<b>N-6 substituted deoxygenated derivatives of L-like 5'-noraristeromycin</b>
Several N-6 substituted derivatives (<b>4</b>-<b>11</b>) of (+)-4'-deoxy-5'-noraristeromycin (<b>2</b>) and its unsaturated counterpart (<b>3</b>) have been prepared. The derivatives are designed to systematically vary the hydrophobic/hydroph...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Chemical Society of Ethiopia
2010-12-01
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| Series: | Bulletin of the Chemical Society of Ethiopia |
| Subjects: | |
| Online Access: | http://ajol.info/index.php/bcse/article/view/60692 |
| _version_ | 1818262171247706112 |
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| author | Henry Yu Tesfaye Serbessa |
| author_facet | Henry Yu Tesfaye Serbessa |
| author_sort | Henry Yu |
| collection | DOAJ |
| description | Several N-6 substituted derivatives (<b>4</b>-<b>11</b>) of (+)-4'-deoxy-5'-noraristeromycin (<b>2</b>) and its unsaturated counterpart (<b>3</b>) have been prepared. The derivatives are designed to systematically vary the hydrophobic/hydrophilic balance of the lead compounds. These compounds were evaluated against a large number of viruses but no significant antiviral activity was observed. Also, no cytotoxicity to host cells was found. |
| first_indexed | 2024-12-12T18:58:53Z |
| format | Article |
| id | doaj.art-edd8062c90c74d6ca6a9eb535ed67d33 |
| institution | Directory Open Access Journal |
| issn | 1011-3924 1726-801X |
| language | English |
| last_indexed | 2024-12-12T18:58:53Z |
| publishDate | 2010-12-01 |
| publisher | Chemical Society of Ethiopia |
| record_format | Article |
| series | Bulletin of the Chemical Society of Ethiopia |
| spelling | doaj.art-edd8062c90c74d6ca6a9eb535ed67d332022-12-22T00:15:10ZengChemical Society of EthiopiaBulletin of the Chemical Society of Ethiopia1011-39241726-801X2010-12-01243439446<b>N-6 substituted deoxygenated derivatives of L-like 5'-noraristeromycin</b>Henry YuTesfaye SerbessaSeveral N-6 substituted derivatives (<b>4</b>-<b>11</b>) of (+)-4'-deoxy-5'-noraristeromycin (<b>2</b>) and its unsaturated counterpart (<b>3</b>) have been prepared. The derivatives are designed to systematically vary the hydrophobic/hydrophilic balance of the lead compounds. These compounds were evaluated against a large number of viruses but no significant antiviral activity was observed. Also, no cytotoxicity to host cells was found.http://ajol.info/index.php/bcse/article/view/60692L-likeCarbocyclic nucleosidesHBV |
| spellingShingle | Henry Yu Tesfaye Serbessa <b>N-6 substituted deoxygenated derivatives of L-like 5'-noraristeromycin</b> Bulletin of the Chemical Society of Ethiopia L-like Carbocyclic nucleosides HBV |
| title | <b>N-6 substituted deoxygenated derivatives of L-like 5'-noraristeromycin</b> |
| title_full | <b>N-6 substituted deoxygenated derivatives of L-like 5'-noraristeromycin</b> |
| title_fullStr | <b>N-6 substituted deoxygenated derivatives of L-like 5'-noraristeromycin</b> |
| title_full_unstemmed | <b>N-6 substituted deoxygenated derivatives of L-like 5'-noraristeromycin</b> |
| title_short | <b>N-6 substituted deoxygenated derivatives of L-like 5'-noraristeromycin</b> |
| title_sort | b n 6 substituted deoxygenated derivatives of l like 5 noraristeromycin b |
| topic | L-like Carbocyclic nucleosides HBV |
| url | http://ajol.info/index.php/bcse/article/view/60692 |
| work_keys_str_mv | AT henryyu bn6substituteddeoxygenatedderivativesofllike5noraristeromycinb AT tesfayeserbessa bn6substituteddeoxygenatedderivativesofllike5noraristeromycinb |