Lack of Association between Enamel Gene Variants and Dental Caries in Adults
Objectives: Studies report that gene polymorphisms associated with mineralization may change the structure of enamel and create a predisposition for developing dental caries. The aim of the study was to evaluate the VDR and TFIP11 gene variants in adults with caries experience and to investigate the...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Cumhuriyet University
2020-06-01
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| Series: | Cumhuriyet Dental Journal |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/tr/download/article-file/1174448 |
| Summary: | Objectives: Studies report that gene polymorphisms associated with mineralization
may change the structure of enamel and create a predisposition for developing
dental caries. The aim of the study was to evaluate the VDR and TFIP11 gene
variants in adults with caries experience and to investigate their interactions
with the environmental factors. Materials
and Methods: A total of 160 individuals at the age of 24-40 years were
included in the study and they were assigned to two groups according to
decayed-missing-filled teeth index (DMFT); namely the low caries experience
(LCE, DMFT≤4) and high caries experience (HCE, DMFT> 9.13). DNA was isolated from buccal swab samples to
genotype the VDR (TaqI; rs731236) and
TFIP11 (rs5997096) gene variants. The
real-time PCR was used for genotyping. The frequency of tooth brushing, carbohydrate
intake, smoking, and the dental plaques were evaluated as environmental risk
factors. Results: Between the caries
groups and the distribution of the genotypes and alleles of the VDR rs731236 and TFIP11 rs5997096 gene variants were not statistically different.
There was also no significant difference when homozygous, heterozygous,
dominant, and recessive models were evaluated for the two variants. The
frequency of tooth brushing was significantly higher in the LCE group.
According to the regression analysis; the amount of plaque explained the high
caries experience at a rate of 51.4%. Conclusions:
The study findings indicated that common
variants in the VDR and TFIP11 genes were not associated with high caries
experiences in Turkish adults. |
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| ISSN: | 1302-5805 2146-2852 |