Embryogenesis of bladder exstrophy: A new hypothesis
<b>Aims and Objective:</b> To postulate a hypothesis to explain the embryogenesis of exstrophy bladder based on our clinical observations. <b> Materials and Methods:</b> In 27 cases of exstrophy, we measured the distance between the lowermost inguinal skin crease to the roo...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2008-01-01
|
| Series: | Journal of Indian Association of Pediatric Surgeons |
| Subjects: | |
| Online Access: | http://www.jiaps.com/article.asp?issn=0971-9261;year=2008;volume=13;issue=2;spage=57;epage=60;aulast=Kulkarni |
| _version_ | 1818262171519287296 |
|---|---|
| author | Kulkarni Bharati Chaudhari Navin |
| author_facet | Kulkarni Bharati Chaudhari Navin |
| author_sort | Kulkarni Bharati |
| collection | DOAJ |
| description | <b>Aims and Objective:</b> To postulate a hypothesis to explain the embryogenesis of exstrophy bladder based on our clinical observations. <b> Materials and Methods:</b> In 27 cases of exstrophy, we measured the distance between the lowermost inguinal skin crease to the root of the penis (clitoris) (B) and the distance between the penis (clitoris) and the scrotum (labia majora) (C). These were compared with age, height and XP distance (distance between xiphisternum and symphysis pubis) matched control group of normal children. The distance between the lowermost inguinal skin crease and the penis (clitoris) (A) was measured in control group. <b> Results:</b> The observation was A = B + C. This implies that in exstrophy bladder, the position of the penis (clitoris) has moved cephalad from the lower border of A to the junction of B and C. <b> Conclusion:</b> Based on the observations, we postulate that abnormal origin of genital tubercle may be the cause of exstrophy bladder. The abnormal origin of primordia of the genital tubercle in more cephalad direction than normal causes wedge effect, which will interfere with the medial migration of the mesoderm as well as the midline approximation of mesodermal structures in the lower abdominal wall, thereby resulting in the exstrophy of bladder. |
| first_indexed | 2024-12-12T18:58:53Z |
| format | Article |
| id | doaj.art-edd8180046174b3893c81e0640ea719f |
| institution | Directory Open Access Journal |
| issn | 0971-9261 1998-3891 |
| language | English |
| last_indexed | 2024-12-12T18:58:53Z |
| publishDate | 2008-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Indian Association of Pediatric Surgeons |
| spelling | doaj.art-edd8180046174b3893c81e0640ea719f2022-12-22T00:15:10ZengWolters Kluwer Medknow PublicationsJournal of Indian Association of Pediatric Surgeons0971-92611998-38912008-01-011325760Embryogenesis of bladder exstrophy: A new hypothesisKulkarni BharatiChaudhari Navin<b>Aims and Objective:</b> To postulate a hypothesis to explain the embryogenesis of exstrophy bladder based on our clinical observations. <b> Materials and Methods:</b> In 27 cases of exstrophy, we measured the distance between the lowermost inguinal skin crease to the root of the penis (clitoris) (B) and the distance between the penis (clitoris) and the scrotum (labia majora) (C). These were compared with age, height and XP distance (distance between xiphisternum and symphysis pubis) matched control group of normal children. The distance between the lowermost inguinal skin crease and the penis (clitoris) (A) was measured in control group. <b> Results:</b> The observation was A = B + C. This implies that in exstrophy bladder, the position of the penis (clitoris) has moved cephalad from the lower border of A to the junction of B and C. <b> Conclusion:</b> Based on the observations, we postulate that abnormal origin of genital tubercle may be the cause of exstrophy bladder. The abnormal origin of primordia of the genital tubercle in more cephalad direction than normal causes wedge effect, which will interfere with the medial migration of the mesoderm as well as the midline approximation of mesodermal structures in the lower abdominal wall, thereby resulting in the exstrophy of bladder.http://www.jiaps.com/article.asp?issn=0971-9261;year=2008;volume=13;issue=2;spage=57;epage=60;aulast=KulkarniBladder exstrophyembryology of cloacagenital tubercle |
| spellingShingle | Kulkarni Bharati Chaudhari Navin Embryogenesis of bladder exstrophy: A new hypothesis Journal of Indian Association of Pediatric Surgeons Bladder exstrophy embryology of cloaca genital tubercle |
| title | Embryogenesis of bladder exstrophy: A new hypothesis |
| title_full | Embryogenesis of bladder exstrophy: A new hypothesis |
| title_fullStr | Embryogenesis of bladder exstrophy: A new hypothesis |
| title_full_unstemmed | Embryogenesis of bladder exstrophy: A new hypothesis |
| title_short | Embryogenesis of bladder exstrophy: A new hypothesis |
| title_sort | embryogenesis of bladder exstrophy a new hypothesis |
| topic | Bladder exstrophy embryology of cloaca genital tubercle |
| url | http://www.jiaps.com/article.asp?issn=0971-9261;year=2008;volume=13;issue=2;spage=57;epage=60;aulast=Kulkarni |
| work_keys_str_mv | AT kulkarnibharati embryogenesisofbladderexstrophyanewhypothesis AT chaudharinavin embryogenesisofbladderexstrophyanewhypothesis |