Functional Inhibition of Valosin-Containing Protein Induces Cardiac Dilation and Dysfunction in a New Dominant-Negative Transgenic Mouse Model

Functional Inhibition of Valosin-Containing Protein Induces Cardiac Dilation and Dysfunction in a New Dominant-Negative Transgenic Mouse Model

Valosin-containing protein (VCP) was found to play a vital protective role against cardiac stresses. Genetic mutations of VCP are associated with human dilated cardiomyopathy. However, the essential role of VCP in the heart during the physiological condition remains unknown since the VCP knockout in...

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Bibliographic Details
Main Authors: Xiaonan Sun, Ning Zhou, Ben Ma, Wenqian Wu, Shaunrick Stoll, Lo Lai, Gangjian Qin, Hongyu Qiu
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cells
Subjects:
valosin-containing protein
dilated cardiomyopathy
nuclear translocation
co-factor interaction
P47
nuclear protein localization protein 4
Online Access:https://www.mdpi.com/2073-4409/10/11/2891

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