The establishment of COPD organoids to study host-pathogen interaction reveals enhanced viral fitness of SARS-CoV-2 in bronchi
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory respiratory disease characterized by airflow limitation and infective exacerbations. Here, Chan et al. report the generation of nasopharyngeal and bronchial COPD organoids derived from adult stem cells and employ them in the stud...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-35253-x |
| _version_ | 1811188243549388800 |
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| author | Louisa L. Y. Chan Danielle E. Anderson Hong Sheng Cheng Fransiskus Xaverius Ivan Si Chen Adrian E. Z. Kang Randy Foo Akshamal M. Gamage Pei Yee Tiew Mariko Siyue Koh Ken Cheah Hooi Lee Kristy Nichol Prabuddha S. Pathinayake Yik Lung Chan Tsin Wen Yeo Brian G. Oliver Peter A. B. Wark Linbo Liu Nguan Soon Tan Lin-Fa Wang Sanjay H. Chotirmall |
| author_facet | Louisa L. Y. Chan Danielle E. Anderson Hong Sheng Cheng Fransiskus Xaverius Ivan Si Chen Adrian E. Z. Kang Randy Foo Akshamal M. Gamage Pei Yee Tiew Mariko Siyue Koh Ken Cheah Hooi Lee Kristy Nichol Prabuddha S. Pathinayake Yik Lung Chan Tsin Wen Yeo Brian G. Oliver Peter A. B. Wark Linbo Liu Nguan Soon Tan Lin-Fa Wang Sanjay H. Chotirmall |
| author_sort | Louisa L. Y. Chan |
| collection | DOAJ |
| description | Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory respiratory disease characterized by airflow limitation and infective exacerbations. Here, Chan et al. report the generation of nasopharyngeal and bronchial COPD organoids derived from adult stem cells and employ them in the study of host-pathogen interactions, including SARS-CoV-2 and Pseudomonas aeruginosa. |
| first_indexed | 2024-04-11T14:16:16Z |
| format | Article |
| id | doaj.art-ede2ba3eb3ee4bc2bdcf003223f85869 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T14:16:16Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ede2ba3eb3ee4bc2bdcf003223f858692022-12-22T04:19:25ZengNature PortfolioNature Communications2041-17232022-12-0113111810.1038/s41467-022-35253-xThe establishment of COPD organoids to study host-pathogen interaction reveals enhanced viral fitness of SARS-CoV-2 in bronchiLouisa L. Y. Chan0Danielle E. Anderson1Hong Sheng Cheng2Fransiskus Xaverius Ivan3Si Chen4Adrian E. Z. Kang5Randy Foo6Akshamal M. Gamage7Pei Yee Tiew8Mariko Siyue Koh9Ken Cheah Hooi Lee10Kristy Nichol11Prabuddha S. Pathinayake12Yik Lung Chan13Tsin Wen Yeo14Brian G. Oliver15Peter A. B. Wark16Linbo Liu17Nguan Soon Tan18Lin-Fa Wang19Sanjay H. Chotirmall20Lee Kong Chian School of Medicine, Nanyang Technological UniversityProgramme in Emerging Infectious Diseases, Duke-NUS Medical SchoolLee Kong Chian School of Medicine, Nanyang Technological UniversityLee Kong Chian School of Medicine, Nanyang Technological UniversitySchool of Electrical and Electronic Engineering, Nanyang Technological UniversityProgramme in Emerging Infectious Diseases, Duke-NUS Medical SchoolProgramme in Emerging Infectious Diseases, Duke-NUS Medical SchoolProgramme in Emerging Infectious Diseases, Duke-NUS Medical SchoolLee Kong Chian School of Medicine, Nanyang Technological UniversityDepartment of Respiratory and Critical Care Medicine, Singapore General HospitalDepartment of Respiratory and Critical Care Medicine, Singapore General HospitalPriority Research Centre for Healthy Lungs, Hunter Medical Research Institute and School of Medicine and Public Health, University of NewcastlePriority Research Centre for Healthy Lungs, Hunter Medical Research Institute and School of Medicine and Public Health, University of NewcastleSchool of Life Sciences, Faculty of Science, University of Technology SydneyLee Kong Chian School of Medicine, Nanyang Technological UniversitySchool of Life Sciences, Faculty of Science, University of Technology SydneyPriority Research Centre for Healthy Lungs, Hunter Medical Research Institute and School of Medicine and Public Health, University of NewcastleSchool of Electrical and Electronic Engineering, Nanyang Technological UniversityLee Kong Chian School of Medicine, Nanyang Technological UniversityProgramme in Emerging Infectious Diseases, Duke-NUS Medical SchoolLee Kong Chian School of Medicine, Nanyang Technological UniversityChronic obstructive pulmonary disease (COPD) is a chronic inflammatory respiratory disease characterized by airflow limitation and infective exacerbations. Here, Chan et al. report the generation of nasopharyngeal and bronchial COPD organoids derived from adult stem cells and employ them in the study of host-pathogen interactions, including SARS-CoV-2 and Pseudomonas aeruginosa.https://doi.org/10.1038/s41467-022-35253-x |
| spellingShingle | Louisa L. Y. Chan Danielle E. Anderson Hong Sheng Cheng Fransiskus Xaverius Ivan Si Chen Adrian E. Z. Kang Randy Foo Akshamal M. Gamage Pei Yee Tiew Mariko Siyue Koh Ken Cheah Hooi Lee Kristy Nichol Prabuddha S. Pathinayake Yik Lung Chan Tsin Wen Yeo Brian G. Oliver Peter A. B. Wark Linbo Liu Nguan Soon Tan Lin-Fa Wang Sanjay H. Chotirmall The establishment of COPD organoids to study host-pathogen interaction reveals enhanced viral fitness of SARS-CoV-2 in bronchi Nature Communications |
| title | The establishment of COPD organoids to study host-pathogen interaction reveals enhanced viral fitness of SARS-CoV-2 in bronchi |
| title_full | The establishment of COPD organoids to study host-pathogen interaction reveals enhanced viral fitness of SARS-CoV-2 in bronchi |
| title_fullStr | The establishment of COPD organoids to study host-pathogen interaction reveals enhanced viral fitness of SARS-CoV-2 in bronchi |
| title_full_unstemmed | The establishment of COPD organoids to study host-pathogen interaction reveals enhanced viral fitness of SARS-CoV-2 in bronchi |
| title_short | The establishment of COPD organoids to study host-pathogen interaction reveals enhanced viral fitness of SARS-CoV-2 in bronchi |
| title_sort | establishment of copd organoids to study host pathogen interaction reveals enhanced viral fitness of sars cov 2 in bronchi |
| url | https://doi.org/10.1038/s41467-022-35253-x |
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