Mechanisms of castration resistant prostate cancer formation and progression through neuroendocrine differentiation
Normal prostate tissues consist mainly of epithelial cells, including secretory epithelial cells, basal cells, and neuroendocrine cells, and of mesenchymal cells, including smooth muscle cells and fibroblasts. The mechanisms leading to castration resistant prostate cancer (CRPC) are complex and d...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MRE Press
2021-09-01
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| Series: | Journal of Men's Health |
| Subjects: | |
| Online Access: | https://oss.jomh.org/jomh/article/20210928-441/pdf/JOMH2021030202.pdf |
| Summary: | Normal prostate tissues consist mainly of epithelial cells, including secretory
epithelial cells, basal cells, and neuroendocrine cells, and of mesenchymal
cells, including smooth muscle cells and fibroblasts. The mechanisms leading to
castration resistant prostate cancer (CRPC) are complex and diverse, but most
involve neuroendocrine differentiation. In fact, during the development of
prostate cancer, some of the tumor cells transform into neuroendocrine-like
cells. This transition is a main underlying mechanism of CRPC formation. |
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| ISSN: | 1875-6859 |