Investigation of market herbal products regulated under different categories: How can HPTLC help to detect quality problems?
Background: Herbal products regulated under different categories were found to be of different quality. This has been demonstrated by the increasing number of reports on the quality of herbal products in the scientific literature. Proper identification is an effective way to address this concerning...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.925298/full |
| _version_ | 1818490266225475584 |
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| author | Débora A. Frommenwiler Débora A. Frommenwiler Eike Reich Maged H. M. Sharaf Salvador Cañigueral Christopher J. Etheridge |
| author_facet | Débora A. Frommenwiler Débora A. Frommenwiler Eike Reich Maged H. M. Sharaf Salvador Cañigueral Christopher J. Etheridge |
| author_sort | Débora A. Frommenwiler |
| collection | DOAJ |
| description | Background: Herbal products regulated under different categories were found to be of different quality. This has been demonstrated by the increasing number of reports on the quality of herbal products in the scientific literature. Proper identification is an effective way to address this concerning issue early on in a products’ manufacturing process.Objectives: To assess the quality of milk thistle, coneflower and black cohosh herbal drugs, preparations and products commercialized under different regulatory categories, and to illustrate the usefulness of HPTLC as a tool for evaluating quality.Methods: HPTLC methods were adapted from the European Pharmacopeia’s monographs for milk thistle fruits, black cohosh and purple coneflower. Additional detection modes beyond those described in the monographs were employed, and the entire HPTLC fingerprints were used for examination of identity and purity of the investigated samples.Results: All products regulated as Traditional Herbal Medicinal Products were shown to be of high quality: their fingerprints were consistent and without unexpected zones. A significant number of food supplements show quality issues (mainly adulterations): 52.4% of milk thistle, 33.3% of coneflower, and 45.5% of black cohosh products. The same was observed in 66.6% of black cohosh herbal drugs and preparations. |
| first_indexed | 2024-12-10T17:14:25Z |
| format | Article |
| id | doaj.art-eddceeb63328449cbd964960204aff1c |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-10T17:14:25Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-eddceeb63328449cbd964960204aff1c2022-12-22T01:40:11ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-08-011310.3389/fphar.2022.925298925298Investigation of market herbal products regulated under different categories: How can HPTLC help to detect quality problems?Débora A. Frommenwiler0Débora A. Frommenwiler1Eike Reich2Maged H. M. Sharaf3Salvador Cañigueral4Christopher J. Etheridge5CAMAG Laboratory, Muttenz, SwitzerlandUnit of Pharmacology, Pharmacognosy and Therapeutics, Faculty of Pharmacy and Food Sciences, Universitat de Barcelona, Barcelona, SpainCAMAG Laboratory, Muttenz, SwitzerlandHPTLC Association, Rheinfelden, SwitzerlandUnit of Pharmacology, Pharmacognosy and Therapeutics, Faculty of Pharmacy and Food Sciences, Universitat de Barcelona, Barcelona, SpainBritish Herbal Medicine Association (BHMA), Exeter, United KingdomBackground: Herbal products regulated under different categories were found to be of different quality. This has been demonstrated by the increasing number of reports on the quality of herbal products in the scientific literature. Proper identification is an effective way to address this concerning issue early on in a products’ manufacturing process.Objectives: To assess the quality of milk thistle, coneflower and black cohosh herbal drugs, preparations and products commercialized under different regulatory categories, and to illustrate the usefulness of HPTLC as a tool for evaluating quality.Methods: HPTLC methods were adapted from the European Pharmacopeia’s monographs for milk thistle fruits, black cohosh and purple coneflower. Additional detection modes beyond those described in the monographs were employed, and the entire HPTLC fingerprints were used for examination of identity and purity of the investigated samples.Results: All products regulated as Traditional Herbal Medicinal Products were shown to be of high quality: their fingerprints were consistent and without unexpected zones. A significant number of food supplements show quality issues (mainly adulterations): 52.4% of milk thistle, 33.3% of coneflower, and 45.5% of black cohosh products. The same was observed in 66.6% of black cohosh herbal drugs and preparations.https://www.frontiersin.org/articles/10.3389/fphar.2022.925298/fullHPTLCconeflowermilk thistle (Silybum marianum)black cohoshfood supplementTHMP |
| spellingShingle | Débora A. Frommenwiler Débora A. Frommenwiler Eike Reich Maged H. M. Sharaf Salvador Cañigueral Christopher J. Etheridge Investigation of market herbal products regulated under different categories: How can HPTLC help to detect quality problems? Frontiers in Pharmacology HPTLC coneflower milk thistle (Silybum marianum) black cohosh food supplement THMP |
| title | Investigation of market herbal products regulated under different categories: How can HPTLC help to detect quality problems? |
| title_full | Investigation of market herbal products regulated under different categories: How can HPTLC help to detect quality problems? |
| title_fullStr | Investigation of market herbal products regulated under different categories: How can HPTLC help to detect quality problems? |
| title_full_unstemmed | Investigation of market herbal products regulated under different categories: How can HPTLC help to detect quality problems? |
| title_short | Investigation of market herbal products regulated under different categories: How can HPTLC help to detect quality problems? |
| title_sort | investigation of market herbal products regulated under different categories how can hptlc help to detect quality problems |
| topic | HPTLC coneflower milk thistle (Silybum marianum) black cohosh food supplement THMP |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.925298/full |
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