A dual osteoconductive-osteoprotective implantable device for vertical alveolar ridge augmentation
Repair of large oral bone defects such as vertical alveolar ridge augmentation could benefit from the rapidly developing additive manufacturing technology used to create personalized osteoconductive devices made from porous tricalcium phosphate/hydroxyapatite (TCP/HA)-based bioceramics. These device...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-01-01
|
| Series: | Frontiers in Dental Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fdmed.2022.1066501/full |
| _version_ | 1797961884607971328 |
|---|---|
| author | Jacob Dairaghi Claudia Benito Alston Rachel Cadle Dan Rogozea Luis Solorio Clark T. Barco Nicanor I. Moldovan Nicanor I. Moldovan |
| author_facet | Jacob Dairaghi Claudia Benito Alston Rachel Cadle Dan Rogozea Luis Solorio Clark T. Barco Nicanor I. Moldovan Nicanor I. Moldovan |
| author_sort | Jacob Dairaghi |
| collection | DOAJ |
| description | Repair of large oral bone defects such as vertical alveolar ridge augmentation could benefit from the rapidly developing additive manufacturing technology used to create personalized osteoconductive devices made from porous tricalcium phosphate/hydroxyapatite (TCP/HA)-based bioceramics. These devices can be also used as hydrogel carriers to improve their osteogenic potential. However, the TCP/HA constructs are prone to brittle fracture, therefore their use in clinical situations is difficult. As a solution, we propose the protection of this osteoconductive multi-material (herein called “core”) with a shape-matched “cover” made from biocompatible poly-ɛ-caprolactone (PCL), which is a ductile, and thus more resistant polymeric material. In this report, we present a workflow starting from patient-specific medical scan in Digital Imaging and Communications in Medicine (DICOM) format files, up to the design and 3D printing of a hydrogel-loaded porous TCP/HA core and of its corresponding PCL cover. This cover could also facilitate the anchoring of the device to the patient's defect site via fixing screws. The large, linearly aligned pores in the TCP/HA bioceramic core, their sizes, and their filling with an alginate hydrogel were analyzed by micro-CT. Moreover, we created a finite element analysis (FEA) model of this dual-function device, which permits the simulation of its mechanical behavior in various anticipated clinical situations, as well as optimization before surgery. In conclusion, we designed and 3D-printed a novel, structurally complex multi-material osteoconductive-osteoprotective device with anticipated mechanical properties suitable for large-defect oral bone regeneration. |
| first_indexed | 2024-04-11T01:04:48Z |
| format | Article |
| id | doaj.art-edd8845ceb494b9e8f99981367d43bfa |
| institution | Directory Open Access Journal |
| issn | 2673-4915 |
| language | English |
| last_indexed | 2024-04-11T01:04:48Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Dental Medicine |
| spelling | doaj.art-edd8845ceb494b9e8f99981367d43bfa2023-01-04T13:46:16ZengFrontiers Media S.A.Frontiers in Dental Medicine2673-49152023-01-01310.3389/fdmed.2022.10665011066501A dual osteoconductive-osteoprotective implantable device for vertical alveolar ridge augmentationJacob Dairaghi0Claudia Benito Alston1Rachel Cadle2Dan Rogozea3Luis Solorio4Clark T. Barco5Nicanor I. Moldovan6Nicanor I. Moldovan7Department of Biomedical Engineering, IUPUI, Indianapolis, IN, United StatesWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United StatesDepartment of Biomedical Engineering, IUPUI, Indianapolis, IN, United StatesDepartment of Biomedical Engineering, IUPUI, Indianapolis, IN, United StatesWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United StatesDepartment of Dentistry, Richard L. Roudebush VA Medical Center, Indianapolis, IN, United StatesDepartment of Dentistry, Richard L. Roudebush VA Medical Center, Indianapolis, IN, United States3D Tissue Bioprinting Core Laboratory, Indiana Institute for Medical Research, Indianapolis, IN, United StatesRepair of large oral bone defects such as vertical alveolar ridge augmentation could benefit from the rapidly developing additive manufacturing technology used to create personalized osteoconductive devices made from porous tricalcium phosphate/hydroxyapatite (TCP/HA)-based bioceramics. These devices can be also used as hydrogel carriers to improve their osteogenic potential. However, the TCP/HA constructs are prone to brittle fracture, therefore their use in clinical situations is difficult. As a solution, we propose the protection of this osteoconductive multi-material (herein called “core”) with a shape-matched “cover” made from biocompatible poly-ɛ-caprolactone (PCL), which is a ductile, and thus more resistant polymeric material. In this report, we present a workflow starting from patient-specific medical scan in Digital Imaging and Communications in Medicine (DICOM) format files, up to the design and 3D printing of a hydrogel-loaded porous TCP/HA core and of its corresponding PCL cover. This cover could also facilitate the anchoring of the device to the patient's defect site via fixing screws. The large, linearly aligned pores in the TCP/HA bioceramic core, their sizes, and their filling with an alginate hydrogel were analyzed by micro-CT. Moreover, we created a finite element analysis (FEA) model of this dual-function device, which permits the simulation of its mechanical behavior in various anticipated clinical situations, as well as optimization before surgery. In conclusion, we designed and 3D-printed a novel, structurally complex multi-material osteoconductive-osteoprotective device with anticipated mechanical properties suitable for large-defect oral bone regeneration.https://www.frontiersin.org/articles/10.3389/fdmed.2022.1066501/full3D printingbioprintingdigital designmandibularosteoconductiveosteoprotective |
| spellingShingle | Jacob Dairaghi Claudia Benito Alston Rachel Cadle Dan Rogozea Luis Solorio Clark T. Barco Nicanor I. Moldovan Nicanor I. Moldovan A dual osteoconductive-osteoprotective implantable device for vertical alveolar ridge augmentation Frontiers in Dental Medicine 3D printing bioprinting digital design mandibular osteoconductive osteoprotective |
| title | A dual osteoconductive-osteoprotective implantable device for vertical alveolar ridge augmentation |
| title_full | A dual osteoconductive-osteoprotective implantable device for vertical alveolar ridge augmentation |
| title_fullStr | A dual osteoconductive-osteoprotective implantable device for vertical alveolar ridge augmentation |
| title_full_unstemmed | A dual osteoconductive-osteoprotective implantable device for vertical alveolar ridge augmentation |
| title_short | A dual osteoconductive-osteoprotective implantable device for vertical alveolar ridge augmentation |
| title_sort | dual osteoconductive osteoprotective implantable device for vertical alveolar ridge augmentation |
| topic | 3D printing bioprinting digital design mandibular osteoconductive osteoprotective |
| url | https://www.frontiersin.org/articles/10.3389/fdmed.2022.1066501/full |
| work_keys_str_mv | AT jacobdairaghi adualosteoconductiveosteoprotectiveimplantabledeviceforverticalalveolarridgeaugmentation AT claudiabenitoalston adualosteoconductiveosteoprotectiveimplantabledeviceforverticalalveolarridgeaugmentation AT rachelcadle adualosteoconductiveosteoprotectiveimplantabledeviceforverticalalveolarridgeaugmentation AT danrogozea adualosteoconductiveosteoprotectiveimplantabledeviceforverticalalveolarridgeaugmentation AT luissolorio adualosteoconductiveosteoprotectiveimplantabledeviceforverticalalveolarridgeaugmentation AT clarktbarco adualosteoconductiveosteoprotectiveimplantabledeviceforverticalalveolarridgeaugmentation AT nicanorimoldovan adualosteoconductiveosteoprotectiveimplantabledeviceforverticalalveolarridgeaugmentation AT nicanorimoldovan adualosteoconductiveosteoprotectiveimplantabledeviceforverticalalveolarridgeaugmentation AT jacobdairaghi dualosteoconductiveosteoprotectiveimplantabledeviceforverticalalveolarridgeaugmentation AT claudiabenitoalston dualosteoconductiveosteoprotectiveimplantabledeviceforverticalalveolarridgeaugmentation AT rachelcadle dualosteoconductiveosteoprotectiveimplantabledeviceforverticalalveolarridgeaugmentation AT danrogozea dualosteoconductiveosteoprotectiveimplantabledeviceforverticalalveolarridgeaugmentation AT luissolorio dualosteoconductiveosteoprotectiveimplantabledeviceforverticalalveolarridgeaugmentation AT clarktbarco dualosteoconductiveosteoprotectiveimplantabledeviceforverticalalveolarridgeaugmentation AT nicanorimoldovan dualosteoconductiveosteoprotectiveimplantabledeviceforverticalalveolarridgeaugmentation AT nicanorimoldovan dualosteoconductiveosteoprotectiveimplantabledeviceforverticalalveolarridgeaugmentation |