Does Schizophrenia Itself Cause Obesity?
BackgroundSchizophrenia (SC) is considered the most serious of all mental disorders. Some antipsychotics are associated with weight gain and metabolic abnormalities. Whether SC itself causes obesity remains uncertain.MethodsWe collected 185 first-episode drug-naive SC and 59 healthy controls (HCs) f...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.934384/full |
| _version_ | 1811241491887030272 |
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| author | Jiaquan Liang Yanshan Cai Xiongyan Xue Xiaoling Li Zaifang Li Caixia Xu Guojun Xie Yang Yu |
| author_facet | Jiaquan Liang Yanshan Cai Xiongyan Xue Xiaoling Li Zaifang Li Caixia Xu Guojun Xie Yang Yu |
| author_sort | Jiaquan Liang |
| collection | DOAJ |
| description | BackgroundSchizophrenia (SC) is considered the most serious of all mental disorders. Some antipsychotics are associated with weight gain and metabolic abnormalities. Whether SC itself causes obesity remains uncertain.MethodsWe collected 185 first-episode drug-naive SC and 59 healthy controls (HCs) from the Third People’s Hospital of Foshan, Guangdong, China, and distinguished their course of disease in order to understand the body mass index (BMI) and body fat metabolism of SC.ResultsWe found that excluding the drug factors, the longer the course of SC, the more obvious the increase of BMI and the higher the proportion of obesity. BMI was positively correlated with age, course of disease, fasting blood glucose (FBG), low-density lipoprotein (LDL), triglyceride (TG), and total cholesterol (TC), and negatively correlated with high-density lipoprotein (HDL). The results of regression analysis were further proof that age (B = 0.094, p < 0.001), duration (B = 0.081, p = 0.002), FBG (B = 0.987, p = 0.004), and TG (B = 0.918, p = 0.002) were the risk factors for the increase of BMI. HDL (B = –2.875, p < 0.001) was the protective factor.ConclusionSC itself can increase BMI and easily lead to obesity. We should pay more attention to the monitoring of blood metabolism indicators, so as to reduce the risk of obesity and improve the quality of life of patients. |
| first_indexed | 2024-04-12T13:36:58Z |
| format | Article |
| id | doaj.art-edda052f79f84200a1f26b222f1d7f86 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-12T13:36:58Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-edda052f79f84200a1f26b222f1d7f862022-12-22T03:30:59ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402022-06-011310.3389/fpsyt.2022.934384934384Does Schizophrenia Itself Cause Obesity?Jiaquan LiangYanshan CaiXiongyan XueXiaoling LiZaifang LiCaixia XuGuojun XieYang YuBackgroundSchizophrenia (SC) is considered the most serious of all mental disorders. Some antipsychotics are associated with weight gain and metabolic abnormalities. Whether SC itself causes obesity remains uncertain.MethodsWe collected 185 first-episode drug-naive SC and 59 healthy controls (HCs) from the Third People’s Hospital of Foshan, Guangdong, China, and distinguished their course of disease in order to understand the body mass index (BMI) and body fat metabolism of SC.ResultsWe found that excluding the drug factors, the longer the course of SC, the more obvious the increase of BMI and the higher the proportion of obesity. BMI was positively correlated with age, course of disease, fasting blood glucose (FBG), low-density lipoprotein (LDL), triglyceride (TG), and total cholesterol (TC), and negatively correlated with high-density lipoprotein (HDL). The results of regression analysis were further proof that age (B = 0.094, p < 0.001), duration (B = 0.081, p = 0.002), FBG (B = 0.987, p = 0.004), and TG (B = 0.918, p = 0.002) were the risk factors for the increase of BMI. HDL (B = –2.875, p < 0.001) was the protective factor.ConclusionSC itself can increase BMI and easily lead to obesity. We should pay more attention to the monitoring of blood metabolism indicators, so as to reduce the risk of obesity and improve the quality of life of patients.https://www.frontiersin.org/articles/10.3389/fpsyt.2022.934384/fullmetabolic indexesobesityoverweightbody mass indexschizophrenia |
| spellingShingle | Jiaquan Liang Yanshan Cai Xiongyan Xue Xiaoling Li Zaifang Li Caixia Xu Guojun Xie Yang Yu Does Schizophrenia Itself Cause Obesity? Frontiers in Psychiatry metabolic indexes obesity overweight body mass index schizophrenia |
| title | Does Schizophrenia Itself Cause Obesity? |
| title_full | Does Schizophrenia Itself Cause Obesity? |
| title_fullStr | Does Schizophrenia Itself Cause Obesity? |
| title_full_unstemmed | Does Schizophrenia Itself Cause Obesity? |
| title_short | Does Schizophrenia Itself Cause Obesity? |
| title_sort | does schizophrenia itself cause obesity |
| topic | metabolic indexes obesity overweight body mass index schizophrenia |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.934384/full |
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