GASOTRANSMITTERS: FROM THE TOXIC EFFECTS TO THE REGULATION OF CELLULAR FUNCTION AND CLINICAL APPLICATION

Nitric oxide II (NO), carbon monoxide (СО) and hydrogen sulfide (H2S) for many decades were described as the toxic gases inducing damaging action in man’s organisms. Recently it was found that NO, CO and H2S endogenously synthesized and served as signaling molecules of autocrine and paracrine regula...

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Main Authors: G. F. Sitdikova, A. V. Yakovlev, A. L. Zefirov
Format: Article
Language:English
Published: Siberian State Medical University (Tomsk) 2014-12-01
Series:Бюллетень сибирской медицины
Subjects:
Online Access:https://bulletin.ssmu.ru/jour/article/view/178
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author G. F. Sitdikova
A. V. Yakovlev
A. L. Zefirov
author_facet G. F. Sitdikova
A. V. Yakovlev
A. L. Zefirov
author_sort G. F. Sitdikova
collection DOAJ
description Nitric oxide II (NO), carbon monoxide (СО) and hydrogen sulfide (H2S) for many decades were described as the toxic gases inducing damaging action in man’s organisms. Recently it was found that NO, CO and H2S endogenously synthesized and served as signaling molecules of autocrine and paracrine regulation in many systems. The properties, mechanisms of synthesis and action in excitable systems are presented in this paper. Besides we also descried our results concerning the effects and mechanisms of action of gaseous messengers in peripheral nervous system – in neuromuscular junction.
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spelling doaj.art-eddaea1762c44a4786692df6ae6d1d762023-03-13T09:58:20ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842014-12-0113618520010.20538/1682-0363-2014-6-185-200176GASOTRANSMITTERS: FROM THE TOXIC EFFECTS TO THE REGULATION OF CELLULAR FUNCTION AND CLINICAL APPLICATIONG. F. Sitdikova0A. V. Yakovlev1A. L. Zefirov2Казанский (Приволжский) федеральный университет, Институт фундаментальной медицины и биологии; Казань Казанский государственный медицинский университет, КазаньКазанский (Приволжский) федеральный университет, Институт фундаментальной медицины и биологии; Казань Казанский государственный медицинский университет, КазаньКазанский (Приволжский) федеральный университет, Институт фундаментальной медицины и биологии; Казань Казанский государственный медицинский университет, КазаньNitric oxide II (NO), carbon monoxide (СО) and hydrogen sulfide (H2S) for many decades were described as the toxic gases inducing damaging action in man’s organisms. Recently it was found that NO, CO and H2S endogenously synthesized and served as signaling molecules of autocrine and paracrine regulation in many systems. The properties, mechanisms of synthesis and action in excitable systems are presented in this paper. Besides we also descried our results concerning the effects and mechanisms of action of gaseous messengers in peripheral nervous system – in neuromuscular junction.https://bulletin.ssmu.ru/jour/article/view/178рнф
spellingShingle G. F. Sitdikova
A. V. Yakovlev
A. L. Zefirov
GASOTRANSMITTERS: FROM THE TOXIC EFFECTS TO THE REGULATION OF CELLULAR FUNCTION AND CLINICAL APPLICATION
Бюллетень сибирской медицины
рнф
title GASOTRANSMITTERS: FROM THE TOXIC EFFECTS TO THE REGULATION OF CELLULAR FUNCTION AND CLINICAL APPLICATION
title_full GASOTRANSMITTERS: FROM THE TOXIC EFFECTS TO THE REGULATION OF CELLULAR FUNCTION AND CLINICAL APPLICATION
title_fullStr GASOTRANSMITTERS: FROM THE TOXIC EFFECTS TO THE REGULATION OF CELLULAR FUNCTION AND CLINICAL APPLICATION
title_full_unstemmed GASOTRANSMITTERS: FROM THE TOXIC EFFECTS TO THE REGULATION OF CELLULAR FUNCTION AND CLINICAL APPLICATION
title_short GASOTRANSMITTERS: FROM THE TOXIC EFFECTS TO THE REGULATION OF CELLULAR FUNCTION AND CLINICAL APPLICATION
title_sort gasotransmitters from the toxic effects to the regulation of cellular function and clinical application
topic рнф
url https://bulletin.ssmu.ru/jour/article/view/178
work_keys_str_mv AT gfsitdikova gasotransmittersfromthetoxiceffectstotheregulationofcellularfunctionandclinicalapplication
AT avyakovlev gasotransmittersfromthetoxiceffectstotheregulationofcellularfunctionandclinicalapplication
AT alzefirov gasotransmittersfromthetoxiceffectstotheregulationofcellularfunctionandclinicalapplication