PE_PGRS31-S100A9 Interaction Promotes Mycobacterial Survival in Macrophages Through the Regulation of NF-κB-TNF-α Signaling and Arachidonic Acid Metabolism

PE_PGRS31-S100A9 Interaction Promotes Mycobacterial Survival in Macrophages Through the Regulation of NF-κB-TNF-α Signaling and Arachidonic Acid Metabolism

Mycobacterium tuberculosis (M. tb) evades the surveillance of immune responses for survival in macrophages. However, the precise mechanism and toxins/proteins encoded by M. tb involved in the bacterial escape remain elusive. The function of Rv1768 protein (also referred to as PE_PGRS31, belonging to...

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Bibliographic Details
Main Authors: Sheng Liu, Yan Xie, Wei Luo, Yafeng Dou, Huan Xiong, Zhen Xiao, Xiao-Lian Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Microbiology
Subjects:
Mycobacterium tuberculosis
Rv1768/PE_PGRS31
S100A9
tumor necrosis factor α (TNF-α)
region of deletion (RD) 14
macrophage
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.00845/full

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