacetoacetate, aromatic aldehydes, and ammonium acetate via one-pot four-component reactions in the absence of additional catalyst. In the protocols, ammonium acetate serves not only as the fourth component but also as the catalyst. |
| first_indexed | 2024-12-11T18:53:41Z |
| format | Article |
| id | doaj.art-edd71e6f36db4d56943f1186862d2b02 |
| institution | Directory Open Access Journal |
| issn | 2509-9396 |
| language | English |
| last_indexed | 2024-12-11T18:53:41Z |
| publishDate | 2022-08-01 |
| publisher | Georg Thieme Verlag KG |
| record_format | Article |
| series | SynOpen |
| spelling | doaj.art-edd71e6f36db4d56943f1186862d2b022022-12-22T00:54:13ZengGeorg Thieme Verlag KGSynOpen2509-93962022-08-01060316417210.1055/a-1866-4653Concise One-Pot Multicomponent Reaction Approach to Monofluorinated Spiro-pyrazole-pyridine Derivatives without Additional CatalystYing Liu0Yiping Zhang1Yingkai Zhou2Min Zhang3Hongmei Deng4Liping Song5Department of Chemistry, School of Science, Shanghai UniversityDepartment of Chemistry, School of Science, Shanghai UniversityDepartment of Chemistry, School of Science, Shanghai UniversityDepartment of Chemistry, School of Science, Shanghai UniversityLaboratory for Microstructures, Shanghai UniversityDepartment of Chemistry, School of Science, Shanghai UniversityMonofluorinated bis-heterocyclic spirocycles: functionalized ethyl 9-fluoro-8-methyl-1,4-dioxo-2,3,6,10-tetraphenyl-2,3,7-triazaspiro[4.5]dec-7-ene-9-carboxylate derivatives were efficiently synthesized from readily available 1,2-diphenylpyrazolidine-3,5-dione, ethyl 2-fluoroacetoacetate, aromatic aldehydes, and ammonium acetate via one-pot four-component reactions in the absence of additional catalyst. In the protocols, ammonium acetate serves not only as the fourth component but also as the catalyst.http://www.thieme-connect.de/DOI/DOI?10.1055/a-1866-4653one-pot multicomponent reactionethyl 2-fluoroacetoacetate1,2-diphenylpyrazolidine-3,5-dionefluorinated spiro-pyrazole-pyridine derivatives |
| spellingShingle | Ying Liu Yiping Zhang Yingkai Zhou Min Zhang Hongmei Deng Liping Song Concise One-Pot Multicomponent Reaction Approach to Monofluorinated Spiro-pyrazole-pyridine Derivatives without Additional Catalyst SynOpen one-pot multicomponent reaction ethyl 2-fluoroacetoacetate 1,2-diphenylpyrazolidine-3,5-dione fluorinated spiro-pyrazole-pyridine derivatives |
| title | Concise One-Pot Multicomponent Reaction Approach to Monofluorinated Spiro-pyrazole-pyridine Derivatives without Additional Catalyst |
| title_full | Concise One-Pot Multicomponent Reaction Approach to Monofluorinated Spiro-pyrazole-pyridine Derivatives without Additional Catalyst |
| title_fullStr | Concise One-Pot Multicomponent Reaction Approach to Monofluorinated Spiro-pyrazole-pyridine Derivatives without Additional Catalyst |
| title_full_unstemmed | Concise One-Pot Multicomponent Reaction Approach to Monofluorinated Spiro-pyrazole-pyridine Derivatives without Additional Catalyst |
| title_short | Concise One-Pot Multicomponent Reaction Approach to Monofluorinated Spiro-pyrazole-pyridine Derivatives without Additional Catalyst |
| title_sort | concise one pot multicomponent reaction approach to mono fluo rinated spiro pyrazole pyridine derivatives without additional catalyst |
| topic | one-pot multicomponent reaction ethyl 2-fluoroacetoacetate 1,2-diphenylpyrazolidine-3,5-dione fluorinated spiro-pyrazole-pyridine derivatives |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/a-1866-4653 |
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