Peripheral Nerve Regeneration at 1 Year: Biodegradable Polybutylene Succinate Artificial Scaffold vs. Conventional Epineurial Sutures
The utilization of a planar poly(1,4-butylene succinate) (PBS) scaffold has been demonstrated as an effective approach for preserving nerve continuity and facilitating nerve regeneration. In this study, we assessed the characteristics of a microfibrous tubular scaffold specifically designed and fabr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/15/16/3398 |
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| author | Luca Cicero Roberto Puleio Giovanni Cassata Roberta Cirincione Lawrence Camarda Dario Caracappa Lorenzo D’Itri Mariano Licciardi Giulio Edoardo Vigni |
| author_facet | Luca Cicero Roberto Puleio Giovanni Cassata Roberta Cirincione Lawrence Camarda Dario Caracappa Lorenzo D’Itri Mariano Licciardi Giulio Edoardo Vigni |
| author_sort | Luca Cicero |
| collection | DOAJ |
| description | The utilization of a planar poly(1,4-butylene succinate) (PBS) scaffold has been demonstrated as an effective approach for preserving nerve continuity and facilitating nerve regeneration. In this study, we assessed the characteristics of a microfibrous tubular scaffold specifically designed and fabricated through electrospinning, utilizing PBS as a biocompatible and biodegradable material. These scaffolds were evaluated as nerve guide conduits in a rat model of sciatic nerve neurotmesis, demonstrating both their biodegradability and efficacy in enhancing the reconstruction process over a long-term period (1-year follow-up). Histological assay and electrophysiological evaluation were performed to compare the long-term outcomes following sutureless repair with the microfibrillar wrap to outcomes obtained using traditional suture repair. |
| first_indexed | 2024-03-10T23:38:07Z |
| format | Article |
| id | doaj.art-eddc77d5e7334b63ba5c92b05d522cf1 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T23:38:07Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-eddc77d5e7334b63ba5c92b05d522cf12023-11-19T02:43:40ZengMDPI AGPolymers2073-43602023-08-011516339810.3390/polym15163398Peripheral Nerve Regeneration at 1 Year: Biodegradable Polybutylene Succinate Artificial Scaffold vs. Conventional Epineurial SuturesLuca Cicero0Roberto Puleio1Giovanni Cassata2Roberta Cirincione3Lawrence Camarda4Dario Caracappa5Lorenzo D’Itri6Mariano Licciardi7Giulio Edoardo Vigni8Centro Mediterraneo Ricerca e Training (Ce.Me.Ri.T), Istituto Zooprofilattico Sperimentale della Sicilia “A. Mirri”, 90129 Palermo, ItalyLaboratorio Istopatologia e Immunoistochimica, Dipartimento Ricerca Biotecnologica e Diagnostica Specialistica, Istituto Zooprofilattico Sperimentale della Sicilia “A. Mirri”, 90129 Palermo, ItalyCentro Mediterraneo Ricerca e Training (Ce.Me.Ri.T), Istituto Zooprofilattico Sperimentale della Sicilia “A. Mirri”, 90129 Palermo, ItalyCentro Mediterraneo Ricerca e Training (Ce.Me.Ri.T), Istituto Zooprofilattico Sperimentale della Sicilia “A. Mirri”, 90129 Palermo, ItalyDepartment of Orthopaedics and Traumatology, University of Palermo, 90133 Palermo, ItalyDipartimento di Discipline Chirurgiche, Oncologiche e Stomatologiche (DICHIRONS), Università degli Studi di Palermo, 90127 Palermo, ItalyDepartment of Orthopaedics and Traumatology, University of Palermo, 90133 Palermo, ItalyDipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Università degli Studi di Palermo, 90132 Palermo, ItalyDepartment of Orthopaedics and Traumatology, University of Palermo, 90133 Palermo, ItalyThe utilization of a planar poly(1,4-butylene succinate) (PBS) scaffold has been demonstrated as an effective approach for preserving nerve continuity and facilitating nerve regeneration. In this study, we assessed the characteristics of a microfibrous tubular scaffold specifically designed and fabricated through electrospinning, utilizing PBS as a biocompatible and biodegradable material. These scaffolds were evaluated as nerve guide conduits in a rat model of sciatic nerve neurotmesis, demonstrating both their biodegradability and efficacy in enhancing the reconstruction process over a long-term period (1-year follow-up). Histological assay and electrophysiological evaluation were performed to compare the long-term outcomes following sutureless repair with the microfibrillar wrap to outcomes obtained using traditional suture repair.https://www.mdpi.com/2073-4360/15/16/3398poly(1,4-butylene succinate)nerve regenerationelectrospinning |
| spellingShingle | Luca Cicero Roberto Puleio Giovanni Cassata Roberta Cirincione Lawrence Camarda Dario Caracappa Lorenzo D’Itri Mariano Licciardi Giulio Edoardo Vigni Peripheral Nerve Regeneration at 1 Year: Biodegradable Polybutylene Succinate Artificial Scaffold vs. Conventional Epineurial Sutures Polymers poly(1,4-butylene succinate) nerve regeneration electrospinning |
| title | Peripheral Nerve Regeneration at 1 Year: Biodegradable Polybutylene Succinate Artificial Scaffold vs. Conventional Epineurial Sutures |
| title_full | Peripheral Nerve Regeneration at 1 Year: Biodegradable Polybutylene Succinate Artificial Scaffold vs. Conventional Epineurial Sutures |
| title_fullStr | Peripheral Nerve Regeneration at 1 Year: Biodegradable Polybutylene Succinate Artificial Scaffold vs. Conventional Epineurial Sutures |
| title_full_unstemmed | Peripheral Nerve Regeneration at 1 Year: Biodegradable Polybutylene Succinate Artificial Scaffold vs. Conventional Epineurial Sutures |
| title_short | Peripheral Nerve Regeneration at 1 Year: Biodegradable Polybutylene Succinate Artificial Scaffold vs. Conventional Epineurial Sutures |
| title_sort | peripheral nerve regeneration at 1 year biodegradable polybutylene succinate artificial scaffold vs conventional epineurial sutures |
| topic | poly(1,4-butylene succinate) nerve regeneration electrospinning |
| url | https://www.mdpi.com/2073-4360/15/16/3398 |
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